Gene Review:
MAP2K6 - mitogen-activated protein kinase kinase 6
Homo sapiens
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAPK/ERK kinase 6, MAPKK 6, MAPKK6, ...
- Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. Martindale, J.J., Wall, J.A., Martinez-Longoria, D.M., Aryal, P., Rockman, H.A., Guo, Y., Bolli, R., Glembotski, C.C. J. Biol. Chem. (2005)
- Involvement of the p38 mitogen-activated protein kinase cascade in hepatocellular carcinoma. Iyoda, K., Sasaki, Y., Horimoto, M., Toyama, T., Yakushijin, T., Sakakibara, M., Takehara, T., Fujimoto, J., Hori, M., Wands, J.R., Hayashi, N. Cancer (2003)
- The use of genetic programming in the analysis of quantitative gene expression profiles for identification of nodal status in bladder cancer. Mitra, A.P., Almal, A.A., George, B., Fry, D.W., Lenehan, P.F., Pagliarulo, V., Cote, R.J., Datar, R.H., Worzel, W.P. BMC Cancer (2006)
- Expression and activation of mitogen-activated protein kinase kinases-3 and -6 in rheumatoid arthritis. Chabaud-Riou, M., Firestein, G.S. Am. J. Pathol. (2004)
- Profiling of protein kinases in the neoplastic transformation of human ovarian surface epithelium. Wong, A.S., Kim, S.O., Leung, P.C., Auersperg, N., Pelech, S.L. Gynecol. Oncol. (2001)
- Activation of MKK6, an upstream activator of p38, in Alzheimer's disease. Zhu, X., Rottkamp, C.A., Hartzler, A., Sun, Z., Takeda, A., Boux, H., Shimohama, S., Perry, G., Smith, M.A. J. Neurochem. (2001)
- p38 pathway targets SWI-SNF chromatin-remodeling complex to muscle-specific loci. Simone, C., Forcales, S.V., Hill, D.A., Imbalzano, A.N., Latella, L., Puri, P.L. Nat. Genet. (2004)
- Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope. Perfettini, J.L., Castedo, M., Nardacci, R., Ciccosanti, F., Boya, P., Roumier, T., Larochette, N., Piacentini, M., Kroemer, G. J. Exp. Med. (2005)
- Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells. Hayashi, K., Takahashi, M., Kimura, K., Nishida, W., Saga, H., Sobue, K. J. Cell Biol. (1999)
- Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades. Fan, H., Derynck, R. EMBO J. (1999)
- Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. Goedert, M., Cuenda, A., Craxton, M., Jakes, R., Cohen, P. EMBO J. (1997)
- c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation. Cong, F., Goff, S.P. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Wang, W., Chen, J.X., Liao, R., Deng, Q., Zhou, J.J., Huang, S., Sun, P. Mol. Cell. Biol. (2002)
- Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells. Cuenda, A., Alonso, G., Morrice, N., Jones, M., Meier, R., Cohen, P., Nebreda, A.R. EMBO J. (1996)
- MEK6 regulates human involucrin gene expression via a p38alpha - and p38delta -dependent mechanism. Dashti, S.R., Efimova, T., Eckert, R.L. J. Biol. Chem. (2001)
- Activation of p38 has opposing effects on the proliferation and migration of endothelial cells. McMullen, M.E., Bryant, P.W., Glembotski, C.C., Vincent, P.A., Pumiglia, K.M. J. Biol. Chem. (2005)
- Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. Stein, B., Brady, H., Yang, M.X., Young, D.B., Barbosa, M.S. J. Biol. Chem. (1996)
- The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. Ludwig, S., Hoffmeyer, A., Goebeler, M., Kilian, K., Häfner, H., Neufeld, B., Han, J., Rapp, U.R. J. Biol. Chem. (1998)
- T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A. Matsuda, S., Moriguchi, T., Koyasu, S., Nishida, E. J. Biol. Chem. (1998)
- Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation. Silva, A.M., Whitmore, M., Xu, Z., Jiang, Z., Li, X., Williams, B.R. J. Biol. Chem. (2004)
- Rac1-MKK3-p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells. Han, Q., Leng, J., Bian, D., Mahanivong, C., Carpenter, K.A., Pan, Z.K., Han, J., Huang, S. J. Biol. Chem. (2002)
- Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding. Mita, H., Tsutsui, J., Takekawa, M., Witten, E.A., Saito, H. Mol. Cell. Biol. (2002)
- Differential activation of p38 mitogen-activated protein kinase isoforms depending on signal strength. Alonso, G., Ambrosino, C., Jones, M., Nebreda, A.R. J. Biol. Chem. (2000)
- A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. Takekawa, M., Posas, F., Saito, H. EMBO J. (1997)
- Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). Cuenda, A., Cohen, P., Buée-Scherrer, V., Goedert, M. EMBO J. (1997)
- Cellular stresses and cytokines activate multiple mitogen-activated-protein kinase kinase homologues in PC12 and KB cells. Meier, R., Rouse, J., Cuenda, A., Nebreda, A.R., Cohen, P. Eur. J. Biochem. (1996)
- The p38 and JNK pathways cooperate to trans-activate vitamin D receptor via c-Jun/AP-1 and sensitize human breast cancer cells to vitamin D(3)-induced growth inhibition. Qi, X., Pramanik, R., Wang, J., Schultz, R.M., Maitra, R.K., Han, J., DeLuca, H.F., Chen, G. J. Biol. Chem. (2002)
- Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase. Kaur, R., Liu, X., Gjoerup, O., Zhang, A., Yuan, X., Balk, S.P., Schneider, M.C., Lu, M.L. J. Biol. Chem. (2005)
- A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. Moriguchi, T., Kuroyanagi, N., Yamaguchi, K., Gotoh, Y., Irie, K., Kano, T., Shirakabe, K., Muro, Y., Shibuya, H., Matsumoto, K., Nishida, E., Hagiwara, M. J. Biol. Chem. (1996)
- Identification of genes associated with cisplatin resistance in human oral squamous cell carcinoma cell line. Zhang, P., Zhang, Z., Zhou, X., Qiu, W., Chen, F., Chen, W. BMC Cancer (2006)
- The mitogen-activated protein (MAP) kinase p38 and its upstream activator MAP kinase kinase 6 are involved in the activation of signal transducer and activator of transcription by hyperosmolarity. Bode, J.G., Gatsios, P., Ludwig, S., Rapp, U.R., Häussinger, D., Heinrich, P.C., Graeve, L. J. Biol. Chem. (1999)