- The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinases. Liu, W., Kato, M., Akhand, A.A., Hayakawa, A., Takemura, M., Yoshida, S., Suzuki, H., Nakashima, I. Int. J. Oncol. (1998)