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Chemical Compound Review

AC1NT0KJ     (2S,3R,4S,5R,6S)-6-(5,6- dihydroxy-4-oxo-2...

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Disease relevance of Baicalin


Psychiatry related information on Baicalin


High impact information on Baicalin


Chemical compound and disease context of Baicalin


Biological context of Baicalin


Anatomical context of Baicalin


Associations of Baicalin with other chemical compounds


Gene context of Baicalin


Analytical, diagnostic and therapeutic context of Baicalin

  • Recently, we isolated a major component (6% of the total ethanolic extract) known as baicalin from PC-SPES by high performance liquid chromatography (HPLC) [2].
  • Western blot analysis examined the effect of baicalin on levels of p21(waf1) and p27(kip1) in those cells [2].
  • A total of 37.0 mg of baicalin at 96.5% purity was yielded from 200 mg of the crude baicalin (containing 21.6% baicalin) with 86.0% recovery as determined by HPLC analysis [24].
  • PURPOSE: Kampo medicine Hangeshashin-to (TJ-14) which contains baicalin, a beta-glucuronidase inhibitor, alleviates diarrhea induced by irinotecan (CPT-11) [25].
  • In this study, RT-PCR and Western blot analyses of SP-A were performed to evaluate the biological activity of baicalin, a Chinese medicine prescribed extensively for preventing miscarriage [26].


  1. Inhibition of human T cell leukemia virus by the plant flavonoid baicalin (7-glucuronic acid, 5,6-dihydroxyflavone). Baylor, N.W., Fu, T., Yan, Y.D., Ruscetti, F.W. J. Infect. Dis. (1992) [Pubmed]
  2. Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest. Ikezoe, T., Chen, S.S., Heber, D., Taguchi, H., Koeffler, H.P. Prostate (2001) [Pubmed]
  3. Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Li, B.Q., Fu, T., Dongyan, Y., Mikovits, J.A., Ruscetti, F.W., Wang, J.M. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  4. Effects of dietary baicalin supplementation on iron overload-induced mouse liver oxidative injury. Zhao, Y., Li, H., Gao, Z., Xu, H. Eur. J. Pharmacol. (2005) [Pubmed]
  5. Potent Inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. Heo, H.J., Kim, D.O., Choi, S.J., Shin, D.H., Lee, C.Y. J. Agric. Food Chem. (2004) [Pubmed]
  6. Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Ma, Z., Otsuyama, K., Liu, S., Abroun, S., Ishikawa, H., Tsuyama, N., Obata, M., Li, F.J., Zheng, X., Maki, Y., Miyamoto, K., Kawano, M.M. Blood (2005) [Pubmed]
  7. Baicalein and baicalin are potent inhibitors of angiogenesis: Inhibition of endothelial cell proliferation, migration and differentiation. Liu, J.J., Huang, T.S., Cheng, W.F., Lu, F.J. Int. J. Cancer (2003) [Pubmed]
  8. Differential effects of natural polyphenols on neuronal survival in primary cultured central neurons against glutamate- and glucose deprivation-induced neuronal death. Lee, H.H., Yang, L.L., Wang, C.C., Hu, S.Y., Chang, S.F., Lee, Y.H. Brain Res. (2003) [Pubmed]
  9. Evaluation of the anti-inflammatory effect of baicalein on dextran sulfate sodium-induced colitis in mice. Hong, T., Jin, G.B., Cho, S., Cyong, J.C. Planta Med. (2002) [Pubmed]
  10. A comparative study on the individual and combined effects of baicalin and jasminoidin on focal cerebral ischemia-reperfusion injury. Zhang, Z.J., Li, P., Wang, Z., Li, P.T., Zhang, W.S., Sun, Z.H., Zhang, X.J., Wang, Y.Y. Brain Res. (2006) [Pubmed]
  11. Protective effects of kampo medicines and baicalin against intestinal toxicity of a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats. Takasuna, K., Kasai, Y., Kitano, Y., Mori, K., Kobayashi, R., Hagiwara, T., Kakihata, K., Hirohashi, M., Nomura, M., Nagai, E. Jpn. J. Cancer Res. (1995) [Pubmed]
  12. Baicalein inhibition of oxidative-stress-induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6. Chen, Y.C., Chow, J.M., Lin, C.W., Wu, C.Y., Shen, S.C. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  13. Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Chen, Y.C., Shen, S.C., Chen, L.G., Lee, T.J., Yang, L.L. Biochem. Pharmacol. (2001) [Pubmed]
  14. Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Ikemoto, S., Sugimura, K., Yoshida, N., Yasumoto, R., Wada, S., Yamamoto, K., Kishimoto, T. Urology (2000) [Pubmed]
  15. Effects of flavonoids extracted from Scutellaria baicalensis Georgi on hemin-nitrite-H2O2 induced liver injury. Zhao, Y., Li, H., Gao, Z., Gong, Y., Xu, H. Eur. J. Pharmacol. (2006) [Pubmed]
  16. The antipyretic effects of baicalin in lipopolysaccharide-evoked fever in rabbits. Tsai, C.C., Lin, M.T., Wang, J.J., Liao, J.F., Huang, W.T. Neuropharmacology (2006) [Pubmed]
  17. Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings. Huang, Y., Wong, C.M., Lau, C.W., Yao, X., Tsang, S.Y., Su, Y.L., Chen, Z.Y. Biochem. Pharmacol. (2004) [Pubmed]
  18. Analysis of baicalein, baicalin and wogonin in Scutellariae radix and its preparation by microemulsion electrokinetic chromatography with 1-butyl-3-methylimizolium tetrafluoborate ionic liquid as additive. Zhang, H., Tian, K., Tang, J., Qi, S., Chen, H., Chen, X., Hu, Z. Journal of chromatography. A. (2006) [Pubmed]
  19. The herbal medicine sho-saiko-to inhibits the growth of malignant melanoma cells by upregulating Fas-mediated apoptosis and arresting cell cycle through downregulation of cyclin dependent kinases. Liu, W., Kato, M., Akhand, A.A., Hayakawa, A., Takemura, M., Yoshida, S., Suzuki, H., Nakashima, I. Int. J. Oncol. (1998) [Pubmed]
  20. Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. Lee, S.O., Jeong, Y.J., Yu, M.H., Lee, J.W., Hwangbo, M.H., Kim, C.H., Lee, I.S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  21. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. Woo, K.J., Lim, J.H., Suh, S.I., Kwon, Y.K., Shin, S.W., Kim, S.C., Choi, Y.H., Park, J.W., Kwon, T.K. Immunobiology (2006) [Pubmed]
  22. Efflux of baicalin, a flavone glucuronide of Scutellariae Radix, on Caco-2 cells through multidrug resistance-associated protein 2. Akao, T., Hanada, M., Sakashita, Y., Sato, K., Morita, M., Imanaka, T. J. Pharm. Pharmacol. (2007) [Pubmed]
  23. Enhancing effects of Scutellaria baicalensis and some of its constituents on TGF-beta1 gene expression in RAW 264.7 murine macrophage cell line. Chuang, H.N., Wang, J.Y., Chiu, J.H., Tsai, T.H., Yeh, S.F., Fu, S.L., Lui, W.Y., Wu, C.W. Planta Med. (2005) [Pubmed]
  24. Application of high-speed counter-current chromatography to the preparative separation and purification of baicalin from the Chinese medicinal plant Scutellaria baicalensis. Lu, H.T., Jiang, Y., Chen, F. Journal of chromatography. A. (2003) [Pubmed]
  25. Preventive effect of Kampo medicine (Hangeshashin-to) against irinotecan-induced diarrhea in advanced non-small-cell lung cancer. Mori, K., Kondo, T., Kamiyama, Y., Kano, Y., Tominaga, K. Cancer Chemother. Pharmacol. (2003) [Pubmed]
  26. Effects of baicalin on the gene expression of surfactant protein A (SP-A) in lung adenocarcinoma cell line H441. Cheng, K.T., Huang, Y.C., Lin, Y.S., Su, B., Chen, C.M. Planta Med. (2003) [Pubmed]
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