Chemical Compound Review:
CHEMBL117470 4-amino-1-[4-hydroxy-5...
Synonyms:
SureCN1651086, SureCN6674896, LS-1031, NSC-127716, NSC-127717, ...
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- 5-azacytidine and 5-azadeoxycytidine inhibit human immunodeficiency virus type 1 replication in vitro. Bouchard, J., Walker, M.C., Leclerc, J.M., Lapointe, N., Beaulieu, R., Thibodeau, L. Antimicrob. Agents Chemother. (1990)
- 5-Aza-2'-deoxycytidine (NSC 127716) in non-seminomatous testicular cancer. Phase II from the EORTC Early Clinical Trials Cooperative Group and Genito-Urinary Group. Clavel, M., Monfardini, S., Fosså, S., Smyth, J., Renard, J., Kaye, S.B. Ann. Oncol. (1992)
- The vast majority of bone-marrow-derived cells integrated into mdx muscle fibers are silent despite long-term engraftment. Wernig, G., Janzen, V., Schäfer, R., Zweyer, M., Knauf, U., Hoegemeier, O., Mundegar, R.R., Garbe, S., Stier, S., Franz, T., Wernig, M., Wernig, A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Parent-of-origin specific histone acetylation and reactivation of a key imprinted gene locus in Prader-Willi syndrome. Saitoh, S., Wada, T. Am. J. Hum. Genet. (2000)
- Epigenetic mechanisms of drug resistance: drug-induced DNA hypermethylation and drug resistance. Nyce, J., Leonard, S., Canupp, D., Schulz, S., Wong, S. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine. Jones, P.A., Taylor, S.M., Mohandas, T., Shapiro, L.J. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene. Chiurazzi, P., Pomponi, M.G., Pietrobono, R., Bakker, C.E., Neri, G., Oostra, B.A. Hum. Mol. Genet. (1999)
- In vitro reactivation of the FMR1 gene involved in fragile X syndrome. Chiurazzi, P., Pomponi, M.G., Willemsen, R., Oostra, B.A., Neri, G. Hum. Mol. Genet. (1998)
- Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents. Bearzatto, A., Szadkowski, M., Macpherson, P., Jiricny, J., Karran, P. Cancer Res. (2000)
- Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis. MacLeod, A.R., Szyf, M. J. Biol. Chem. (1995)
- 5-Azadeoxycytidine-induced chromatin remodeling of the inactive X-linked HPRT gene promoter occurs prior to transcription factor binding and gene reactivation. Litt, M.D., Hansen, R.S., Hornstra, I.K., Gartler, S.M., Yang, T.P. J. Biol. Chem. (1997)
- Kinetochore formation in experimentally undercondensed chromosomes. Haaf, T., Schmid, M. Hum. Genet. (1990)
- Asymmetric methylation in the hypermethylated CpG promoter region of the human L1 retrotransposon. Woodcock, D.M., Lawler, C.B., Linsenmeyer, M.E., Doherty, J.P., Warren, W.D. J. Biol. Chem. (1997)
- Complex relationships between 5-aza-dC induced DNA demethylation and chromosome compaction at mitosis. Flagiello, D., Bernardino-Sgherri, J., Dutrillaux, B. Chromosoma (2002)
- Differential effects of 5-azacytidine and 5-azadeoxycytidine on cytotoxicity, DNA-strand breaking and repair of X-ray-induced DNA damage in HeLa cells. Snyder, R.D., Lachmann, P.J. Mutat. Res. (1989)
- DNA demethylation and pericentromeric rearrangements of chromosome 1. Ji, W., Hernandez, R., Zhang, X.Y., Qu, G.Z., Frady, A., Varela, M., Ehrlich, M. Mutat. Res. (1997)
- Possible involvement of DNA methylation in 5-azacytidine-induced neuronal cell apoptosis. Nakayama, H., Kajikawa, S., Shinozuka, J., Su, W.P., Doi, K. Histol. Histopathol. (1999)
- Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells. Bakker, J., Lin, X., Nelson, W.G. J. Biol. Chem. (2002)
- Studies on hypomethylation of liver DNA during early stages of chemical carcinogenesis in rat liver. Rao, P.M., Antony, A., Rajalakshmi, S., Sarma, D.S. Carcinogenesis (1989)
- Evolutionary conservation of fragile sites induced by 5-azacytidine and 5-azadeoxycytidine in man, gorilla, and chimpanzee. Schmid, M., Ott, G., Haaf, T., Scheres, J.M. Hum. Genet. (1985)
- Effect of 5-aza-2'-deoxycytidine (Dacogen) on covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin promoters in Papio anubis. Lavelle, D., Vaitkus, K., Hankewych, M., Singh, M., DeSimone, J. Exp. Hematol. (2006)
- Selection of drug-resistant transduced cells with cytosine nucleoside analogs using the human cytidine deaminase gene. Beauséjour, C.M., Eliopoulos, N., Momparler, L., Le, N.L., Momparler, R.L. Cancer Gene Ther. (2001)
- Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation. Gratchev, A., Siedow, A., Bumke-Vogt, C., Hummel, M., Foss, H.D., Hanski, M.L., Kobalz, U., Mann, B., Lammert, H., Mansmann, U., Stein, H., Riecken, E.O., Hanski, C. Cancer Lett. (2001)
- Trans-regulated silencing and reactivation of TP53 tumor suppressor gene in malignant transformation and its reversion. Yang, L., Sasaki, M.S. Jpn. J. Cancer Res. (2000)
- DNA methylation alters chromatin structure and regulates Thy-1 expression in EL-4 T cells. Sneller, M.C., Gunter, K.C. J. Immunol. (1987)
- Regulated expression of tumor-specific and MHC class I antigens in an ultraviolet radiation-induced murine skin cancer. Ananthaswamy, H.N. J. Invest. Dermatol. (1988)
- Inhibition of condensation in the late-replicating X chromosome induced by 5-azadeoxycytidine in human lymphocyte cultures. Haaf, T., Ott, G., Schmid, M. Hum. Genet. (1988)