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Chemical Compound Review:

Pregn-sulf (3S,8S,9S,10R,13S,14S,17S)- 17-ethanoyl-10...

Synonyms: CHEBI:35420, AC1L2XZN, LMST05020014, AR-1L1729, CMC_13403, ...

Yanaihara, T. et al., Spence, K.T. et al., Spivak, V. et al., Waters, S.L. et al., Garcia de Yebenes, E. et al.

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High impact information on pregnenolone sulfate

In particular, whereas PS inhibits AMPA and other non-N-methyl-D-aspartate (NMDA) family members, it activates the NMDA receptor [1].
The neurosteroid pregnenolone-sulfate, a negative modulator of the GABAA receptor, also stimulated POMC gene expression [2].
The neurosteroids pregnenolone (PE) and pregnenolone-sulfate (PS) have been shown to interact with the GABAA receptor in the central nervous system [3].
During two consecutive one-hour incubation periods, mean concentrations of 2.23+/-0.45 and 2.77+/-0.60 ng/h/mg tissue (+/-SE) of combined pregnenolone and pregnenolone-sulfate were found in the media of the control group [4].
Maximal protection with AP and 17 alpha-OH-AP was 70%, whereas DHEAS, PS, PREG, and muscimol produced 100% cytoprotection [5].

References

Identification of a neurosteroid binding site contained within the GluR2-S1S2 domain. Spivak, V., Lin, A., Beebe, P., Stoll, L., Gentile, L. Lipids (2004) [Pubmed]
Regulation of proopiomelanocortin gene expression by endogenous ligands of the GABAA receptor complex as evaluated by in situ hybridization in the rat pars intermedia. Garcia de Yebenes, E., Li, S., Pelletier, G. Brain Res. (1997) [Pubmed]
The neurosteroids pregnenolone and pregnenolone-sulfate but not progesterone, block Ca2+ currents in acutely isolated hippocampal CA1 neurons. Spence, K.T., Plata-Salaman, C.R., ffrench-Mullen, J.M. Life Sci. (1991) [Pubmed]
In vitro release of steroids from the human fetal adrenal tissue. Yanaihara, T., Arai, K. Acta obstetricia et gynecologica Scandinavica. (1981) [Pubmed]
Neurosteroid inhibition of cell death. Waters, S.L., Miller, G.W., Aleo, M.D., Schnellmann, R.G. Am. J. Physiol. (1997) [Pubmed]

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