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Chemical Compound Review

DHEA sulfate     (3S,8R,9S,10R,13S,14S)-10,13- dimethyl-17...

Synonyms: Inflarest, DHEAS, DHEA-S, CHEMBL259898, CCRIS 6746, ...
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Disease relevance of Prasterone sulfate


Psychiatry related information on Prasterone sulfate


High impact information on Prasterone sulfate

  • Tissue and cell culture techniques, together with improved steroid assays, revealed that the fetal zone is the primary source of DHEA-S, and that its steroidogenic activity is regulated by ACTH [11].
  • Indirect evidence, based on effects of P450c21 deficiency and maternal estriol concentrations, indicate that the fetal adrenal cortex produces cortisol and DHEA-S early in gestation (6-12 weeks) [11].
  • No significant differences between the two groups were observed for E1, E2, T, DHT, DHEA-S, delta 4-A, LH, FSH, and prolactin [12].
  • RESULTS: Men with diabetes had significantly lower plasma levels of free (4.96 nmol/L compared with 5.58 nmol/L) and total testosterone (14.7 nmol/L compared with 17.4 nmol/L), dihydrotestosterone (428 pg/mL compared with 533 pg/mL), and dehydroepiandrosterone sulfate (DHEA-S) (1.92 mumol/L compared with 2.42 mumol/L) than nondiabetic men [13].
  • In order to clarify the effect of DHEA on myeloma cells, we investigated whether DHEA and DHEA-S could inhibit interleukin-6 (IL-6) production of bone marrow mononuclear cells and the proliferation of myeloma cells from patients with myeloma [14].

Chemical compound and disease context of Prasterone sulfate


Biological context of Prasterone sulfate


Anatomical context of Prasterone sulfate

  • Those findings were among the first indications of the function and physiological role of the human fetal adrenal cortex and led Diczfalusy and co-workers to propose the concept of the feto-placental unit, in which DHEA-S produced by the fetal adrenal cortex is used by the placenta for estrogen synthesis [11].
  • In view of our results this type of cyst, which has been shown to be lined by apocrine epithelium, appears to be characterized by high DHEA-S and EGF levels [25].
  • Therefore, these data revealed that DHEA-S, as well as DHEA, had a direct effect on myeloma and bone marrow stromal cells to inhibit their proliferation and IL-6 production, respectively [14].
  • The level of P-450 HFLa in liver homogenates from human fetuses highly correlated with the activity of DHEA-sulfate 16 alpha-hydroxylase [26].
  • The maintenance of a functional fetal zone in the adrenal gland makes the rhesus infant a suitable model to use in studying the regulation of DHAS secretion and fetal zone morphology [27].

Associations of Prasterone sulfate with other chemical compounds


Gene context of Prasterone sulfate


Analytical, diagnostic and therapeutic context of Prasterone sulfate

  • At all time points after treatment, the DHEA-S levels were significantly higher in patients receiving AG [12].
  • Serum PRL levels rose significantly (P less than 0.05) 3--6 h after ia and 2--6 h after iv administration of DHEA-S but was unchanged in the control group [38].
  • In contrast, serum DHEA-S was negatively associated with WHR (P < 0.02), while A was negatively associated with body mass index (P < 0.02) [28].
  • A cross-sectional study (measuring serum DHAS and DHA only) was then carried out in a series of parous and nulliparous women [39].
  • In the present investigation it was found that human fetal adrenal tissue maintained in organ culture secreted appreciable quantities of dehydroisoandrosterone sulfate (DS) and cortisol [40].


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  7. DHEA-S levels and depressive symptoms in a cohort of African American and Caucasian women in the late reproductive years. Morrison, M.F., Ten Have, T., Freeman, E.W., Sammel, M.D., Grisso, J.A. Biol. Psychiatry (2001) [Pubmed]
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  16. Serum dehydroepiandrosterone sulfate concentrations in secondary adrenal insufficiency. Yamaji, T., Ishibashi, M., Takaku, F., Itabashi, A., Katayama, S., Ishii, J. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  17. Dehydroepiandrosterone sulfate (DHEAS) and testosterone: relation to HIV illness stage and progression over one year. Ferrando, S.J., Rabkin, J.G., Poretsky, L. J. Acquir. Immune Defic. Syndr. (1999) [Pubmed]
  18. Abnormal adrenal steroidogenesis in growth-retarded newborn infants. Parker, C.R., Buchina, E.S., Barefoot, T.K. Pediatr. Res. (1994) [Pubmed]
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  22. Exaggerated adrenarche and hyperinsulinism in adolescent girls born small for gestational age. Ibáñez, L., Potau, N., Marcos, M.V., de Zegher, F. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  23. Vascular dysfunction and metabolic parameters in polycystic ovary syndrome. Meyer, C., McGrath, B.P., Cameron, J., Kotsopoulos, D., Teede, H.J. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  24. Endocrine and morphological maturation of the fetal and neonatal adrenal cortex in baboons. Ducsay, C.A., Hess, D.L., McClellan, M.C., Novy, M.J. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  25. Epidermal growth factor in breast cyst fluid: relationship with intracystic cation and androgen conjugate content. Boccardo, F., Valenti, G., Zanardi, S., Cerruti, G., Fassio, T., Bruzzi, P., De Franchis, V., Barreca, A., Del Monte, P., Minuto, F. Cancer Res. (1988) [Pubmed]
  26. P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate. Kitada, M., Kamataki, T., Itahashi, K., Rikihisa, T., Kanakubo, Y. J. Biol. Chem. (1987) [Pubmed]
  27. Persistence of fetal zone function in the infant rhesus monkey adrenal gland. Serón-Ferré, M., Hess, D.L., Lindholm, U., Jaffe, R.B. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  28. Endogenous androgens and carotid intimal-medial thickness in women. Bernini, G.P., Sgro', M., Moretti, A., Argenio, G.F., Barlascini, C.O., Cristofani, R., Salvetti, A. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  29. Daily hormonal changes in the maternal, fetal, and amniotic fluid compartments before parturition in a primate species. Walsh, S.W., Stanczyk, F.Z., Novy, M.J. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
  30. On the origin of the elevated 17-hydroxyprogesterone levels after adrenal stimulation in hyperandrogenism. Azziz, R., Rafi, A., Smith, B.R., Bradley, E.L., Zacur, H.A. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  31. Early hormonal changes during valproate or carbamazepine treatment: a 3-month study. Rättyä, J., Pakarinen, A.J., Knip, M., Repo-Outakoski, M., Myllylä, V.V., Isojärvi, J.I. Neurology (2001) [Pubmed]
  32. Adrenal steroids in maternal and cord blood after dexamethasone administration at midterm. Charnvises, S., Fencl, M.D., Osathanondh, R., Zhu, M.G., Underwood, R., Tulchinsky, D. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  33. Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells. Smith, R., Mesiano, S., Chan, E.C., Brown, S., Jaffe, R.B. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
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  36. Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients. Maccario, M., Ramunni, J., Oleandri, S.E., Procopio, M., Grottoli, S., Rossetto, R., Savio, P., Aimaretti, G., Camanni, F., Ghigo, E. Int. J. Obes. Relat. Metab. Disord. (1999) [Pubmed]
  37. CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids. Nakamura, H., Torimoto, N., Ishii, I., Ariyoshi, N., Nakasa, H., Ohmori, S., Kitada, M. Drug Metab. Dispos. (2003) [Pubmed]
  38. Intraamniotic or intravenous injection of dehydroepiandrosterone sulfate in midgestation: effect on prolactin level in maternal serum and amniotic fluid. Ylikorkala, O., Kauppila, A., Viinikka, L. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
  39. Long term effects of a first pregnancy on the hormonal environment: estrogens and androgens. Musey, V.C., Collins, D.C., Brogan, D.R., Santos, V.R., Musey, P.I., Martino-Saltzman, D., Preedy, J.R. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  40. The role of serum lipoproteins in steroidogenesis by the human fetal adrenal cortex. Simpson, E.R., Carr, B.R., Parker, C.R., Milewich, L., Porter, J.C., MacDonald, P.C. J. Clin. Endocrinol. Metab. (1979) [Pubmed]
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