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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Cytoprotection


Psychiatry related information on Cytoprotection


High impact information on Cytoprotection

  • Cytoprotection by NF-kappaB involves the activation of pro-survival genes; however, its basis remains poorly understood [8].
  • The anti-inflammatory properties of heme oxygenase-1 may serve as a basis for this cytoprotection [9].
  • As the airway epithelium is morphologically similar and also expresses one of these receptors, PAR2, and is a major source of PGE2, we reasoned that bronchial epithelial PAR2 might also participate in prostanoid-dependent cytoprotection in the airways [10].
  • PGE2 stimulates gastric chloride transport: possible key to cytoprotection [11].
  • These observations suggest that endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection and that sulfhydryl drugs may have potential for preventing or treating hemorrhagic gastric erosions [12].

Chemical compound and disease context of Cytoprotection


Biological context of Cytoprotection


Anatomical context of Cytoprotection

  • In this report the relationship of MCP expression to C3b deposition and cytoprotection was examined using NIH/3T3 cells transfected with human MCP and exposed to human serum as a source of C and naturally occurring anti-mouse antibody [23].
  • Prostaglandin synthesis by the gastric mucosa also does not appear to play a major role in the mechanism of adaptive cytoprotection [24].
  • This study examined the contribution of the "mucoid cap" that forms on the gastric mucosal surface after the application of an irritant to the increased resistance of the mucosa to damage induced by a subsequent application of ethanol ("adaptive cytoprotection") [24].
  • We conclude that in health, mucosal prostaglandin generation in the duodenum is induced post cibum in relation to duodenal acid load; this may be a physiologic example of adaptive cytoprotection [25].
  • These data suggest that salivary gland factors affected adaptive cytoprotection induced by an irritant dose of ethanol [26].

Associations of Cytoprotection with chemical compounds


Gene context of Cytoprotection


Analytical, diagnostic and therapeutic context of Cytoprotection


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  4. Role of intracellular pH during cytoprotection of proximal tubule cells by glycine or acidosis. Weinberg, J.M., Davis, J.A., Roeser, N.F., Venkatachalam, M.A. J. Am. Soc. Nephrol. (1994) [Pubmed]
  5. Anesthetic effects on the glycerol model of rhabdomyolysis-induced acute renal failure in rats. Lochhead, K.M., Kharasch, E.D., Zager, R.A. J. Am. Soc. Nephrol. (1998) [Pubmed]
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  7. Chronic cytoprotection: pentadecapeptide BPC 157, ranitidine and propranolol prevent, attenuate and reverse the gastric lesions appearance in chronic alcohol drinking rats. Prkacin, I., Aralica, G., Perovic, D., Separovic, J., Gjurasin, M., Lovric-Bencic, M., Stancic-Rokotov, D., Ziger, T., Anic, T., Sikiric, P., Seiwerth, S., Staresinic, M., Mise, S., Rotkvic, I., Jagic, V., Rucman, R., Petek, M., Turkovic, B., Marovic, A., Sjekavica, I., Sebecic, B., Boban-Blagaic, A., Ivasovic, Z. J. Physiol. Paris (2001) [Pubmed]
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  9. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Otterbein, L.E., Bach, F.H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R.J., Flavell, R.A., Choi, A.M. Nat. Med. (2000) [Pubmed]
  10. A protective role for protease-activated receptors in the airways. Cocks, T.M., Fong, B., Chow, J.M., Anderson, G.P., Frauman, A.G., Goldie, R.G., Henry, P.J., Carr, M.J., Hamilton, J.R., Moffatt, J.D. Nature (1999) [Pubmed]
  11. PGE2 stimulates gastric chloride transport: possible key to cytoprotection. Schiessel, R., Matthews, J., Barzilai, A., Merhav, A., Silen, W. Nature (1980) [Pubmed]
  12. Sulfhydryl compounds may mediate gastric cytoprotection. Szabo, S., Trier, J.S., Frankel, P.W. Science (1981) [Pubmed]
  13. Cadmium resistance in A549 cells correlates with elevated glutathione content but not antioxidant enzymatic activities. Hatcher, E.L., Chen, Y., Kang, Y.J. Free Radic. Biol. Med. (1995) [Pubmed]
  14. Adenine nucleotides, transport activity and hypoxic necrosis in the thick ascending limb of Henle. Shanley, P.F., Johnson, G.C. Kidney Int. (1989) [Pubmed]
  15. trans-resveratrol protects embryonic mesencephalic cells from tert-butyl hydroperoxide: electron paramagnetic resonance spin trapping evidence for a radical scavenging mechanism. Karlsson, J., Emgard, M., Brundin, P., Burkitt, M.J. J. Neurochem. (2000) [Pubmed]
  16. Modulation of hypoxia-induced calpain activity in rat renal proximal tubules. Edelstein, C.L., Yaqoob, M.M., Alkhunaizi, A.M., Gengaro, P.E., Nemenoff, R.A., Wang, K.K., Schrier, R.W. Kidney Int. (1996) [Pubmed]
  17. Role of endogenous vascular endothelial growth factor in tubular cell protection against acute cyclosporine toxicity. Alvarez Arroyo, M.V., Suzuki, Y., Yagüe, S., Lorz, C., Jiménez, S., Soto, C., Barat, A., Belda, E., González-Pacheco, F.R., Deudero, J.J., Castilla, M.A., Egido, J., Ortiz, A., Caramelo, C. Transplantation (2002) [Pubmed]
  18. Amino acid substitutions can influence the natural killer (NK)-mediated recognition of HLA-C molecules. Role of serine-77 and lysine-80 in the target cell protection from lysis mediated by "group 2" or "group 1" NK clones. Biassoni, R., Falco, M., Cambiaggi, A., Costa, P., Verdiani, S., Pende, D., Conte, R., Di Donato, C., Parham, P., Moretta, L. J. Exp. Med. (1995) [Pubmed]
  19. Hydrogen peroxide-induced renal injury. A protective role for pyruvate in vitro and in vivo. Salahudeen, A.K., Clark, E.C., Nath, K.A. J. Clin. Invest. (1991) [Pubmed]
  20. Conditional expression of mitogen-activated protein kinase phosphatase-1, MKP-1, is cytoprotective against UV-induced apoptosis. Franklin, C.C., Srikanth, S., Kraft, A.S. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  21. Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures. Schroeder, J.J., Cousins, R.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  22. Microsatellite polymorphism in heme oxygenase-1 gene promoter is associated with susceptibility to oxidant-induced apoptosis in lymphoblastoid cell lines. Hirai, H., Kubo, H., Yamaya, M., Nakayama, K., Numasaki, M., Kobayashi, S., Suzuki, S., Shibahara, S., Sasaki, H. Blood (2003) [Pubmed]
  23. Membrane cofactor protein (CD46) protects cells from complement-mediated attack by an intrinsic mechanism. Oglesby, T.J., Allen, C.J., Liszewski, M.K., White, D.J., Atkinson, J.P. J. Exp. Med. (1992) [Pubmed]
  24. Increased resistance of the rat gastric mucosa to hemorrhagic damage after exposure to an irritant. Role of the "mucoid cap" and prostaglandin synthesis. Wallace, J.L. Gastroenterology (1988) [Pubmed]
  25. Duodenal prostaglandin synthesis and acid load in health and in duodenal ulcer disease. Ahlquist, D.A., Dozois, R.R., Zinsmeister, A.R., Malagelada, J.R. Gastroenterology (1983) [Pubmed]
  26. Effect of sialoadenectomy on adaptive cytoprotection in the rat. Tepperman, B.L., Soper, B.D., Morris, G.P. Gastroenterology (1989) [Pubmed]
  27. Identification of subcellular targets and sensitive tests of ethanol-induced damage in isolated rat gastric mucosal cells. Nagy, L., Szabo, S., Morales, R.E., Plebani, M., Jenkins, J.M. Gastroenterology (1994) [Pubmed]
  28. Cysteamine and prostaglandin F2 beta stimulate rat gastric mucin release. Lamont, J.T., Ventola, A.S., Maull, E.A., Szabo, S. Gastroenterology (1983) [Pubmed]
  29. Protective role of intracellular glutathione against ethanol-induced damage in cultured rat gastric mucosal cells. Mutoh, H., Hiraishi, H., Ota, S., Yoshida, H., Ivey, K.J., Terano, A., Sugimoto, T. Gastroenterology (1990) [Pubmed]
  30. Glycine cytoprotection during lethal hepatocellular injury from adenosine triphosphate depletion. Dickson, R.C., Bronk, S.F., Gores, G.J. Gastroenterology (1992) [Pubmed]
  31. Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2. Haraguchi, M., Torii, S., Matsuzawa, S., Xie, Z., Kitada, S., Krajewski, S., Yoshida, H., Mak, T.W., Reed, J.C. J. Exp. Med. (2000) [Pubmed]
  32. Growth retardation, duodenal lesions, and aberrant ileum architecture in triple null mice lacking EGF, amphiregulin, and TGF-alpha. Troyer, K.L., Luetteke, N.C., Saxon, M.L., Qiu, T.H., Xian, C.J., Lee, D.C. Gastroenterology (2001) [Pubmed]
  33. Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis. Zazzeroni, F., Papa, S., Algeciras-Schimnich, A., Alvarez, K., Melis, T., Bubici, C., Majewski, N., Hay, N., De Smaele, E., Peter, M.E., Franzoso, G. Blood (2003) [Pubmed]
  34. Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection. Shen, X.D., Ke, B., Zhai, Y., Gao, F., Anselmo, D., Lassman, C.R., Busuttil, R.W., Kupiec-Weglinski, J.W. Hepatology (2003) [Pubmed]
  35. Induction of endothelial cell decay-accelerating factor by vascular endothelial growth factor: a mechanism for cytoprotection against complement-mediated injury during inflammatory angiogenesis. Mason, J.C., Lidington, E.A., Yarwood, H., Lublin, D.M., Haskard, D.O. Arthritis Rheum. (2001) [Pubmed]
  36. Prostaglandins for peptic ulcer: a promise unfulfilled. Hawkey, C.J., Walt, R.P. Lancet (1986) [Pubmed]
  37. Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease. Rossi, S., Blazar, B.R., Farrell, C.L., Danilenko, D.M., Lacey, D.L., Weinberg, K.I., Krenger, W., Holländer, G.A. Blood (2002) [Pubmed]
  38. Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition. Kim, J.S., Ohshima, S., Pediaditakis, P., Lemasters, J.J. Hepatology (2004) [Pubmed]
  39. Ex vivo exposure to carbon monoxide prevents hepatic ischemia/reperfusion injury through p38 MAP kinase pathway. Amersi, F., Shen, X.D., Anselmo, D., Melinek, J., Iyer, S., Southard, D.J., Katori, M., Volk, H.D., Busuttil, R.W., Buelow, R., Kupiec-Weglinski, J.W. Hepatology (2002) [Pubmed]
  40. Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases. Kang, Y.J., Zhou, Z.X., Wang, G.W., Buridi, A., Klein, J.B. J. Biol. Chem. (2000) [Pubmed]
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