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Chemical Compound Review:

CCRIS 6313 N-[2-methyl-4-(2- methylphenyl)phenyl]hydro...

Synonyms: AG-G-76681, AC1Q7DJL, LS-77412, CTK5D2993, AR-1K7137, ...

Shirai, T. et al., Shirai, T. et al., Flammang, T.J. et al., Kirlin, W.G. et al.

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Disease relevance of CCRIS 6313

Groups of F344 and Wistar rats were given an intraperitoneal injection of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl (N-OH-DMAB) at a dose of 5 mg/kg body weight with a 1-week dietary pretreatment with ethinyl estradiol (EE), and this regimen was repeated 10 times at one-week intervals [1].
Selective induction of prostate carcinomas in F344 rats treated with intraperitoneal injections of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl [1].

High impact information on CCRIS 6313

The human bladder cytosols were also tested for their capacity to activate N-hydroxy-3,2'-dimethyl-4-aminobiphenyl to a DNA-binding electrophile through a direct OAT-mediated catalysis [2].
Acetyl coenzyme A-dependent metabolic activation of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl and several carcinogenic N-hydroxy arylamines in relation to tissue and species differences, other acyl donors, and arylhydroxamic acid-dependent acyltransferases [3].
Groups of F344 rats were administered biweekly intraperitoneal injections of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl (N-OH-DMAB) at a dose of 5, 10 or 20 mg/kg body weight or DMAB, the parent compound, at a dose of 25 mg/kg body weight, for a total of 10 times [4].

References

Selective induction of prostate carcinomas in F344 rats treated with intraperitoneal injections of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl. Shirai, T., Nakamura, A., Fukushima, S., Wang, C.Y., Yamada, H., Ito, N. Jpn. J. Cancer Res. (1990) [Pubmed]
Polymorphic expression of acetyl coenzyme A-dependent arylamine N-acetyltransferase and acetyl coenzyme A-dependent O-acetyltransferase-mediated activation of N-hydroxyarylamines by human bladder cytosol. Kirlin, W.G., Trinidad, A., Yerokun, T., Ogolla, F., Ferguson, R.J., Andrews, A.F., Brady, P.K., Hein, D.W. Cancer Res. (1989) [Pubmed]
Acetyl coenzyme A-dependent metabolic activation of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl and several carcinogenic N-hydroxy arylamines in relation to tissue and species differences, other acyl donors, and arylhydroxamic acid-dependent acyltransferases. Flammang, T.J., Kadlubar, F.F. Carcinogenesis (1986) [Pubmed]
Dose dependence of N-hydroxy-3,2'-dimethyl-4-aminobiphenyl-induced rat prostate carcinogenesis. Shirai, T., Iwasaki, S., Naito, H., Masui, T., Kato, T., Imaida, K. Jpn. J. Cancer Res. (1992) [Pubmed]

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