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Chemical Compound Review:

Tritox 2,2,2-trichloroethanenitrile

Synonyms: WLN: NCXGGG, CCRIS 2671, LS-211, T53805_ALDRICH, AG-F-89329, ...

Mohammed, A. et al., Saari, W.S. et al., Shibaev, V.N. et al., Christ, S.A. et al., Ning, J. et al.

Mohammed, Agard,

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Disease relevance of Trichloromethyl cyanide

The toxicities of six chemicals (cadmium chloride, potassium dichromate, sodium dodecyl sulfate, potassium chloride, Tritox X-100 and copper (II) sulphate) was determined for three tropical freshwater cladoceran, Moinodaphnia macleayi, Ceriodaphnia rigaudii and Diaphanosoma brachyurum [1].

High impact information on Trichloromethyl cyanide

A series of trichloroacetamidine derivatives, obtained by addition of amines to trichloroacetonitrile, was evaluated for positive inotropic activity on isolated cat heart papillary muscles [2].
Acetylation, selective 1-O-deacetylation, and activation with trichloroacetonitrile gave the trisaccharide donor 7 [3].
A simple procedure was developed involving the phosphorylation of aliphatic alcohols with tetra-n-butylammonium dihydrogen phosphate and trichloroacetonitrile [4].
Trichloroacetonitrile (TCAN) is a by-product of the chlorine disinfection of water containing natural organic material [5].

References

Comparative Sensitivity of Three Tropical Cladoceran Species (Diaphanosoma brachyurum, Ceriodaphnia rigaudii and Moinodaphnia macleayi) to Six Chemicals. Mohammed, A., Agard, J.B. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering (2006) [Pubmed]
Trichloroacetamidines, a new class of positive inotropic agents. Saari, W.S., Freedman, M.B., Huff, J.R., King, S.W., Raab, A.W., Bergstrand, S.J., Engelhardt, E.L. J. Med. Chem. (1978) [Pubmed]
Large-scale preparation of the phytoalexin elicitor glucohexatose and its application as a green pesticide. Ning, J., Kong, F., Lin, B., Lei, H. J. Agric. Food Chem. (2003) [Pubmed]
New developments in the synthesis of phosphopolyprenols and their glycosyl esters. Shibaev, V.N., Danilov, L.L. Biochem. Cell Biol. (1992) [Pubmed]
Developmental effects of trichloroacetonitrile administered in corn oil to pregnant Long-Evans rats. Christ, S.A., Read, E.J., Stober, J.A., Smith, M.K. Journal of toxicology and environmental health. (1996) [Pubmed]

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