Disease relevance of Hydrogen

• BACKGROUND: Hydrogen peroxide (H2O2) and reactive oxygen species are implicated in inflammation, ischemia-reperfusion injury, and atherosclerosis [1].
• Characterization of Mutants That Change the Hydrogen Bonding of the Semiquinone Radical at the QH Site of the Cytochrome bo3 from Escherichia coli [2].
• Protein-Cofactor Interactions in Bacterial Reaction Centers from Rhodobacter sphaeroides R-26: II. Geometry of the Hydrogen Bonds to the Primary Quinone Formula by 1H and 2H ENDOR Spectroscopy [3].
• CONCLUSIONS: Hydrogen peroxide is produced in blood plasma and elevation of its level could constitute a pathogenic factor in vascular organ damage attendant upon systemic hypertension [4].
• The mechanism of toxicity of 5-S-cysteinyldopa to tumour cells. Hydrogen peroxide as a mediator of cytotoxicity [5].

High impact information on Hydrogen

• Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity [6].
• (i) Hydrogen exchange experiments show very small protection factors ( approximately 2) for the putative intermediate, indicating a stability of approximately 0.0 kcal/mol [7].
• CONCLUSIONS: Hydrogen peroxide induces concentration-dependent intracellular Ca2+ oscillations in human endothelial cells, which results from release of an endoplasmic reticulum Ca2+ store [8].
• Specific Aquaporins Facilitate the Diffusion of Hydrogen Peroxide across Membranes [9].
• Mapping ERK2-MKP3 Binding Interfaces by Hydrogen/Deuterium Exchange Mass Spectrometry [10].

Chemical compound and disease context of Hydrogen

• Neisseria gonorrhoeae DNA Recombination and Repair Enzymes Protect against Oxidative Damage Caused by Hydrogen Peroxide [11].
• A new bisphosphonate, disodium dihydrogen (cycloheptylamino) methylene bisphosphonate monohydrate (YM175), was compared with 3-amino-1-hydroxypropylidene-1, 1-bisphosphonate (AHPrBP) and 1-hydroxyethylidene-1,1-bisphosphonate (HEBP) in terms of its effect on tumour induced osteolysis using a bladder tumour in mice (MBT-2) [12].
• Local Stability of Rhodobacter capsulatus Cytochrome c(2) Probed by Solution Phase Hydrogen/Deuterium Exchange and Mass Spectrometry [13].
• A hydrogenase associated with dihydrogen uptake (HUP hydrogenase) was purified from an Escherichia coli mutant (strain SE1100) defective in utilization of molybdate and thus fermentative dihydrogen production [14].
• In contrast, HIV-2 reverse transcriptase was observed to be four-fold more sensitive toward the inhibitory effects of the ipecac alkaloids, O-methylpsychotrine sulfate heptahydrate and psychotrine dihydrogen oxalate [15].

Biological context of Hydrogen

• Hydrogenation of the more sterically hindered members of the series furnished free aniline and the previously reported iron dihydrogen complex [16].
• Dihydrogen activation by a diruthenium analogue of the Fe-only hydrogenase active site [17].
• CONCLUSIONS: Hydrogen peroxide gas plasma sterilization may provide a cost-effective means of sterilizing nonlumen electrophysiology catheters without the problem of potentially harmful chemical residuals [18].
• Sequence Dependence of BNIP3 Transmembrane Domain Dimerization Implicates Side-chain Hydrogen Bonding and a Tandem GxxxG Motif in Specific Helix-Helix Interactions [19].
• A systematic investigation of molecular structures/supramolecular organization relationships in dihydrogen-bonded complexes comprising NaBH4 and poly-2-hydroxyethyl-cyclen (poly-HEC) building blocks is reported [20].

Anatomical context of Hydrogen

• Structural basis of human erythrocyte glucose transporter function in reconstituted system. Hydrogen exchange [21].
• To confirm the inhibitory effect of bisphosphonates on osteoclast formation and gain some insights into the underlying mechanisms, we examined the effect of disodium dihydrogen (cycloheptylamino)-methylene-bisphosphonate monohydrate (YM175) on osteoclast-like multinucleated cell (OCL) formation in various mouse coculture systems [22].
• RESULTS: Hydrogen peroxide caused a reversible rise in [Ca2+]i of vascular smooth muscle under both resting conditions and in the precontracted state [23].
• BACKGROUND: Hydrogen peroxide (H2O2) is an important mediator of glomerular injury, which induces proliferation and cell contraction in mesangial cells [24].
• OBJECTIVE: Hydrogen peroxide (H(2)O(2)) produced by the vascular endothelium is a signaling molecule regulating vascular tone [25].

Associations of Hydrogen with other chemical compounds

• The Role of a Conserved Serine Residue within Hydrogen Bonding Distance of FAD in Redox Properties and the Modulation of Catalysis by Ca2+/Calmodulin of Constitutive Nitric-oxide Synthases [26].
• Mechanistic insights into the phosphine-free RuCp*-diamine-catalyzed hydrogenation of aryl ketones: experimental and theoretical evidence for an alcohol-mediated dihydrogen activation [27].
• Single-crystal neutron diffraction, inelastic neutron scattering, and density functional calculations provide experimental and theoretical analyses of the nature of the osmium-bound, "elongated" dihydrogen ligands in [Cp*OsH(4)(L)][BF(4)] complexes (L = PPh(3), AsPh(3), or PCy(3)) [28].
• Geometry of Hydrogen Bonds Formed by Lipid Bilayer Nitroxide Probes: A High-Frequency Pulsed ENDOR/EPR Study [29].
• Exposure of the zirconium hydrides containing the eta5,eta3-4,5-dihydroindenediyl rings to 1 atm of dihydrogen afforded the tetrahydroindenyl zirconium dihydride complexes, establishing the intermediacy of this unusual coordination environment during benzo ring hydrogenation [30].

Gene context of Hydrogen

• RESULTS: Hydrogen peroxide exposure led to mobilization of annexin VI from lipid rafts to the cytosol, which was followed by an increase in cytosolic calcium, phosphorylation of CaMK II, and formation of focal adhesion-like complexes [31].
• The catalytic mechanism of carbonic anhydrase. Hydrogen-isotope effects on the kinetic parameters of the human C isoenzyme [32].
• Activation of Ubiquitin Ligase SCF(Skp2) by Cks1: Insights from Hydrogen Exchange Mass Spectrometry [33].
• The reaction of a [(PHOX)Ir(COD)](+) complex (COD = 1,5-cyclooctadiene) with dihydrogen was studied by NMR spectroscopy (PHOX = chiral phosphinooxazoline ligand) [34].
• PAS Domain Allostery and Light-induced Conformational Changes in Photoactive Yellow Protein upon I(2) Intermediate Formation, Probed with Enhanced Hydrogen/Deuterium Exchange Mass Spectrometry [35].

Analytical, diagnostic and therapeutic context of Hydrogen

• Particularly, the complex IrH(H...H)Cl(2)(P(i)Pr(3))(2) which contains a stretched dihydrogen ligand in the crystalline form, as shown by neutron diffraction, is a trihydride in solution [36].
• Molecular topology and quantum chemical descriptors in the study of reversed-phase liquid chromatography. Hydrogen-bonding behavior of chalcones and flavanones [37].
• Gastric emptying (nuclide gastric emptying studies, liquid and semi-solid test meal), intestinal transit time (Hydrogen breath test with lactulose) and intestinal motor function (perfusion manometry with 8 measuring ports) were determined [38].
• BACKGROUND: Hydrogen peroxide (H2O2) formation is a critical factor in processes involving ischaemia/ reperfusion [39].
• CONCLUSION: Hydrogen peroxide-enhanced ultrasound is superior to physical examination and standard ultrasound in delineating the anatomic course of perianal fistulas [40].

References