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Chemical Compound Review:

APGWamide N-[[(1S)-1-aminocarbonyl-2- (1H-indol-3...

Synonyms: Apgw-amide, LS-172663, AC1L3U7S, C21H28N6O4, 126675-52-3, ...

Liu, G.J. et al., van Tol-Steye, H. et al., Di Cristo, C. et al., Han, X.Y. et al., Croll, R.P. et al., et al.

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Disease relevance of Apgw-amide

Effect of APGW-amide on [Ca2+]i in rat pheochromocytoma PC12 cells [1].

Psychiatry related information on Apgw-amide

The amidated tetrapeptide Ala-Pro-Gly-Trp-NH2 (APGWamide) plays a key role in the control of male copulation behavior in the basommatophoran pulmonate freshwater snail Lymnaea stagnalis [2].

High impact information on Apgw-amide

Here we review and suggest alternate isolation strategies for key players in the imposex induction process: vitellin (Vn), aromatase, and Ala-Pro-Gly-Trp (APGW) amide neurohormone [3].
Co-localized neuropeptides conopressin and ALA-PRO-GLY-TRP-NH2 have antagonistic effects on the vas deferens of Lymnaea [4].
In the present study, the presence of amidated tetrapeptide Ala-Pro-Gly-Trp-NH2 (APGWamide) in those lobes that are involved in the control of reproductive behavior in Octopus vulgaris has been investigated [5].
On the perfused oviduct, GWa appeared to be 3000 times more potent than APGW-amide [6].
These results indicate that APGW-amide elevates [Ca2+]i in PC12 cells, possibly by Ca2+ influx via L-type Ca2+ channel activated by PKC [1].

Biological context of Apgw-amide

In addition, we consider that APGW-amide affects intracellular signal transduction systems or ionic channels, thus modulating these currents [7].

Anatomical context of Apgw-amide

FMRFamide (Phe-Met-Arg-Phe-NH2), APGW-amide (Ala-Pro-Gly-Trp-NH2), oxytocin and [SER2]-Mytilus inhibitory peptide ([SER2]-MIP) (Gly-Ser-Pro-Met-Phe-Val-NH2) were examined on the inward current (Iin) caused by achatin-I (Gly-D-Phe-Ala-Asp), which has been isolated from the Achatina ganglia [8].

Associations of Apgw-amide with other chemical compounds

Dopamine and the neuropeptides Ala-Pro-Gly-Trp-NH2 (APGWamide or APGWa) and Phe-Met-Arg-Phe-NH2 (FMRFamide or FMRFa) all activate an S-like potassium channel in the light green cells of the mollusc Lymnaea stagnalis, neuroendocrine cells that release insulin-related peptides [9].

Gene context of Apgw-amide

Iin induced by oxytocin on PON was not affected by APGW-amide [10].

Analytical, diagnostic and therapeutic context of Apgw-amide

Distribution of the peptide Ala-Pro-Gly-Trp-NH2 (APGWamide) in the nervous system and periphery of the snail Lymnaea stagnalis as revealed by immunocytochemistry and in situ hybridization [11].

References

Effect of APGW-amide on [Ca2+]i in rat pheochromocytoma PC12 cells. Han, X.Y., Ito, Y., Nozawa, Y., Jiang, Y., Matsunami, K. Jpn. J. Pharmacol. (2000) [Pubmed]
Localization of the neuropeptide APGWamide in gastropod molluscs by in situ hybridization and immunocytochemistry. de Lange, R.P., van Minnen, J. Gen. Comp. Endocrinol. (1998) [Pubmed]
Molecular markers of endocrine disruption in aquatic organisms. Rotchell, J.M., Ostrander, G.K. Journal of toxicology and environmental health. Part B, Critical reviews. (2003) [Pubmed]
Co-localized neuropeptides conopressin and ALA-PRO-GLY-TRP-NH2 have antagonistic effects on the vas deferens of Lymnaea. Van Golen, F.A., Li, K.W., De Lange, R.P., Van Kesteren, R.E., Van Der Schors, R.C., Geraerts, W.P. Neuroscience (1995) [Pubmed]
The presence of APGWamide in Octopus vulgaris: a possible role in the reproductive behavior. Di Cristo, C., Van Minnen, J., Di Cosmo, A. Peptides (2005) [Pubmed]
Isolation and identification of a novel Ala-Pro-Gly-Trp-amide-related peptide inhibiting the motility of the mature oviduct in the cuttlefish, Sepia officinalis. Henry, J., Favrel, P., Boucaud-Camou, E. Peptides (1997) [Pubmed]
Modulation by APGW-amide, an Achatina endogenous inhibitory tetrapeptide, of currents induced by neuroactive compounds on Achatina neurons: amines and amino acids. Han, X.Y., Salunga, T.L., Zhang, W., Takeuchi, H., Matsunami, K. Gen. Pharmacol. (1997) [Pubmed]
Suppressing effects of neuroactive peptides on the inward current caused by achatin-I, an Achatina endogenous peptide. Liu, G.J., Takeuchi, H. Gen. Pharmacol. (1995) [Pubmed]
Roles of G-protein beta gamma, arachidonic acid, and phosphorylation inconvergent activation of an S-like potassium conductance by dopamine, Ala-Pro-Gly-Trp-NH2, and Phe-Met-Arg-Phe-NH2. van Tol-Steye, H., Lodder, J.C., Mansvelder, H.D., Planta, R.J., van Heerikhuizen, H., Kits, K.S. J. Neurosci. (1999) [Pubmed]
Modulation by APGW-amide, an Achatina endogenous inhibitory tetrapeptide, of currents induced by neuroactive compounds on Achatina neurons: peptides. Han, X.Y., Salunga, T.L., Zhang, W., Takeuchi, H., Matsunami, K. Gen. Pharmacol. (1997) [Pubmed]
Distribution of the peptide Ala-Pro-Gly-Trp-NH2 (APGWamide) in the nervous system and periphery of the snail Lymnaea stagnalis as revealed by immunocytochemistry and in situ hybridization. Croll, R.P., Van Minnen, J. J. Comp. Neurol. (1992) [Pubmed]

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