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Chemical Compound Review

Amdoxovir     [(2R,4R)-4-(2,6-diaminopurin- 9-yl)-1,3...

Synonyms: DAPD, CHEMBL458876, SureCN141228, DAPD cpd, AC1L3XUG, ...
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Disease relevance of Amdoxovir


High impact information on Amdoxovir


Analytical, diagnostic and therapeutic context of Amdoxovir

  • Overall, the enzymatic data correlated well with the antiviral data obtained from cell culture experiments and further supported the use of amdoxovir for the treatment of nucleoside reverse transcriptase inhibitor-experienced patients [3].


  1. Amdoxovir versus placebo with enfuvirtide plus optimized background therapy for HIV-1-infected subjects failing current therapy (AACTG A5118). Gripshover, B.M., Ribaudo, H., Santana, J., Gerber, J.G., Campbell, T.B., Hogg, E., Jarocki, B., Hammer, S.M., Kuritzkes, D.R. Antivir. Ther. (Lond.) (2006) [Pubmed]
  2. Enzymatic assay for measurement of intracellular DXG triphosphate concentrations in peripheral blood mononuclear cells from human immunodeficiency virus type 1-infected patients. Kewn, S., Wang, L.H., Hoggard, P.G., Rousseau, F., Hart, R., MacNeela, J.P., Khoo, S.H., Back, D.J. Antimicrob. Agents Chemother. (2003) [Pubmed]
  3. Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses. Jeffrey, J.L., Feng, J.Y., Qi, C.C., Anderson, K.S., Furman, P.A. J. Biol. Chem. (2003) [Pubmed]
  4. In vitro combination of amdoxovir and the inosine monophosphate dehydrogenase inhibitors mycophenolic acid and ribavirin demonstrates potent activity against wild-type and drug-resistant variants of human immunodeficiency virus type 1. Borroto-Esoda, K., Myrick, F., Feng, J., Jeffrey, J., Furman, P. Antimicrob. Agents Chemother. (2004) [Pubmed]
  5. Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases. Feng, J.Y., Parker, W.B., Krajewski, M.L., Deville-Bonne, D., Veron, M., Krishnan, P., Cheng, Y.C., Borroto-Esoda, K. Biochem. Pharmacol. (2004) [Pubmed]
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