Gene Review:
IMPDH1 - IMP (inosine 5'-monophosphate)...
Homo sapiens
Synonyms:
IMP dehydrogenase 1, IMPD, IMPD 1, IMPD1, IMPDH 1, ...
Dryja,
Humphries,
Ette,
Szekeres,
McHutchison,
Abrahamson,
Metz,
Novotny,
Yee,
Schatz,
Wright,
Alam,
McNair,
McGee,
Akkina,
Ponjavic,
Zaia,
Yam,
Espling,
Andréasson,
Shiffman,
Gu,
Mortimer,
Kennan,
Wolner,
Hughbanks-Wheaton,
Tran,
Johnson,
Mitchell,
Kiang,
Jensen,
Tamai,
Daiger,
Sullivan,
Weigel,
Wu,
Kenna,
Zhu,
Kemp,
Anderson,
Lloyd,
Spellicy,
Heckenlively,
Ayuso,
Brockenbrough,
Sato,
Hedstrom,
Rabaglia,
Farrar,
Sedlak,
Cheung,
Engel,
Birch,
Wada,
Lewis,
Gordon,
Kawamura,
Villacres,
Itabashi,
Alberts,
Bowne,
Humphries,
Gire,
Holland,
Segu,
Aherne,
Tada,
Bertalanffy,
McNally,
Moseley,
Pottage,
- Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis. Bowne, S.J., Sullivan, L.S., Mortimer, S.E., Hedstrom, L., Zhu, J., Spellicy, C.J., Gire, A.I., Hughbanks-Wheaton, D., Birch, D.G., Lewis, R.A., Heckenlively, J.R., Daiger, S.P. Invest. Ophthalmol. Vis. Sci. (2006)
- Screening for mutations in the IMPDH1 gene in Japanese patients with autosomal dominant retinitis pigmentosa. Wada, Y., Tada, A., Itabashi, T., Kawamura, M., Sato, H., Tamai, M. Am. J. Ophthalmol. (2005)
- Clinical phenotype in a Swedish family with a mutation in the IMPDH1 gene. Schatz, P., Ponjavic, V., Andréasson, S., McGee, T.L., Dryja, T.P., Abrahamson, M. Ophthalmic Genet. (2005)
- Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration? Bowne, S.J., Liu, Q., Sullivan, L.S., Zhu, J., Spellicy, C.J., Rickman, C.B., Pierce, E.A., Daiger, S.P. Invest. Ophthalmol. Vis. Sci. (2006)
- Increased inosine-5'-phosphate dehydrogenase gene expression in solid tumor tissues and tumor cell lines. Collart, F.R., Chubb, C.B., Mirkin, B.L., Huberman, E. Cancer Res. (1992)
- Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid. Sintchak, M.D., Fleming, M.A., Futer, O., Raybuck, S.A., Chambers, S.P., Caron, P.R., Murcko, M.A., Wilson, K.P. Cell (1996)
- Bateman domains and adenosine derivatives form a binding contract. Kemp, B.E. J. Clin. Invest. (2004)
- Sensitization of human erythroleukemia K562 cells resistant to methotrexate by inhibiting IMPDH. Peñuelas, S., Noé, V., Morales, R., Ciudad, C.J. Med. Sci. Monit. (2005)
- In vitro combination studies of tenofovir and other nucleoside analogues with ribavirin against HIV-1. Margot, N.A., Miller, M.D. Antivir. Ther. (Lond.) (2005)
- A randomized, double-blind, placebo-controlled dose-escalation trial of merimepodib (VX-497) and interferon-alpha in previously untreated patients with chronic hepatitis C. McHutchison, J.G., Shiffman, M.L., Cheung, R.C., Gordon, S.C., Wright, T.L., Pottage, J.C., McNair, L., Ette, E., Moseley, S., Alam, J. Antivir. Ther. (Lond.) (2005)
- Differentiation of androgen-independent prostate cancer PC-3 cells is associated with increased nuclear factor-kappaB activity. Floryk, D., Huberman, E. Cancer Res. (2005)
- Purine metabolism of human glioblastoma in vivo. Pillwein, K., Chiba, P., Knoflach, A., Czermak, B., Schuchter, K., Gersdorf, E., Ausserer, B., Murr, C., Goebl, R., Stockhammer, G. Cancer Res. (1990)
- On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa. Aherne, A., Kennan, A., Kenna, P.F., McNally, N., Lloyd, D.G., Alberts, I.L., Kiang, A.S., Humphries, M.M., Ayuso, C., Engel, P.C., Gu, J.J., Mitchell, B.S., Farrar, G.J., Humphries, P. Hum. Mol. Genet. (2004)
- Assignment of the human type I IMP dehydrogenase gene (IMPDH1) to chromosome 7q31.3-q32). Gu, J.J., Kaiser-Rogers, K., Rao, K., Mitchell, B.S. Genomics (1994)
- Identification and regional localization of a human IMP dehydrogenase-like locus (IMPDHL1) at 16p13.13. Doggett, N.A., Callen, D.F., Chen, Z.L., Moore, S., Tesmer, J.G., Duesing, L.A., Stallings, R.L. Genomics (1993)
- Chromosomal localization and structure of the human type II IMP dehydrogenase gene (IMPDH2). Glesne, D., Collart, F., Varkony, T., Drabkin, H., Huberman, E. Genomics (1993)
- Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa. Bowne, S.J., Sullivan, L.S., Blanton, S.H., Cepko, C.L., Blackshaw, S., Birch, D.G., Hughbanks-Wheaton, D., Heckenlively, J.R., Daiger, S.P. Hum. Mol. Genet. (2002)
- Characterization of the human inosine-5'-monophosphate dehydrogenase type II gene. Zimmermann, A.G., Spychala, J., Mitchell, B.S. J. Biol. Chem. (1995)
- Inosine-5'-monophosphate dehydrogenase is required for mitogenic competence of transformed pancreatic beta cells. Metz, S., Holland, S., Johnson, L., Espling, E., Rabaglia, M., Segu, V., Brockenbrough, J.S., Tran, P.O. Endocrinology (2001)
- Ex vivo selection and expansion of cells based on expression of a mutated inosine monophosphate dehydrogenase 2 after HIV vector transduction: effects on lymphocytes, monocytes, and CD34+ stem cells. Yam, P., Jensen, M., Akkina, R., Anderson, J., Villacres, M.C., Wu, J., Zaia, J.A., Yee, J.K. Mol. Ther. (2006)
- PKB/Akt interacts with inosine-5' monophosphate dehydrogenase through its pleckstrin homology domain. Ingley, E., Hemmings, B.A. FEBS Lett. (2000)
- Benzamide riboside, a recent inhibitor of inosine 5'-monophosphate dehydrogenase induces transferrin receptors in cancer cells. Szekeres, T., Sedlak, J., Novotny, L. Current medicinal chemistry. (2002)
- Role of differentiation induction in action of purine antimetabolites. Weber, G., Hata, Y., Prajda, N. Pharmacy world & science : PWS. (1994)
- Screen of the IMPDH1 gene among patients with dominant retinitis pigmentosa and clinical features associated with the most common mutation, Asp226Asn. Wada, Y., Sandberg, M.A., McGee, T.L., Stillberger, M.A., Berson, E.L., Dryja, T.P. Invest. Ophthalmol. Vis. Sci. (2005)
- Depletion of intracellular GTP results in nuclear factor-kappaB activation and intercellular adhesion molecule-1 expression in human endothelial cells. Weigel, G., Bertalanffy, P., Wolner, E. Mol. Pharmacol. (2002)
- IMP dehydrogenase type 1 associates with polyribosomes translating rhodopsin mRNA. Mortimer, S.E., Xu, D., McGrew, D., Hamaguchi, N., Lim, H.C., Bowne, S.J., Daiger, S.P., Hedstrom, L. J. Biol. Chem. (2008)
- Two distinct cDNAs for human IMP dehydrogenase. Natsumeda, Y., Ohno, S., Kawasaki, H., Konno, Y., Weber, G., Suzuki, K. J. Biol. Chem. (1990)
- Cloning and sequence analysis of the human and Chinese hamster inosine-5'-monophosphate dehydrogenase cDNAs. Collart, F.R., Huberman, E. J. Biol. Chem. (1988)