The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

SureCN3911587     2-[(4-methoxy-3-methyl- pyridin-2...

Synonyms: AC1L2UIH, AR-1D7268, BY 308, AC1Q4K3M, B-823-08, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of BY 308

 

High impact information on BY 308

  • BY 308 significantly increased serum gastrin levels, gastrin cell density, and antral gastrin concentration [2].
  • Hypergastrinemia accompanied by increased antral gastrin and reduced antral and fundic somatostatin concentrations was also found in vivo after 4 wk of treatment with BY 308 [1].
  • BY 308 treatment resulted in a marked induction of HDC and CgA mRNA, whereas concomitant PD 136 450 in a concentration previously shown to suppress maximal pentagastrin-induced gastric acid secretion and to prevent BY 308-induced ECL cell proliferation did not result in significant alteration [3].
 

Biological context of BY 308

 

Anatomical context of BY 308

  • Both serum gastrin levels and G-cell density further increased after 3 and 8 days' treatment with BY 308 whereas the somatostatin (D)-cell count did not change prior to 8 days' administration [5].
 

Associations of BY 308 with other chemical compounds

References

  1. Influence of chronic drug-induced achlorhydria by substituted benzimidazoles on the endocrine stomach in rats. Koop, H., Willemer, S., Steinbach, F., Eissele, R., Tuch, K., Arnold, R. Gastroenterology (1987) [Pubmed]
  2. Effect of gastrin receptor blockade on endocrine cells in rats during achlorhydria. Eissele, R., Patberg, H., Koop, H., Krack, W., Lorenz, W., McKnight, A.T., Arnold, R. Gastroenterology (1992) [Pubmed]
  3. Effect of gastrin receptor blockade on gastrin and histidine decarboxylase gene expression in rats during achlorhydria. Simon, B., Eissele, R., Czornik, M., Swarovsky, B., Arnold, R. Scand. J. Gastroenterol. (1995) [Pubmed]
  4. Proliferation of endocrine cells in the rat stomach caused by drug-induced achlorhydria. Eissele, R., Rosskopf, B., Koop, H., Adler, G., Arnold, R. Gastroenterology (1991) [Pubmed]
  5. Increased visualization of antral gastrin-producing G-cells after acute stimulation of gastrin release in the rat. Koop, H., Schubert, B., Schwarting, H., Schikierka, D., Eissele, R., Willemer, S., Arnold, R. Eur. J. Clin. Invest. (1987) [Pubmed]
 
WikiGenes - Universities