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Chemical Compound Review

SureCN3911587     2-[(4-methoxy-3-methyl- pyridin-2...

Synonyms: AC1L2UIH, AR-1D7268, BY 308, AC1Q4K3M, B-823-08, ...
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Disease relevance of BY 308


High impact information on BY 308

  • BY 308 significantly increased serum gastrin levels, gastrin cell density, and antral gastrin concentration [2].
  • Hypergastrinemia accompanied by increased antral gastrin and reduced antral and fundic somatostatin concentrations was also found in vivo after 4 wk of treatment with BY 308 [1].
  • BY 308 treatment resulted in a marked induction of HDC and CgA mRNA, whereas concomitant PD 136 450 in a concentration previously shown to suppress maximal pentagastrin-induced gastric acid secretion and to prevent BY 308-induced ECL cell proliferation did not result in significant alteration [3].

Biological context of BY 308


Anatomical context of BY 308

  • Both serum gastrin levels and G-cell density further increased after 3 and 8 days' treatment with BY 308 whereas the somatostatin (D)-cell count did not change prior to 8 days' administration [5].

Associations of BY 308 with other chemical compounds


  1. Influence of chronic drug-induced achlorhydria by substituted benzimidazoles on the endocrine stomach in rats. Koop, H., Willemer, S., Steinbach, F., Eissele, R., Tuch, K., Arnold, R. Gastroenterology (1987) [Pubmed]
  2. Effect of gastrin receptor blockade on endocrine cells in rats during achlorhydria. Eissele, R., Patberg, H., Koop, H., Krack, W., Lorenz, W., McKnight, A.T., Arnold, R. Gastroenterology (1992) [Pubmed]
  3. Effect of gastrin receptor blockade on gastrin and histidine decarboxylase gene expression in rats during achlorhydria. Simon, B., Eissele, R., Czornik, M., Swarovsky, B., Arnold, R. Scand. J. Gastroenterol. (1995) [Pubmed]
  4. Proliferation of endocrine cells in the rat stomach caused by drug-induced achlorhydria. Eissele, R., Rosskopf, B., Koop, H., Adler, G., Arnold, R. Gastroenterology (1991) [Pubmed]
  5. Increased visualization of antral gastrin-producing G-cells after acute stimulation of gastrin release in the rat. Koop, H., Schubert, B., Schwarting, H., Schikierka, D., Eissele, R., Willemer, S., Arnold, R. Eur. J. Clin. Invest. (1987) [Pubmed]
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