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Chemical Compound Review:

AC1L2XKD 4-amino-1-[(2R,3S,4S)-2,3- dihydroxy-4...

Synonyms: AR-1G0491, AC1Q6C6F, Carbocyclic cytidine

Shealy, Y.F. et al., De Clercq, E. et al., Huang, M. et al., Glazer, R.I. et al.

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Disease relevance of Carbodine

5-Bromocarbodine was active against influenza virus, but it was less active than carbodine [1].
Carbodine, 5-bromocarbodine, C-2'-deoxycytidine, C-5-bromo-2'-deoxycytidine, the four C-5-iodocytosine nucleosides, and C-ara-C inhibited replication of this strain of HSV-1 in cultured cells [1].
Carbocyclic cytidine (C-Cyd) is a broad-spectrum antiviral agent active against DNA viruses [pox (vaccinia)], (+)RNA viruses [toga (Sindbis, Semliki forest), corona], (-)RNA viruses [orthomyxo (influenza), paramyxo (parainfluenza, measles), rhabdo (vesicular stomatitis)] and (+/-)RNA viruses (reo) [2].

High impact information on Carbodine

Cyclopentenyl cytosine (CPEC) is a carbocyclic cytidine analog inhibitor of CTP synthetase and experimental drug for combination chemotherapy [3].
In tests against these DNA viruses, carbodine, a ribofuranoside analogue that had been shown previously to be highly active against human influenza A virus in vitro, was the most active compound against HSV-2 and one of the most active compounds against HSV-1 in Vero cells [1].
Continuous exposure for 5 days to 10(-8) to 10(-6) M cCyd or 10(-6) to 10(-5) M carbodine produced progressive inhibition of cell growth [4].

References

Carbocyclic analogues of 5-halocytosine nucleosides. Shealy, Y.F., O'Dell, C.A., Arnett, G., Shannon, W.M., Thorpe, M.C., Riordan, J.M., Coburn, W.C. J. Med. Chem. (1986) [Pubmed]
Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine. De Clercq, E., Bernaerts, R., Shealy, Y.F., Montgomery, J.A. Biochem. Pharmacol. (1990) [Pubmed]
CPEC induces erythroid differentiation of human myeloid leukemia K562 cells through CTP depletion and p38 MAP kinase. Huang, M., Wang, Y., Collins, M., Graves, L.M. Leukemia (2004) [Pubmed]
Induction of differentiation in the human promyelocytic leukemia cell line HL-60 by the cyclopentenyl analogue of cytidine. Glazer, R.I., Cohen, M.B., Hartman, K.D., Knode, M.C., Lim, M.I., Marquez, V.E. Biochem. Pharmacol. (1986) [Pubmed]

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