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Chemical Compound Review:

ACPD 1-aminocyclopentane-1,3- dicarboxylic acid

Synonyms: SureCN235442, ACMC-1C3II, AG-A-00025, AG-F-37806, ACMC-20bhyc, ...

Fundytus, M.E. et al., Ohno, M. et al., Shinoda, Y. et al., Zalewska, A. et al., Collins, D.R. et al., et al.

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Psychiatry related information on 1-aminocyclopentane-1,3-dicarboxylic acid

2. In the present study, we showed that acute i.c.v. administration of the non-selective mGluR agonist 1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD), as well as the group II selective agonist (2S,1'R,2'R,3'R)-2-(2'.3'-dicarboxycyclopropyl)glycine (DCG-IV), significantly attenuated the severity of precipitated withdrawal symptoms [1].

High impact information on 1-aminocyclopentane-1,3-dicarboxylic acid

Using the selective mGluR agonist 1-aminocyclopentane-1,3-dicarboxylic acid (1s,3R-ACPD), considerable progress has been made towards understanding the role of this glutamate receptor class in the central nervous system [2].
Intracerebral microdialysis technique was utilized to study the effect of the metabotropic glutamate receptor agonist, 1-aminocyclopentane-1,3-dicarboxylic acid (ACDP), on extracellular dopamine concentration in the nucleus accumbens of unanesthetized, freely moving rats [3].
The broad-spectrum mGluR agonist 1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) decreased the frequency of GABA(A)-mediated spontaneous PSCs in a reversible manner [4].
The influence of intracerebroventricular (i.c.v.) injections of 1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), an agonist of metabotropic glutamate receptors, on the activity of the central nervous system was examined in rats [5].

Associations of 1-aminocyclopentane-1,3-dicarboxylic acid with other chemical compounds

LTD was induced pharmacologically 1-3 times at 24-h intervals by applying aseptically ACPD (1-aminocyclopentane-1,3-dicarboxylic acid), an agonist of group I/II mGluR, and APV (2-amino-5-phosphonovalerate), an antagonist of the NMDA (N-methyl-D-aspartate) receptor [6].

Analytical, diagnostic and therapeutic context of 1-aminocyclopentane-1,3-dicarboxylic acid

We have shown that, providing the CA3 region remains attached to the slice, it is possible to induce potentiation by bath perfusion of the metabotropic receptor agonist (1S,3R) 1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) alone [7].

References

Attenuation of precipitated morphine withdrawal symptoms by acute i.c.v. administration of a group II mGluR agonist. Fundytus, M.E., Coderre, T.J. Br. J. Pharmacol. (1997) [Pubmed]
Metabotropic glutamate receptors in brain function and pathology. Schoepp, D.D., Conn, P.J. Trends Pharmacol. Sci. (1993) [Pubmed]
Persistent increase in dopamine release following activation of metabotropic glutamate receptors in the rat nucleus accumbens. Ohno, M., Watanabe, S. Neurosci. Lett. (1995) [Pubmed]
Endogenous activation of metabotropic glutamate receptors modulates GABAergic transmission to gonadotropin-releasing hormone neurons and alters their firing rate: a possible local feedback circuit. Chu, Z., Moenter, S.M. J. Neurosci. (2005) [Pubmed]
Behavioral activity of 1S,3R-ACPD, an agonist of metabotropic glutamate receptors. Zalewska, A., Wiśniewski, K. Polish journal of pharmacology. (1997) [Pubmed]
Repetition of mGluR-dependent LTD causes slowly developing persistent reduction in synaptic strength accompanied by synapse elimination. Shinoda, Y., Kamikubo, Y., Egashira, Y., Tominaga-Yoshino, K., Ogura, A. Brain Res. (2005) [Pubmed]
Indirect potentiation of synaptic transmission by metabotropic glutamate receptors in the rat hippocampal slice. Collins, D.R., Scollon, J.M., Russell, D.C., Davies, S.N. Brain Res. (1995) [Pubmed]

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