Disease relevance of Methylmethionine

• The preventive effect of dimethyl-beta-propiothetin (DMPT) and methylmethionine at 5 mM each on stress-induced gastric ulcers in rats was compared [1].

High impact information on Methylmethionine

• However, whereas alpha-methylmethionine sulfoximine and methionine sulfoximine inhibit gamma-glutamylcysteine synthetase markedly, alpha-ethylmethionine sulfoximine does not, nor does administration of the alpha-ethyl analog produce the decrease in tissue glutathione levels found after giving methionine sulfoximine or its alpha-methyl analog [2].
• Upstream of yagD and overlapping with its reading frame is a gene (ykfD) which, when inactivated, also blocks growth on methylmethionine in a metE metH genetic background [3].
• One is in the metP gene, which accounts for resistance to alpha-methylmethionine, and the other is in a gene designated glnP which results in reduced L-glutamine transport [4].
• The methyltransferase activity was assessed by measuring the incorporation of [3H]methyl moiety into phospholipids in sensitized mast cells labelled with L-[3H] methylmethionine. cAMP level was measured by radioimmunoassay [5].

Analytical, diagnostic and therapeutic context of Methylmethionine

• The ulcer index of test rats in the DMPT group was noticeably lower, compared with those in the methylmethionine and the control groups [1].

References