Disease relevance of NSC 42386

• Increased attachment of the 1,3-propanesultone-treated DNA to the microsomal membrane and enhanced adsorption to and penetration into Ehrlich ascites tumor cells were also observed [1].
• When administered either prior to propane sultone treatment or in a mixture with it, the seedling injury, chromosomal aberrations, mutations per 100 M1 spikes as well as M2 chlorophyll mutation frequency, were enhanced [2].
• The quantitative relationship between carcinogenicity in rodents and mutagenicity in Salmonella typhimurium was examined, by using 10 monofunctional alkylating agents, including N-nitrosamides, alkyl methanesulfonates, epoxides, beta-propiolactone and 1,3-propane sultone [3].
• Propane sultone was also included because its effect on plants is suppressed by hyperthermia [4].
• As cerebral gliomas are the main systemic tumours induced by 1,3-propane sultone experimentally, the occurrence of a glioblastoma among previously exposed persons appears conspicuous [5].

High impact information on NSC 42386

• Induction of anchorage-independent growth in human fibroblasts by propane sultone [6].
• We have demonstrated a dose-dependent increase in the frequency of diploid human cells capable of anchorage-independent (AI) growth after treatment with the carcinogen propane sultone, followed by exponential growth to allow full expression of this phenotype (8 to 13 population doublings) [6].
• A15 is derived from a tertiary amine, with one alkylic substituent (either C11 or C13) and two poly(ethylene oxide) tails (totaling 15 ethoxy residues), which is reacted with propane sultone [7].
• Caffeine potentiation of propane sultone mutagenesis in barley [8].
• Original data are presented on the efficacy of twenty potential cancer chemopreventive agents were screened for efficacy in the HEC Assay. Efficacy was determined by the ability of agents, at nontoxic concentrations, to reverse either of the propane sultone-induced biomarkers, enhanced growth and reduced involucrin expression [9].

Biological context of NSC 42386

• Induction of chromosomal aberrations and sister chromatid exchanges by propane sultone in human lymphocytes in vitro [10].

Anatomical context of NSC 42386

• Primary cultures of human foreskin keratinocytes were prepared and exposed to the carcinogen, propane sultone [11].

Gene context of NSC 42386

• Genotoxicological investigation of 1,3-propane sultone was undertaken using human lymphocyte cultures as the test system [10].
• Sulfonations using propane sultone were performed directly onto PU or onto hydrophobic dodecanediol (DDO) grafted PU or onto hydrophilic poly(ethyleneoxide) (PEO) grafted PU [12].

Analytical, diagnostic and therapeutic context of NSC 42386

• The Zwittergent preparations were treated with NaOH in order to destroy any propane sultone residue and this was checked by HPLC [13].

References