Disease relevance of niclosamide

• The influence of selected environmental parameters on the toxicity of Bayluscide to Schistosoma mansoni miracidia [1].
• Several workers have advocated the integrated approach to schistosomiasis control, including snail control, but the death and decay of aquatic organisms, and fish kill that often follows Bayluscide application at the dose of 1 g/m3 decrease its acceptability [2].

High impact information on niclosamide

• The biology and toxicology of molluscicides, Bayluscide [3].
• In the last 10 years, there has been general agreement that niclosamide (bayluscide) is the preferred molluscicide for control of the snails transmitting Schistosoma mansoni and Schistosoma haematobium [4].
• Helisoma trivolvis and Biomphalaria havanensis were selected as test organisms due to the lack of intermediate snail hosts in the U.S. Using Bayluscide as a reference molluscicidal compound, malathion was tested against snail eggs, juveniles, and adults [5].
• Further studies are needed to assess the cost-effectiveness of Bayluscide in the control of schistosomiasis following the simplified approach [2].
• The present study was designed to assess the effect of lower Bayluscide doses on snail host and non-target fish, frog, the tadpole kill [2].

Chemical compound and disease context of niclosamide

• Toxicity evaluation of Bayluscide and malathion to three developmental stages of freshwater snails [5].
• The aim of this study was to determine the toxicity of niclosamide (Bayluscide (R)) on Melanoides tuberculata and Biomphalaria glabrata under laboratory conditions [6].

Biological context of niclosamide

• Bayluscide application caused significant and highly significant reduction in the fecundity of both Physa acuta and Helisoma duryi [7].

Associations of niclosamide with other chemical compounds

• Effect of prolonged administration of sublethal concentrations of aridanin isolated from Tetrapleura tetraptera and bayluscide on the glycogen and protein content of Biomphalaria glabrata [8].

Gene context of niclosamide

• The accumulation in muscles and the effect of different concentrations of niclosamide (Bayluscide) on the metabolic enzymes; succinate dehydrogenase (SDH), pyruvate dehydrogenase (PDH) and lactate dehydrogenase (LDH) in the liver of the Thin-lip grey mullet after 1, 2 & 3 weeks were studied [9].

References