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Chemical Compound Review

SureCN1703377     (Z)-3-(4-hydroxy-3-methoxy- phenyl)prop-2...

Synonyms: CHEBI:76117, bmse010061, NSC-674320, NSC674320, AC1LU7GS, ...
 
 
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High impact information on ferulic acid

  • To release FA from food matrices, it is necessary to cleave ester cross-linking by feruloyl esterase (FAE) (hydroxycinnamoyl esterase; EC 3.1.1.73) [1].
  • When perfused at 15 microM, the secretion of conjugates back to the lumen represented 6.2% of the net transfer into the enterocytes for FA compared to 25.5 and 20 % for genistein and hesperetin respectively [2].
  • However, FA largely differed from the two flavonoids by its low intestinal secretion of conjugates [2].
  • The capacity of a leonardite humic acid (LHA), a soil humic acid (SHA), and a soil fulvic acid (SFA) in modulating the allelopathic potential of caffeic acid (CA), ferulic acid (FA), and salicylic acid (SA) on seedlings of lettuce (Lactuca sativa L.) and tomato (Lycopersicon esculentum Mill.) was investigated [3].
  • Additionally, comparison with the results of other studies revealed that high contents of FA and, especially, diferulic acids in cereal bran, which act as cross-links between bran cell wall polysaccharides, may not improve but, rather, limit the bioavailabilities of PAs in vivo [4].
 

Biological context of ferulic acid

  • Furthermore, the N-terminal amino acid sequence of the purified FAE was found to be A R V E K P R K V I L V G D G A V G S T. The FAE released FA from O-(5-O-feruloyl-alpha-L-arabinofuranosyl)-(1-->3)-O-beta-D-xylopyranosyl-(1-->4)-D-xylopyranose (FAXX) and FAA obtained from refined corn bran [1].
  • These findings indicate that oral ingestion of GCE or 5-CQA decreases blood pressure in SHR, and that FA, which is a metabolite of 5-CQA, is a candidate hypotensive component [5].
 

Anatomical context of ferulic acid

  • By contrast, approximately 81% of FA and approximately 64% of PCA ingested with the single meal were excreted through the rat feces within 3 days after the ingestion [4].
 

Associations of ferulic acid with other chemical compounds

References

  1. Purification and characterization of a feruloyl esterase from the intestinal bacterium Lactobacillus acidophilus. Wang, X., Geng, X., Egashira, Y., Sanada, H. Appl. Environ. Microbiol. (2004) [Pubmed]
  2. The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites. Silberberg, M., Morand, C., Mathevon, T., Besson, C., Manach, C., Scalbert, A., Remesy, C. European journal of nutrition. (2006) [Pubmed]
  3. Humic substances can modulate the allelopathic potential of caffeic, ferulic, and salicylic acids for seedlings of lettuce (Lactuca sativa L.) and tomato (Lycopersicon esculentum Mill.). Loffredo, E., Monaci, L., Senesi, N. J. Agric. Food Chem. (2005) [Pubmed]
  4. Phenolic antioxidants richly contained in corn bran are slightly bioavailable in rats. Zhao, Z., Egashira, Y., Sanada, H. J. Agric. Food Chem. (2005) [Pubmed]
  5. Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats. Suzuki, A., Kagawa, D., Ochiai, R., Tokimitsu, I., Saito, I. Hypertens. Res. (2002) [Pubmed]
  6. Thermal stability of texture in Chinese water chestnut may be dependent on 8,8'-diferulic acid (aryltetralyn form). Parker, C.C., Parker, M.L., Smith, A.C., Waldron, K.W. J. Agric. Food Chem. (2003) [Pubmed]
 
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