The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

SureCN43601     3-(4-hydroxyphenyl)prop-2- enoic acid

Synonyms: Enamine_005378, AG-C-92010, AG-F-57147, ACMC-20aiyh, ANW-30931, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Hydroxycinnamic acid


High impact information on Hydroxycinnamic acid


Chemical compound and disease context of Hydroxycinnamic acid


Biological context of Hydroxycinnamic acid

  • Metabolism of ferulic acid to vanillin. A bacterial gene of the enoyl-SCoA hydratase/isomerase superfamily encodes an enzyme for the hydration and cleavage of a hydroxycinnamic acid SCoA thioester [16].
  • Acylation of anthocyanins with hydroxycinnamic acid derivatives is one of the most important and less under-stood modification reactions during anthocyanin biosynthesis [17].
  • We developed a system for rapid mutagenesis and heterologous bacterial expression for PYP apoprotein and generated holoprotein through formation of a covalent thioester linkage with the p-hydroxycinnamic acid chromophore as found in the native protein [18].
  • The multisite character of transport kinetics was not modified by either hydroxycinnamic acid (CIN) or p-chloromercuribenzylsulfonic acid (PCMBS), which exert different types of inhibition [19].
  • Both phenolics caused a reduction in cell size (P less than 0.05), and p-coumaric acid caused a reduction in capsular size (P less than 0.05) and produced occasional pleomorphic cells [5].

Anatomical context of Hydroxycinnamic acid


Associations of Hydroxycinnamic acid with other chemical compounds


Gene context of Hydroxycinnamic acid


Analytical, diagnostic and therapeutic context of Hydroxycinnamic acid


  1. The xanthopsins: a new family of eubacterial blue-light photoreceptors. Kort, R., Hoff, W.D., Van West, M., Kroon, A.R., Hoffer, S.M., Vlieg, K.H., Crielaand, W., Van Beeumen, J.J., Hellingwerf, K.J. EMBO J. (1996) [Pubmed]
  2. Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Louie, G.V., Bowman, M.E., Moffitt, M.C., Baiga, T.J., Moore, B.S., Noel, J.P. Chem. Biol. (2006) [Pubmed]
  3. Chemical reactivity and spectroscopy of the thiol ester-linked p-coumaric acid chromophore in the photoactive yellow protein from Ectothiorhodospira halophila. Hoff, W.D., Devreese, B., Fokkens, R., Nugteren-Roodzant, I.M., Van Beeumen, J., Nibbering, N., Hellingwerf, K.J. Biochemistry (1996) [Pubmed]
  4. Knockout of the p-coumarate decarboxylase gene from Lactobacillus plantarum reveals the existence of two other inducible enzymatic activities involved in phenolic acid metabolism. Barthelmebs, L., Divies, C., Cavin, J.F. Appl. Environ. Microbiol. (2000) [Pubmed]
  5. Effect of phenolic monomers on ruminal bacteria. Borneman, W.S., Akin, D.E., VanEseltine, W.P. Appl. Environ. Microbiol. (1986) [Pubmed]
  6. Photoreceptor proteins, "star actors of modern times": a review of the functional dynamics in the structure of representative members of six different photoreceptor families. van der Horst, M.A., Hellingwerf, K.J. Acc. Chem. Res. (2004) [Pubmed]
  7. Activation tagging identifies a conserved MYB regulator of phenylpropanoid biosynthesis. Borevitz, J.O., Xia, Y., Blount, J., Dixon, R.A., Lamb, C. Plant Cell (2000) [Pubmed]
  8. Targeted down-regulation of cytochrome P450 enzymes for forage quality improvement in alfalfa (Medicago sativa L.). Reddy, M.S., Chen, F., Shadle, G., Jackson, L., Aljoe, H., Dixon, R.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. A novel multifunctional O-methyltransferase implicated in a dual methylation pathway associated with lignin biosynthesis in loblolly pine. Li, L., Popko, J.L., Zhang, X.H., Osakabe, K., Tsai, C.J., Joshi, C.P., Chiang, V.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  10. Rewriting the lignin roadmap. Humphreys, J.M., Chapple, C. Curr. Opin. Plant Biol. (2002) [Pubmed]
  11. Effects of common forage phenolic acids on Escherichia coli O157:H7 viability in bovine feces. Wells, J.E., Berry, E.D., Varel, V.H. Appl. Environ. Microbiol. (2005) [Pubmed]
  12. Production of plant-specific flavanones by Escherichia coli containing an artificial gene cluster. Hwang, E.I., Kaneko, M., Ohnishi, Y., Horinouchi, S. Appl. Environ. Microbiol. (2003) [Pubmed]
  13. Production of resveratrol in recombinant microorganisms. Beekwilder, J., Wolswinkel, R., Jonker, H., Hall, R., de Vos, C.H., Bovy, A. Appl. Environ. Microbiol. (2006) [Pubmed]
  14. Genetic analysis of a chromosomal region containing vanA and vanB, genes required for conversion of either ferulate or vanillate to protocatechuate in Acinetobacter. Segura, A., Bünz, P.V., D'Argenio, D.A., Ornston, L.N. J. Bacteriol. (1999) [Pubmed]
  15. Co-production of caffeic acid and p-hydroxybenzoic acid from p-coumaric acid by Streptomyces caeruleus MTCC 6638. Sachan, A., Ghosh, S., Sen, S.K., Mitra, A. Appl. Microbiol. Biotechnol. (2006) [Pubmed]
  16. Metabolism of ferulic acid to vanillin. A bacterial gene of the enoyl-SCoA hydratase/isomerase superfamily encodes an enzyme for the hydration and cleavage of a hydroxycinnamic acid SCoA thioester. Gasson, M.J., Kitamura, Y., McLauchlan, W.R., Narbad, A., Parr, A.J., Parsons, E.L., Payne, J., Rhodes, M.J., Walton, N.J. J. Biol. Chem. (1998) [Pubmed]
  17. cDNA cloning, gene expression and subcellular localization of anthocyanin 5-aromatic acyltransferase from Gentiana triflora. Fujiwara, H., Tanaka, Y., Yonekura-Sakakibara, K., Fukuchi-Mizutani, M., Nakao, M., Fukui, Y., Yamaguchi, M., Ashikari, T., Kusumi, T. Plant J. (1998) [Pubmed]
  18. Active site mutants implicate key residues for control of color and light cycle kinetics of photoactive yellow protein. Genick, U.K., Devanathan, S., Meyer, T.E., Canestrelli, I.L., Williams, E., Cusanovich, M.A., Tollin, G., Getzoff, E.D. Biochemistry (1997) [Pubmed]
  19. Pyruvate shuttle in muscle cells: high-affinity pyruvate transport sites insensitive to trans-lactate efflux. Mengual, R., El Abida, K., Mouaffak, N., Rieu, M., Beaudry, M. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
  20. Spectral tuning, fluorescence, and photoactivity in hybrids of photoactive yellow protein, reconstituted with native or modified chromophores. Kroon, A.R., Hoff, W.D., Fennema, H.P., Gijzen, J., Koomen, G.J., Verhoeven, J.W., Crielaard, W., Hellingwerf, K.J. J. Biol. Chem. (1996) [Pubmed]
  21. Phenolic components of the primary cell wall. Feruloylated disaccharides of D-galactose and L-arabinose from spinach polysaccharide. Fry, S.C. Biochem. J. (1982) [Pubmed]
  22. Prooxidant DNA breakage induced by caffeic acid in human peripheral lymphocytes: Involvement of endogenous copper and a putative mechanism for anticancer properties. Bhat, S.H., Azmi, A.S., Hadi, S.M. Toxicol. Appl. Pharmacol. (2007) [Pubmed]
  23. Goitrogenic activity of p-coumaric acid in rats. Khelifi-Touhami, F., Taha, R.A., Badary, O.A., Lezzar, A., Hamada, F.M. J. Biochem. Mol. Toxicol. (2003) [Pubmed]
  24. Two cinnamate derivatives produce similar alteration in mRNA expression and activity of antioxidant enzymes in rats. Lee, M.K., Park, E.M., Bok, S.H., Jung, U.J., Kim, J.Y., Park, Y.B., Huh, T.L., Kwon, O.S., Choi, M.S. J. Biochem. Mol. Toxicol. (2003) [Pubmed]
  25. Functional characterization and subcellular localization of poplar (Populus trichocarpa x Populus deltoides) cinnamate 4-hydroxylase. Ro, D.K., Mah, N., Ellis, B.E., Douglas, C.J. Plant Physiol. (2001) [Pubmed]
  26. Arabidopsis CYP98A3 mediating aromatic 3-hydroxylation. Developmental regulation of the gene, and expression in yeast. Nair, R.B., Xia, Q., Kartha, C.J., Kurylo, E., Hirji, R.N., Datla, R., Selvaraj, G. Plant Physiol. (2002) [Pubmed]
  27. Expression patterns conferred by tyrosine/dihydroxyphenylalanine decarboxylase promoters from opium poppy are conserved in transgenic tobacco. Facchini, P.J., Penzes-Yost, C., Samanani, N., Kowalchuk, B. Plant Physiol. (1998) [Pubmed]
  28. Kinetic studies on the hydroxylation of p-coumaric acid to caffeic acid by spinach-beet phenolase. McIntyre, R.J., Vaughan, P.F. Biochem. J. (1975) [Pubmed]
  29. Generation of hydrogen peroxide, superoxide and hydroxyl radicals during the oxidation of dihydroxyfumaric acid by peroxidase. Halliwell, B. Biochem. J. (1977) [Pubmed]
  30. Modulation of luteinizing hormone receptors: effect of an inhibitor of prolactin secretion, p-coumaric acid. Chowdhury, M., Kabir, S.N., Pal, A.K., Pakrashi, A. J. Endocrinol. (1983) [Pubmed]
  31. Inhibition of human low-density lipoprotein oxidation by caffeic acid and other hydroxycinnamic acid derivatives. Nardini, M., D'Aquino, M., Tomassi, G., Gentili, V., Di Felice, M., Scaccini, C. Free Radic. Biol. Med. (1995) [Pubmed]
  32. Changes in secondary metabolism and deposition of an unusual lignin in the ref8 mutant of Arabidopsis. Franke, R., Hemm, M.R., Denault, J.W., Ruegger, M.O., Humphreys, J.M., Chapple, C. Plant J. (2002) [Pubmed]
  33. Purification and characterization of ferulate and p-coumarate decarboxylase from Bacillus pumilus. Degrassi, G., Polverino De Laureto, P., Bruschi, C.V. Appl. Environ. Microbiol. (1995) [Pubmed]
  34. Cloning, deletion, and characterization of PadR, the transcriptional repressor of the phenolic acid decarboxylase-encoding padA gene of Lactobacillus plantarum. Gury, J., Barthelmebs, L., Tran, N.P., Diviès, C., Cavin, J.F. Appl. Environ. Microbiol. (2004) [Pubmed]
  35. Mechanism of reaction of nitrogen dioxide radical with hydroxycinnamic acid derivatives: a pulse radiolysis study. Zhouen, Z., Side, Y., Weizhen, L., Wenfeng, W., Yizun, J., Nianyun, L. Free Radic. Res. (1998) [Pubmed]
  36. Quantitation of steryl ferulate and p-coumarate esters from corn and rice. Norton, R.A. Lipids (1995) [Pubmed]
  37. Effect of water treatment on analyte and matrix ion yields in matrix-assisted time-of-flight secondary ion mass spectrometry: the case of insulin in and on hydroxycinnamic acid. Szymczak, W., Wittmaack, K. Rapid Commun. Mass Spectrom. (2002) [Pubmed]
WikiGenes - Universities