Disease relevance of Isoflavanone

• WS-7528, a new isoflavanone with estrogen activity isolated from Streptomyces sp. No. 7528. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities [1].
• Synergistic effects of mupirocin and an isoflavanone isolated from Erythrina variegata on growth and recovery of methicillin-resistant Staphylococcus aureus [2].

High impact information on Isoflavanone

• Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula [3].
• Analysis of circular dichroism (CD) spectra of the reduction product sophorol obtained using the recombinant enzyme indicated that the isoflavanone possessed the 3R stereochemistry, in contrast to previous reports indicating a 3S-isoflavanone as the product of the pea IFR [4].
• These findings show that 4'-hydroxylation results in either no change or very little change in IC50 for flavanone, isoflavone and isoflavanone as well as other ring A hydroxylated flavones [5].
• Bioassay-guided fractionation of the extract using a GAL-4-PPAR-gamma chimera assay method resulted in the isolation of two isoflavenes, one of which is a new compound named dehydroglyasperin D, an isoflavan, two 3-arylcoumarins, and an isoflavanone as the PPAR-gamma ligand-binding active ingredients of licorice [6].
• Three minor flavonoids, licofuranocoumarin, isotrifoliol and glisoflavanone, were isolated from licorice (underground part of Glycyrrhiza uralensis), and their structures with 3-arylcoumarin, coumestan and isoflavanone skeletons were respectively elucidated on the basis of spectroscopic data [7].

Associations of Isoflavanone with other chemical compounds

• In addition to the two known compounds neotautenol [2] and erythrinassinate B [4], two new compounds, an isoflavanone named sigmoidin J [1] and a coumestan derivative named sigmoidin K [3], have been isolated and characterized from the root bark of the Cameroonian medicinal plant Erythrina sigmoidea [8].
• A novel prenylated isoflavanone, sigmoidin I, has been isolated from the roots of Erythrina sigmoidea, in addition to the known isoflavones, corylin and neobavaisoflavone and the known pterocarpan, phaseollidin [9].
• Dou-chi, a traditional soybean food fermented with Aspergillus sp., is usually used as a seasoning in Chinese food, and has also been used as a folk medicine in China and Taiwan. As 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavengers, four phenol compounds, one isoflavanone, eight isoflavones and one 4-pyrone have been isolated from dou-chi [10].

References