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Disease relevance of Glycyrrhiza


High impact information on Glycyrrhiza


Chemical compound and disease context of Glycyrrhiza


Biological context of Glycyrrhiza


Anatomical context of Glycyrrhiza


Associations of Glycyrrhiza with chemical compounds

  • In this study, we showed that nonaqueous fractions of licorice (Glycyrrhiza uralensis Fisher) extracted with ethanol, ethyl acetate and acetone, but not an aqueous extract, had PPAR-gamma ligand-binding activity with a GAL4-PPAR-gamma chimera assay [20].
  • The effect of the consumption of glabridin, an isoflavan isolated from Glycyrrhiza glabra (licorice) root, on the susceptibility of low density lipoprotein (LDL) to oxidation was studied in atherosclerotic apolipoprotein E deficient (E[o] mice) and was compared with that of the known flavonoids, quercetin and catechin [21].
  • One step isolation and purification of liquiritigenin and isoliquiritigenin from Glycyrrhiza uralensis Risch. using high-speed counter-current chromatography [22].
  • Comparative estimation of glycyrrhetinic acid content of Lonchocarpus cyanescens and glycyrrhiza roots [23].
  • Two compounds in the W fraction were identified by comparison with authentic samples as 8,9-dihydroxydihydromagnolol and liquiritigenin, metabolites previously isolated from M. officinalis and Glycyrrhiza glabra, respectively [24].

Gene context of Glycyrrhiza


Analytical, diagnostic and therapeutic context of Glycyrrhiza


  1. Molecular and biochemical characterization of 2-hydroxyisoflavanone dehydratase. Involvement of carboxylesterase-like proteins in leguminous isoflavone biosynthesis. Akashi, T., Aoki, T., Ayabe, S. Plant Physiol. (2005) [Pubmed]
  2. Preparative purification of glycyrrhizin extracted from the root of liquorice using high-speed counter-current chromatography. Jiang, Y., Lu, H.T., Chen, F. Journal of chromatography. A. (2004) [Pubmed]
  3. Inhibition of mutagenicity in Salmonella typhimurium by Glycyrrhiza glabra extract, glycyrrhizinic acid, 18 alpha- and 18 beta-glycyrrhetinic acids. Zani, F., Cuzzoni, M.T., Daglia, M., Benvenuti, S., Vampa, G., Mazza, P. Planta Med. (1993) [Pubmed]
  4. Inhibitory effects of licochalcone A isolated from Glycyrrhiza inflata root on inflammatory ear edema and tumour promotion in mice. Shibata, S., Inoue, H., Iwata, S., Ma, R.D., Yu, L.J., Ueyama, H., Takayasu, J., Hasegawa, T., Tokuda, H., Nishino, A. Planta Med. (1991) [Pubmed]
  5. Mechanism of action of glycyrrhizic acid in inhibition of Epstein-Barr virus replication in vitro. Lin, J.C. Antiviral Res. (2003) [Pubmed]
  6. Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection. De Clercq, E. Medicinal research reviews. (2000) [Pubmed]
  7. Cloning and expression of flavone synthase II from Gerbera hybrids. Martens, S., Forkmann, G. Plant J. (1999) [Pubmed]
  8. Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Vaya, J., Belinky, P.A., Aviram, M. Free Radic. Biol. Med. (1997) [Pubmed]
  9. cDNA cloning and expression of isoflavonoid-specific glucosyltransferase from Glycyrrhiza echinata cell-suspension cultures. Nagashima, S., Inagaki, R., Kubo, A., Hirotani, M., Yoshikawa, T. Planta (2004) [Pubmed]
  10. Glycyrrhiza glabra extract as an effector of interception in Escherichia coli K12+. Kuo, S., Shankel, D.M., Telikepalli, H., Mitscher, L.A. Mutat. Res. (1992) [Pubmed]
  11. Anthocyanin-producing dandelion callus as a chalcone synthase source in recombinant polyketide reductase assay. Akashi, T., Saito, N., Hirota, H., Ayabe, S. Phytochemistry (1997) [Pubmed]
  12. Prevention and management of prostate cancer using PC-SPES: a scientific perspective. Hsieh, T.C., Lu, X., Chea, J., Wu, J.M. J. Nutr. (2002) [Pubmed]
  13. Microbial transformation of glycyrrhetinic acid by Mucor polymorphosporus. Xin, X., Liu, Y., Ye, M., Guo, H., Guo, D. Planta Med. (2006) [Pubmed]
  14. Pectic polysaccharides from roots of Glycyrrhiza uralensis: possible contribution of neutral oligosaccharides in the galacturonase-resistant region to anti-complementary and mitogenic activities. Kiyohara, H., Takemoto, N., Zhao, J.F., Kawamura, H., Yamada, H. Planta Med. (1996) [Pubmed]
  15. Chalcone isomerase isozymes with different substrate specificities towards 6'-hydroxy- and 6'-deoxychalcones in cultured cells of Glycyrrhiza echinata, a leguminous plant producing 5-deoxyflavonoids. Kimura, Y., Aoki, T., Ayabe, S. Plant Cell Physiol. (2001) [Pubmed]
  16. Up-regulation of soyasaponin biosynthesis by methyl jasmonate in cultured cells of Glycyrrhiza glabra. Hayashi, H., Huang, P., Inoue, K. Plant Cell Physiol. (2003) [Pubmed]
  17. A novel neutral polysaccharide having activity on the reticuloendothelial system from the root of Glycyrrhiza uralensis. Shimizu, N., Tomoda, M., Kanari, M., Gonda, R., Satoh, A., Satoh, N. Chem. Pharm. Bull. (1990) [Pubmed]
  18. Protection of mitochondrial functions against oxidative stresses by isoflavans from Glycyrrhiza glabra. Haraguchi, H., Yoshida, N., Ishikawa, H., Tamura, Y., Mizutani, K., Kinoshita, T. J. Pharm. Pharmacol. (2000) [Pubmed]
  19. Activation of macrophages by crude polysaccharide fractions obtained from shoots of Glycyrrhiza glabra and hairy roots of Glycyrrhiza uralensis in vitro. Nose, M., Terawaki, K., Oguri, K., Ogihara, Y., Yoshimatsu, K., Shimomura, K. Biol. Pharm. Bull. (1998) [Pubmed]
  20. A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats. Mae, T., Kishida, H., Nishiyama, T., Tsukagawa, M., Konishi, E., Kuroda, M., Mimaki, Y., Sashida, Y., Takahashi, K., Kawada, T., Nakagawa, K., Kitahara, M. J. Nutr. (2003) [Pubmed]
  21. The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. Belinky, P.A., Aviram, M., Fuhrman, B., Rosenblat, M., Vaya, J. Atherosclerosis (1998) [Pubmed]
  22. One step isolation and purification of liquiritigenin and isoliquiritigenin from Glycyrrhiza uralensis Risch. using high-speed counter-current chromatography. Ma, C.J., Li, G.S., Zhang, D.L., Liu, K., Fan, X. Journal of chromatography. A. (2005) [Pubmed]
  23. Comparative estimation of glycyrrhetinic acid content of Lonchocarpus cyanescens and glycyrrhiza roots. Iwu, M.M. Journal of pharmaceutical sciences. (1982) [Pubmed]
  24. A strategy for discovering biologically active compounds with high probability in traditional Chinese herb remedies: an application of saiboku-to in bronchial asthma. Homma, M., Oka, K., Yamada, T., Niitsuma, T., Ihto, H., Takahashi, N. Anal. Biochem. (1992) [Pubmed]
  25. cDNA cloning and biochemical characterization of S-adenosyl-L-methionine: 2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase, a critical enzyme of the legume isoflavonoid phytoalexin pathway. Akashi, T., Sawada, Y., Shimada, N., Sakurai, N., Aoki, T., Ayabe, S. Plant Cell Physiol. (2003) [Pubmed]
  26. Effects of glycyrrhizin on renal functions in association with the regulation of water channels. Kang, D.G., Sohn, E.J., Lee, H.S. Am. J. Chin. Med. (2003) [Pubmed]
  27. Angiogenic and proliferative effects of the cytokine VEGF in Ehrlich ascites tumor cells is inhibited by Glycyrrhiza glabra. Sheela, M.L., Ramakrishna, M.K., Salimath, B.P. Int. Immunopharmacol. (2006) [Pubmed]
  28. Identification of tyrosinase inhibitors from Glycyrrhiza uralensis. Kim, H.J., Seo, S.H., Lee, B.G., Lee, Y.S. Planta Med. (2005) [Pubmed]
  29. CYP81E1, a cytochrome P450 cDNA of licorice (Glycyrrhiza echinata L.), encodes isoflavone 2'-hydroxylase. Akashi, T., Aoki, T., Ayabe, S. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  30. Determination of liquiritigenin and isoliquiritigenin in Glycyrrhiza uralensis and its medicinal preparations by capillary electrophoresis with electrochemical detection. Cao, Y., Wang, Y., Ji, C., Ye, J. Journal of chromatography. A. (2004) [Pubmed]
  31. Inhibition by licochalcone A, a novel flavonoid isolated from liquorice root, of IL-1beta-induced PGE2 production in human skin fibroblasts. Furuhashi, I., Iwata, S., Shibata, S., Sato, T., Inoue, H. J. Pharm. Pharmacol. (2005) [Pubmed]
  32. Molecular cloning and characterization of a cDNA for Glycyrrhiza glabra cycloartenol synthase. Hayashi, H., Hiraoka, N., Ikeshiro, Y., Kushiro, T., Morita, M., Shibuya, M., Ebizuka, Y. Biol. Pharm. Bull. (2000) [Pubmed]
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