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Chemical Compound Review:

Putreanine 3-(4-aminobutylamino)propanoic acid

Synonyms: AC1L4PJX, AC1Q5WEX, AR-1J8927, AR-1J8928, AKOS005216076, ...

Kawase, H. et al., Chideckel, E.W. et al., Fussi, F. et al.

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High impact information on Putreanine

This discovery strongly suggests the existence of a metabolic pathway connecting polyamines and GABA via putreanine and CEGABA through progressive oxidative deamination of the amino terminal groups in spermidine [1].
Polyamines and putreanine relax respiratory tract smooth muscle in the guinea-pig [2].
Spermidine, spermine, and putreanine, a metabolite of spermidine, caused transient relaxation of the isolated guinea-pig trachealis [2].
Incorporation of radioactivity into putreanine, isoputreanine, spermidic acid, and N-aminopropylpyrrolidin-2-one was confirmed by ion-exchange chromatography, thin layer chromatography, and paper electrophoresis, the highest radioactivity being observed in the non-polar and acidic fraction of the collected urine [3].

References

Identification of N-carboxyethyl gamma-aminobutyric acid in bovine brain and human cerebrospinal fluid. Fussi, F., Savoldi, F., Curti, M. Neurosci. Lett. (1987) [Pubmed]
Polyamines and putreanine relax respiratory tract smooth muscle in the guinea-pig. Chideckel, E.W., Fedan, J.S., Mike, P. Eur. J. Pharmacol. (1985) [Pubmed]
A study on the metabolism of spermidine in mammals: purification and identification of a newly identified metabolite, 2-oxo-1-pyrrolidinepropionic acid, in rat urine. Kawase, H., Hasegawa, T., Hashimoto, H., Noto, T., Nakajima, T. J. Biochem. (1994) [Pubmed]

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