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Chemical Compound Review:

Mqmkkvlds (3S)-3-[[2-[[(2S)-2-[[6- amino-2-[[(2S)-6...

Synonyms: Antiflammin 1, Antiflamin 1, Antiflammin P1, AR-1J3346, AC1L4U5N, ...

Mize, N.K. et al., Gao, J. et al., Camussi, G. et al., Rivers, D.B. et al.

Mize, Buttery, Ruis, Leung, Cormier, Daddona, Rivers, Rocco, Frayha,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MET-GLN-MET-LYS-LYS-VAL-LEU-ASP-SER

5. The excitatory response to 10-6 M ATP was abolished by treatment with either pertussis toxin (100 ng ml-1), antiflammin-1 (10-9 M), indomethacin (3x10-6 M) or SQ29548 (3x10-7 M), inhibitors of specific G proteins, phospholipase A2, cyclo-oxygenase and thromboxane A2 receptors respectively [1].
Antiflammin 1 delivered by iontophoresis significantly decreased, but did not eliminate, the erythema associated with co-delivery of an irritating drug compound [2].

High impact information on MET-GLN-MET-LYS-LYS-VAL-LEU-ASP-SER

This finding suggests that antiflammin-1 is inactivated by neutrophils secretory products, possibly oxidizing agents [3].
The peptide MQMKKVLDS (antiflammin-1) is less inhibitory than antiflammin-2 for macrophages and not inhibitory for neutrophils after a 5-min preincubation [3].
A model drug irritant, chlorpromazine, was co-delivered with and without antiflammin 1 by iontophoresis to hairless guinea pigs transdermally [2].
Anti-inflammatory peptide 1 (antiflammin 1) but not bromophenacyl bromide, agents that block phospholipase A2 (PLA2) activity, abolished the responsiveness of BTI-TN-5B1-4 cells to venom [4].

Analytical, diagnostic and therapeutic context of MET-GLN-MET-LYS-LYS-VAL-LEU-ASP-SER

Antiflammin 1 peptide delivered non-invasively by iontophoresis reduces irritant-induced inflammation in vivo [2].

References

Evidence that the ATP-induced increase in vasomotion of guinea-pig mesenteric lymphatics involves an endothelium-dependent release of thromboxane A2. Gao, J., Zhao, J., Rayner, S.E., Van Helden, D.F. Br. J. Pharmacol. (1999) [Pubmed]
Antiflammin 1 peptide delivered non-invasively by iontophoresis reduces irritant-induced inflammation in vivo. Mize, N.K., Buttery, M., Ruis, N., Leung, I., Cormier, M., Daddona, P. Exp. Dermatol. (1997) [Pubmed]
Antiinflammatory peptides (antiflammins) inhibit synthesis of platelet-activating factor, neutrophil aggregation and chemotaxis, and intradermal inflammatory reactions. Camussi, G., Tetta, C., Bussolino, F., Baglioni, C. J. Exp. Med. (1990) [Pubmed]
Venom from the ectoparasitic wasp Nasonia vitripennis increases Na+ influx and activates phospholipase C and phospholipase A2 dependent signal transduction pathways in cultured insect cells. Rivers, D.B., Rocco, M.M., Frayha, A.R. Toxicon (2002) [Pubmed]

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