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Chemical Compound Review:

Cacodylate (methyl-oxido-arsoryl)methane

Synonyms: Kakodylat, Moncide, Arsecodile, Bolate, Ansar, ...

This record was replaced with 2513.

Styblo, M. et al., Jenkins, R.O. et al., Steinmaus, C. et al., Hopenhayn-Rich, C. et al., Hanlon, D.P. et al., et al.

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Disease relevance of cacodylic acid

Lysed-cell extract of a Pseudomonas sp. was shown to catalyse bioconversion of dimethylarsinoylacetate to arsenobetaine and dimethylarsinate [1].

High impact information on cacodylic acid

In this investigation, the distribution of urinary inorganic arsenic, monomethylarsonate, and dimethylarsinate was used to assess intraindividual variation in methylation capacity in 81 subjects with low to moderate arsenic exposures [2].
Arsenobetaine biodegradation by pure cultures was biphasic, with dimethylarsinoylacetate accumulating in culture supernatants during the culture growth phase and its removal accompanying dimethylarsinate formation during a carbon-limited stationary phase [3].
Addition of exogenous glutathione to the assay system (up to 20 mM) decreased protein binding of arsenic and increased the production of methylarsonate and dimethylarsinate [4].
Production of methylarsonate and dimethylarsinate from radiolabelled [73 As]arsenite and [73 As]arsenate was examined in an assay system that contained cytosol prepared from a 20% homogenate (w/v) of livers from 8- 10-week-old male Fischer 344 rats [4].

Associations of cacodylic acid with other chemical compounds

Urinary speciation analysis is used to assess the distribution of metabolites [monomethylarsonate (MMA), dimethylarsinate (DMA), and unmethylated arsenic (InAs)], as indicators of methylation capacity [5].
Both arsenite and dimethylarsinate (DMA) were present in plasma 0.20 hr postinjection, indicating that arsenate reduction and methylation of arsenic are rapidly initiated [6].

References

An origin for arsenobetaine involving bacterial formation of an arsenic-carbon bond. Ritchie, A.W., Edmonds, J.S., Goessler, W., Jenkins, R.O. FEMS Microbiol. Lett. (2004) [Pubmed]
Intraindividual variability in arsenic methylation in a U.S. population. Steinmaus, C., Yuan, Y., Kalman, D., Atallah, R., Smith, A.H. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
Bacterial degradation of arsenobetaine via dimethylarsinoylacetate. Jenkins, R.O., Ritchie, A.W., Edmonds, J.S., Goessler, W., Molenat, N., Kuehnelt, D., Harrington, C.F., Sutton, P.G. Arch. Microbiol. (2003) [Pubmed]
Mono- and dimethylation of arsenic in rat liver cytosol in vitro. Styblo, M., Delnomdedieu, M., Thomas, D.J. Chem. Biol. Interact. (1996) [Pubmed]
Methylation study of a population environmentally exposed to arsenic in drinking water. Hopenhayn-Rich, C., Biggs, M.L., Smith, A.H., Kalman, D.A., Moore, L.E. Environ. Health Perspect. (1996) [Pubmed]
Concentration and chemical status of arsenic in the blood of pregnant hamsters during critical embryogenesis. 2. Acute exposure. Hanlon, D.P., Ferm, V.H. Environmental research. (1986) [Pubmed]

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