Disease relevance of alpha-Triglycidyl isocyanurate

• The case is presented of a man with allergic contact dermatitis and occupational asthma due to triglycidylisocyanurate (TGIC), which is used as a hardener in thermosetting powder paint [1].
• Hypersensitivity pneumonitis caused by triglycidyl isocyanurate [2].
• Occupational contact dermatitis from triglycidyl isocyanurate in a powder paint sprayer [3].

High impact information on alpha-Triglycidyl isocyanurate

• Epoxide hydrolysis metabolites are detected in microsomal incubations, and cyclohexene oxide inhibits teroxirone metabolism, suggesting that epoxide hydrase may be responsible for teroxirone biotransformation [4].
• Teroxirone is metabolized by rat liver, but not lung, microsomal preparations by an NADPH-independent pathway [4].
• Crystallographic resolution and crystal and molecular structures of stereoisomers of 1,3,5-triglycidyl-s-triazinetrione [5].

Chemical compound and disease context of alpha-Triglycidyl isocyanurate

• All 5 workers were found to have allergic contact dermatitis from 2 epoxy resin hardeners, both of which were commercial preparations of triglycidyl isocyanurate (TGIC) [6].

Analytical, diagnostic and therapeutic context of alpha-Triglycidyl isocyanurate

• Teroxirone is an experimental triepoxide antitumor agent currently undergoing evaluation in clinical trials [4].
• A method for the determination of triglycidyl isocyanurate (TGIC) from powder coatings using gas chromatography with mass spectrometric (GC/MS) detection is presented [7].
• Degradation of triglycidyl isocyanurate as a cause of false-negative patch test reaction [8].

References