Disease relevance of Pargeverine

• The results of this study showed that propinox was an effective drug in the treatment of moderate to severe colic pain of biliary origin [1].
• The incidence of mouth dryness was significantly more frequent with the 20 mg and 30 mg doses of propinox than with the placebo or the 10 mg dose [2].

High impact information on Pargeverine

• Propinox in intestinal colic: multicenter randomized prospective double-blind study of three doses of propinox vs. placebo in acute intestinal colic pain [2].
• Antispasmodic action of propinox on the isolated human gallbladder: possible mechanism of action [3].
• For the benzothiacepine binding sites, Ki for propinox was 5.2 x 10(-6) M [3].
• The inhibition constant (Ki) of propinox for muscarinic receptors of guinea pig ileum smooth muscle, which contains a mixed M2-M3 receptor population, was 1.6 x 10(-6) M [3].
• Propinox is an antispasmodic drug frequently used in the treatment of disorders of the gastrointestinal tract, the uterus and the gallbladder, but little is known about its relaxing activity in gallbladder tissue [3].

Analytical, diagnostic and therapeutic context of Pargeverine

• The aim of this double-blind study was to assess the efficacy and tolerability of propinox administered i.v. and to establish a dose-response relationship according to three dose levels (10 mg, 20 mg and 30 mg), vs. placebo in patients with moderate-to-severe acute intestinal colic pain [2].

References