Chemical Compound Review:
CHEMBL49436 N-phenylacridin-9-amine
Synonyms:
AC1L2CQF, LS-14214, ZINC03899979, AKOS002710482, BRN 0210868, ...
- Potential antitumor agents. 36. Quantitative relationships between experimental antitumor activity, toxicity, and structure for the general class of 9-anilinoacridine antitumor agents. Denny, W.A., Cain, B.F., Atwell, G.J., Hansch, C., Panthananickal, A., Leo, A. J. Med. Chem. (1982)
- Inverse correlation between bacterial frameshift mutagenicity and yeast mitochondrial effects of antitumour anilinoacridines. Baguley, B.C., Ferguson, L.R. Chem. Biol. Interact. (1985)
- Relative activity of structural analogues of amsacrine against human leukemia cell lines containing amsacrine-sensitive or -resistant forms of topoisomerase II: use of computer simulations in new drug development. Zwelling, L.A., Mitchell, M.J., Satitpunwaycha, P., Mayes, J., Altschuler, E., Hinds, M., Baguley, B.C. Cancer Res. (1992)
- Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress? Baguley, B.C., Wakelin, L.P., Jacintho, J.D., Kovacic, P. Current medicinal chemistry. (2003)
- Antimalarial 9-anilinoacridine compounds directed at hematin. Auparakkitanon, S., Noonpakdee, W., Ralph, R.K., Denny, W.A., Wilairat, P. Antimicrob. Agents Chemother. (2003)
- DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles. Atwell, G.J., Fan, J.Y., Tan, K., Denny, W.A. J. Med. Chem. (1998)
- Potential antitumor agents. 38. 3-substituted 5-carboxamido derivatives of amsacrine. Denny, W.A., Atwell, G.J., Baguley, B.C. J. Med. Chem. (1983)
- Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity. Bacherikov, V.A., Chou, T.C., Dong, H.J., Zhang, X., Chen, C.H., Lin, Y.W., Tsai, T.J., Lee, R.Z., Liu, L.F., Su, T.L. Bioorg. Med. Chem. (2005)
- Kinetics and mechanism of general acid-catalysed thiolytic cleavage of 9-anilinoacridine. Khan, M.N., Kuliya-Umar, A.F. Bioorg. Med. Chem. (1995)
- DNA adducts of 9-anilinoacridine mustards: characterization by NMR. Fan, J.Y., Ohms, S.J., Boyd, M., Denny, W.A. Chem. Res. Toxicol. (1999)
- Electron donor properties of the antitumour drug amsacrine as studied by fluorescence quenching of DNA-bound ethidium. Davis, L.M., Harvey, J.D., Baguley, B.C. Chem. Biol. Interact. (1987)