Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-J-43495 (2S)-2-[[(2S)-2-[2-[[(2S)-2...

Synonyms: AC1L4MMY, AC1Q5JRE, CTK5B3672, AR-1J2954, 61756-28-3, ...

Turnbull, L.W. et al., Mallet, A.I. et al., Capron, M. et al., Ogawa, H. et al., Goetzl, E.J. et al.

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Disease relevance of Ala-gly-ser-glu

Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A) and histamine, are preferentially chemotactic for eosinophils in vitro [1].

High impact information on Ala-gly-ser-glu

Two eosinophilotactic tetrapeptides of amino acid sequence Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu were recovered from the extracts in 4-12% overall yield of the low molecular weight peak from Sephadex G-25 [2].
At the same concentrations, these peptides (C5a, f met-leu-phe, and ala-gly-ser-glu) induced the following release of glucosaminidase from neutrophils and eosinophils, respectively: 42% and 2%, 42% and 2%, and 29% and 2% [3].
Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu both promoted eosinophil accumulation when applied to the abraded skin of man or i.d. to the marmoset [4].
When Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu were combined in various concentrations the resultant chemotaxis was either negligible or no greater than that produced when each peptide was tested separately [4].
This report is concerned with the development of a gas chromatographic mass spectrometric assay for the two eosinophil chemotactic peptides, Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu, which appear to have a role to play in the course of the inflammatory process in skin disorders [5].

References

Tetrapeptides of the eosinophil chemotactic factor of anaphylaxis (ECF-A) enhance eosinophil Fc receptor. Capron, M., Capron, A., Goetzl, E.J., Austen, K.F. Nature (1981) [Pubmed]
Purification and synthesis of eosinophilotactic tetrapeptides of human lung tissue: identification as eosinophil chemotactic factor of anaphylaxis. Goetzl, E.J., Austen, K.F. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
Comparative study of eosinophil and neutrophil chemotaxis and enzyme release. Ogawa, H., Kunkel, S.L., Fantone, J.C., Ward, P.A. Am. J. Pathol. (1981) [Pubmed]
Human eosinophils, acidic tetrapeptides (ECF-A) and histamine. Interactions in vitro and in vivo. Turnbull, L.W., Evans, D.P., Kay, A.B. Immunology (1977) [Pubmed]
Development of a gas chromatography mass spectrometry assay for the two eosinophil chemotactic factors of anaphylaxis. Mallet, A.I., Rose, K., Priddle, J.D. Biomed. Mass Spectrom. (1983) [Pubmed]

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