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Chemical Compound Review

Sephadex G 25     (2R,3R,4R,5S,6R)-6- (hydroxymethyl)oxane-2...

Synonyms: SureCN8994742, AC1MJ1SX, 9041-35-4
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Disease relevance of Sephadex G 25


High impact information on Sephadex G 25

  • Gel filtration of the extracts of the pancreas and stomach on Sephadex G-25 yielded two immunoreactive peaks, one corresponding in each case to the somatostatin tetradecapeptide [6].
  • To determine whether taxol remained bound to tubulin subunits, we subjected depolymerized taxol-treated microtubule protein to Sephadex G-25 chromatography, and the fractions were assayed for taxol content by reverse-phase HPLC [7].
  • Because insulin-stimulated CKII activity was maintained after chromatography of cell extracts on Sephadex G-25, it is unlikely that the effect is mediated by a low-molecular-weight activator of the kinase [8].
  • The difference in MAP-2 kinase activity in extract supernatants from control and insulin-treated cells is also preserved after rapid chromatography on Sephadex G-25 [9].
  • "Transfer factor" was prepared by Sephadex G-25 chromatography of lymph node cell lysates from guinea pigs immunized with ovalbumin or bovine gamma globulin [10].

Chemical compound and disease context of Sephadex G 25


Biological context of Sephadex G 25


Anatomical context of Sephadex G 25

  • These activated lectins were purified on a Sephadex G-25 column and showed the binding affinity to an affinity column, glucosylated Sepharose, and to the human erythrocyte ghost membrane [21].
  • Previous studies from other laboratories, using rabbit reticulocyte lysate filtered through Sephadex G-25 or G-50, have demonstrated that glucose 6-phosphate is required to maintain active rates of translation, but its mechanism of action is currently unsettled [22].
  • A transfer factor-like activity was prepared by Sephadex G-25 chromatography of immune guinea pig leukocyte lysates [23].
  • The phospholipid mediator 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (AGEPC) increases human polymorphonuclear leukocyte (PMN) adherence to Sephadex G-25 in manner directly proportional to the concentration of AGEPC from 2 to 650 nM [24].
  • Human serum, or serum proteins excluded by Sephadex G-25, irreversibly inhibited the ability of mouse pancreatic islet cells to accumulate Rb+ [25].

Associations of Sephadex G 25 with other chemical compounds


Gene context of Sephadex G 25


Analytical, diagnostic and therapeutic context of Sephadex G 25


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