Gene Review:
CCL11 - chemokine (C-C motif) ligand 11
Homo sapiens
Synonyms:
C-C motif chemokine 11, Eosinophil chemotactic protein, Eotaxin, MGC22554, SCYA11, ...
Torii,
Morokata,
Denburg,
Salcedo,
Kaneko,
Van Steen,
Young,
Millner,
Taguchi,
Sten,
Watson,
Pease,
Weiss,
Culley,
Ying,
Glue,
Kimmig,
Raby,
Robinson,
Foley,
Jacobi,
Skov,
Malling,
Cheng,
Jarman,
Yamada,
Jose,
Williams,
Lindpaintner,
Cook,
Lee,
Lazarus,
Anting,
Shimizu,
Ryder,
Höchstetter,
Takahashi,
O'Byrne,
Erlich,
Sehmi,
Murphy,
Masunaga,
Takizawa,
Oppenheim,
Yamamoto,
Celedón,
Kleinman,
Dorman,
Poulsen,
Silverman,
Baatjes,
Ward,
Ponce,
Kapp,
Fadlon,
Sato,
Hviid,
Zee,
Jing,
Kay,
Fujii,
Suzuki,
Kirchem,
Elsner,
Ridker,
Lamberth,
Morihira,
Jinquan,
- CCR3 expression induced by IL-2 and IL-4 functioning as a death receptor for B cells. Jinquan, T., Jacobi, H.H., Jing, C., Millner, A., Sten, E., Hviid, L., Anting, L., Ryder, L.P., Glue, C., Skov, P.S., Jarman, E., Lamberth, K., Malling, H.J., Poulsen, L.K. J. Immunol. (2003)
- TLR3-Mediated Synthesis and Release of Eotaxin-1/CCL11 from Human Bronchial Smooth Muscle Cells Stimulated with Double-Stranded RNA. Niimi, K., Asano, K., Shiraishi, Y., Nakajima, T., Wakaki, M., Kagyo, J., Takihara, T., Suzuki, Y., Fukunaga, K., Shiomi, T., Oguma, T., Sayama, K., Yamaguchi, K., Natori, Y., Matsumoto, M., Seya, T., Yamaya, M., Ishizaka, A. J. Immunol. (2007)
- Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction. Zee, R.Y., Cook, N.R., Cheng, S., Erlich, H.A., Lindpaintner, K., Lee, R.T., Ridker, P.M. Atherosclerosis (2004)
- Characterisation of the biological activity of recombinant equine eotaxin in vitro. Benarafa, C., Collins, M.E., Hamblin, A.S., Sabroe, I., Cunningham, F.M. Cytokine (2002)
- Concentration of CCL11, CXCL8 and TNF-alpha in sputum and plasma of patients undergoing asthma or chronic obstructive pulmonary disease exacerbation. Daldegan, M.B., Teixeira, M.M., Talvani, A. Braz. J. Med. Biol. Res. (2005)
- Role of eotaxin-1 signaling in ovarian cancer. Levina, V., Nolen, B.M., Marrangoni, A.M., Cheng, P., Marks, J.R., Szczepanski, M.J., Szajnik, M.E., Gorelik, E., Lokshin, A.E. Clin. Cancer Res. (2009)
- The eosinophil. Rothenberg, M.E., Hogan, S.P. Annu. Rev. Immunol. (2006)
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P.D., Wu, L., Mackay, C.R., LaRosa, G., Newman, W., Gerard, N., Gerard, C., Sodroski, J. Cell (1996)
- Morphologic and functional evidence for release of mast-cell products in bullous pemphigoid. Wintroub, B.U., Mihm, M.C., Goetzl, E.J., Soter, N.A., Austen, K.F. N. Engl. J. Med. (1978)
- Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. Soter, N.A., Wasserman, S.I., Austen, K.F. N. Engl. J. Med. (1976)
- Human eotaxin represents a potent activator of the respiratory burst of human eosinophils. Elsner, J., Höchstetter, R., Kimmig, D., Kapp, A. Eur. J. Immunol. (1996)
- Characterization of chemokine CCR3 agonist-mediated eosinophil recruitment in the Brown-Norway rat. Kudlacz, E.M., Whitney, C.A., Andresen, C.J., Umland, J.P., Cheng, J.B. Br. J. Pharmacol. (1999)
- Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Huaux, F., Gharaee-Kermani, M., Liu, T., Morel, V., McGarry, B., Ullenbruch, M., Kunkel, S.L., Wang, J., Xing, Z., Phan, S.H. Am. J. Pathol. (2005)
- Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils. Stubbs, V.E., Schratl, P., Hartnell, A., Williams, T.J., Peskar, B.A., Heinemann, A., Sabroe, I. J. Biol. Chem. (2002)
- Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation. Sehmi, R., Dorman, S., Baatjes, A., Watson, R., Foley, R., Ying, S., Robinson, D.S., Kay, A.B., O'Byrne, P.M., Denburg, J.A. Immunology (2003)
- Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells. Salcedo, R., Young, H.A., Ponce, M.L., Ward, J.M., Kleinman, H.K., Murphy, W.J., Oppenheim, J.J. J. Immunol. (2001)
- Functional analysis of the chemokine receptor CCR3 on airway epithelial cells. Beck, L.A., Tancowny, B., Brummet, M.E., Asaki, S.Y., Curry, S.L., Penno, M.B., Foster, M., Bahl, A., Stellato, C. J. Immunol. (2006)
- IL-17A Induces Eotaxin-1/CC Chemokine Ligand 11 Expression in Human Airway Smooth Muscle Cells: Role of MAPK (Erk1/2, JNK, and p38) Pathways. Rahman, M.S., Yamasaki, A., Yang, J., Shan, L., Halayko, A.J., Gounni, A.S. J. Immunol. (2006)
- Eotaxin polymorphisms and serum total IgE levels in children with asthma. Raby, B.A., Van Steen, K., Lazarus, R., Celedón, J.C., Silverman, E.K., Weiss, S.T. J. Allergy Clin. Immunol. (2006)
- Heterodimerization of CCR2 chemokines and regulation by glycosaminoglycan binding. Crown, S.E., Yu, Y., Sweeney, M.D., Leary, J.A., Handel, T.M. J. Biol. Chem. (2006)
- Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines. Culley, F.J., Fadlon, E.J., Kirchem, A., Williams, T.J., Jose, P.J., Pease, J.E. Eur. J. Immunol. (2003)
- Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Ogilvie, P., Bardi, G., Clark-Lewis, I., Baggiolini, M., Uguccioni, M. Blood (2001)
- Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. White, J.R., Imburgia, C., Dul, E., Appelbaum, E., O'Donnell, K., O'Shannessy, D.J., Brawner, M., Fornwald, J., Adamou, J., Elshourbagy, N.A., Kaiser, K., Foley, J.J., Schmidt, D.B., Johanson, K., Macphee, C., Moores, K., McNulty, D., Scott, G.F., Schleimer, R.P., Sarau, H.M. J. Leukoc. Biol. (1997)
- Differential regulation of eotaxin expression by IFN-gamma in airway epithelial cells. Matsukura, S., Kokubu, F., Kuga, H., Kawaguchi, M., Ieki, K., Odaka, M., Suzuki, S., Watanabe, S., Takeuchi, H., Adachi, M., Stellato, C., Schleimer, R.P. J. Allergy Clin. Immunol. (2003)
- Backbone dynamics of the human CC chemokine eotaxin: fast motions, slow motions, and implications for receptor binding. Crump, M.P., Spyracopoulos, L., Lavigne, P., Kim, K.S., Clark-lewis, I., Sykes, B.D. Protein Sci. (1999)
- Eotaxin induces a sustained reduction in the functional adhesive state of very late antigen 4 for the connecting segment 1 region of fibronectin. Sung, K.P., Yang, L., Kim, J., Ko, D., Stachnick, G., Castaneda, D., Nayar, J., Broide, D.H. J. Allergy Clin. Immunol. (2000)
- CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3. Struyf, S., Proost, P., Schols, D., De Clercq, E., Opdenakker, G., Lenaerts, J.P., Detheux, M., Parmentier, M., De Meester, I., Scharpé, S., Van Damme, J. J. Immunol. (1999)
- Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Kampen, G.T., Stafford, S., Adachi, T., Jinquan, T., Quan, S., Grant, J.A., Skov, P.S., Poulsen, L.K., Alam, R. Blood (2000)
- Cloning, expression, and characterization of the human eosinophil eotaxin receptor. Daugherty, B.L., Siciliano, S.J., DeMartino, J.A., Malkowitz, L., Sirotina, A., Springer, M.S. J. Exp. Med. (1996)
- Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. Uguccioni, M., Loetscher, P., Forssmann, U., Dewald, B., Li, H., Lima, S.H., Li, Y., Kreider, B., Garotta, G., Thelen, M., Baggiolini, M. J. Exp. Med. (1996)
- Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. Forssmann, U., Uguccioni, M., Loetscher, P., Dahinden, C.A., Langen, H., Thelen, M., Baggiolini, M. J. Exp. Med. (1997)
- Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma. Kleinhans, M., Tun-Kyi, A., Gilliet, M., Kadin, M.E., Dummer, R., Burg, G., Nestle, F.O. Blood (2003)
- A novel, selective, and orally available antagonist for CC chemokine receptor 3. Morokata, T., Suzuki, K., Masunaga, Y., Taguchi, K., Morihira, K., Sato, I., Fujii, M., Takizawa, S., Torii, Y., Yamamoto, N., Kaneko, M., Yamada, T., Takahashi, K., Shimizu, Y. J. Pharmacol. Exp. Ther. (2006)
- Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. Ponath, P.D., Qin, S., Post, T.W., Wang, J., Wu, L., Gerard, N.P., Newman, W., Gerard, C., Mackay, C.R. J. Exp. Med. (1996)