The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CCL11  -  chemokine (C-C motif) ligand 11

Homo sapiens

Synonyms: C-C motif chemokine 11, Eosinophil chemotactic protein, Eotaxin, MGC22554, SCYA11, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CCL11


High impact information on CCL11

  • The molecular steps involved in eosinophil development and trafficking are described, with special attention to the important role of the transcription factor GATA-1, the eosinophil-selective cytokine IL-5, and the eotaxin subfamily of chemokines [7].
  • CCR3 facilitated infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibited infection by these isolates [8].
  • In addition, a factor chemotactic for human eosinophils with the size and charge characteristics of the eosinophil chemotactic factor of anaphylaxis was identified in blullous fluid [9].
  • Blood specimens were obtained from each arm serially over a one-hour interval, and serum speciments were assessed for histamine, eosinophil chemotactic factor of anaphylaxis, and complement components [10].
  • This initial observation of release of eosinophil chemotactic factor of anaphylaxis in vivo along with histamine assigns the mast cell a central role in cold urticaria [10].

Chemical compound and disease context of CCL11


Biological context of CCL11


Anatomical context of CCL11

  • Because the rat aortic sprouting assay, which is not infiltrated by eosinophils, yielded a positive response to CCL11, this angiogenic response appears to be direct and is not mediated by eosinophil products [16].
  • The angiogenic response induced by CCL11 was about one-half of that induced by basic fibroblast factor, and it was accompanied by an inflammatory infiltrate, which consisted predominantly of eosinophils [16].
  • TLR3-Mediated Synthesis and Release of Eotaxin-1/CCL11 from Human Bronchial Smooth Muscle Cells Stimulated with Double-Stranded RNA [2].
  • The chemotactic activity was consistent with the expression of CCR3, the receptor for CCL11, on human microvascular endothelial cells and was inhibited by mAbs to either human CCL11 or human CCR3 [16].
  • CCL11 also induced the formation of blood vessels in vivo as assessed by the chick chorioallantoic membrane and Matrigel plug assays [16].

Associations of CCL11 with chemical compounds


Physical interactions of CCL11

  • This study shows that eotaxin also interacts with CCR2 and CCR5 and can, thus, affect the responses of monocytes, which express both receptors [22].
  • 125I-Eotaxin-2 binds with high affinity to eosinophils and both eotaxin and cold eotaxin-2 displace the ligand with equal affinity [23].
  • IFN-gamma did not influence the TNF-alpha-induced binding of nuclear factor kappaB to a DNA probe derived from the eotaxin promoter [24].
  • Eotaxin binds the CC chemokine receptor CCR3 that is highly expressed by eosinophils, and it is considered important in the pathology of chronic respiratory disorders such as asthma [25].
  • Eotaxin induces a sustained reduction in the functional adhesive state of very late antigen 4 for the connecting segment 1 region of fibronectin [26].

Enzymatic interactions of CCL11

  • In this study we demonstrate that eotaxin is efficiently cleaved by CD26/DPP IV and that the NH2-terminal truncation affects its biological activity [27].

Regulatory relationships of CCL11


Other interactions of CCL11

  • Although there is a mounting body of evidence that eosinophils are recruited to sites of allergic inflammation by a number of beta-chemokines, particularly eotaxin and RANTES, the receptor that mediates these actions has not been identified [29].
  • It shares receptors with eotaxin and shows full cross-desensitization with this cosinophil-selective chemokine [30].
  • In all assays, eotaxin-2 had the same efficacy as eotaxin, but was somewhat less potent [31].
  • MCP-4 shares the pyroglutamic acidproline NH2-terminal motif and 56-61% sequence identity with the three known monocyte chemotactic proteins and is 60% identical to eotaxin [30].
  • It has marked functional similarities to MCP-3 and eotaxin [30].

Analytical, diagnostic and therapeutic context of CCL11


  1. CCR3 expression induced by IL-2 and IL-4 functioning as a death receptor for B cells. Jinquan, T., Jacobi, H.H., Jing, C., Millner, A., Sten, E., Hviid, L., Anting, L., Ryder, L.P., Glue, C., Skov, P.S., Jarman, E., Lamberth, K., Malling, H.J., Poulsen, L.K. J. Immunol. (2003) [Pubmed]
  2. TLR3-Mediated Synthesis and Release of Eotaxin-1/CCL11 from Human Bronchial Smooth Muscle Cells Stimulated with Double-Stranded RNA. Niimi, K., Asano, K., Shiraishi, Y., Nakajima, T., Wakaki, M., Kagyo, J., Takihara, T., Suzuki, Y., Fukunaga, K., Shiomi, T., Oguma, T., Sayama, K., Yamaguchi, K., Natori, Y., Matsumoto, M., Seya, T., Yamaya, M., Ishizaka, A. J. Immunol. (2007) [Pubmed]
  3. Threonine for alanine substitution in the eotaxin (CCL11) gene and the risk of incident myocardial infarction. Zee, R.Y., Cook, N.R., Cheng, S., Erlich, H.A., Lindpaintner, K., Lee, R.T., Ridker, P.M. Atherosclerosis (2004) [Pubmed]
  4. Characterisation of the biological activity of recombinant equine eotaxin in vitro. Benarafa, C., Collins, M.E., Hamblin, A.S., Sabroe, I., Cunningham, F.M. Cytokine (2002) [Pubmed]
  5. Concentration of CCL11, CXCL8 and TNF-alpha in sputum and plasma of patients undergoing asthma or chronic obstructive pulmonary disease exacerbation. Daldegan, M.B., Teixeira, M.M., Talvani, A. Braz. J. Med. Biol. Res. (2005) [Pubmed]
  6. Role of eotaxin-1 signaling in ovarian cancer. Levina, V., Nolen, B.M., Marrangoni, A.M., Cheng, P., Marks, J.R., Szczepanski, M.J., Szajnik, M.E., Gorelik, E., Lokshin, A.E. Clin. Cancer Res. (2009) [Pubmed]
  7. The eosinophil. Rothenberg, M.E., Hogan, S.P. Annu. Rev. Immunol. (2006) [Pubmed]
  8. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P.D., Wu, L., Mackay, C.R., LaRosa, G., Newman, W., Gerard, N., Gerard, C., Sodroski, J. Cell (1996) [Pubmed]
  9. Morphologic and functional evidence for release of mast-cell products in bullous pemphigoid. Wintroub, B.U., Mihm, M.C., Goetzl, E.J., Soter, N.A., Austen, K.F. N. Engl. J. Med. (1978) [Pubmed]
  10. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. Soter, N.A., Wasserman, S.I., Austen, K.F. N. Engl. J. Med. (1976) [Pubmed]
  11. Human eotaxin represents a potent activator of the respiratory burst of human eosinophils. Elsner, J., Höchstetter, R., Kimmig, D., Kapp, A. Eur. J. Immunol. (1996) [Pubmed]
  12. Characterization of chemokine CCR3 agonist-mediated eosinophil recruitment in the Brown-Norway rat. Kudlacz, E.M., Whitney, C.A., Andresen, C.J., Umland, J.P., Cheng, J.B. Br. J. Pharmacol. (1999) [Pubmed]
  13. Role of Eotaxin-1 (CCL11) and CC chemokine receptor 3 (CCR3) in bleomycin-induced lung injury and fibrosis. Huaux, F., Gharaee-Kermani, M., Liu, T., Morel, V., McGarry, B., Ullenbruch, M., Kunkel, S.L., Wang, J., Xing, Z., Phan, S.H. Am. J. Pathol. (2005) [Pubmed]
  14. Indomethacin causes prostaglandin D(2)-like and eotaxin-like selective responses in eosinophils and basophils. Stubbs, V.E., Schratl, P., Hartnell, A., Williams, T.J., Peskar, B.A., Heinemann, A., Sabroe, I. J. Biol. Chem. (2002) [Pubmed]
  15. Allergen-induced fluctuation in CC chemokine receptor 3 expression on bone marrow CD34+ cells from asthmatic subjects: significance for mobilization of haemopoietic progenitor cells in allergic inflammation. Sehmi, R., Dorman, S., Baatjes, A., Watson, R., Foley, R., Ying, S., Robinson, D.S., Kay, A.B., O'Byrne, P.M., Denburg, J.A. Immunology (2003) [Pubmed]
  16. Eotaxin (CCL11) induces in vivo angiogenic responses by human CCR3+ endothelial cells. Salcedo, R., Young, H.A., Ponce, M.L., Ward, J.M., Kleinman, H.K., Murphy, W.J., Oppenheim, J.J. J. Immunol. (2001) [Pubmed]
  17. Functional analysis of the chemokine receptor CCR3 on airway epithelial cells. Beck, L.A., Tancowny, B., Brummet, M.E., Asaki, S.Y., Curry, S.L., Penno, M.B., Foster, M., Bahl, A., Stellato, C. J. Immunol. (2006) [Pubmed]
  18. IL-17A Induces Eotaxin-1/CC Chemokine Ligand 11 Expression in Human Airway Smooth Muscle Cells: Role of MAPK (Erk1/2, JNK, and p38) Pathways. Rahman, M.S., Yamasaki, A., Yang, J., Shan, L., Halayko, A.J., Gounni, A.S. J. Immunol. (2006) [Pubmed]
  19. Eotaxin polymorphisms and serum total IgE levels in children with asthma. Raby, B.A., Van Steen, K., Lazarus, R., Celedón, J.C., Silverman, E.K., Weiss, S.T. J. Allergy Clin. Immunol. (2006) [Pubmed]
  20. Heterodimerization of CCR2 chemokines and regulation by glycosaminoglycan binding. Crown, S.E., Yu, Y., Sweeney, M.D., Leary, J.A., Handel, T.M. J. Biol. Chem. (2006) [Pubmed]
  21. Proteoglycans are potent modulators of the biological responses of eosinophils to chemokines. Culley, F.J., Fadlon, E.J., Kirchem, A., Williams, T.J., Jose, P.J., Pease, J.E. Eur. J. Immunol. (2003) [Pubmed]
  22. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Ogilvie, P., Bardi, G., Clark-Lewis, I., Baggiolini, M., Uguccioni, M. Blood (2001) [Pubmed]
  23. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. White, J.R., Imburgia, C., Dul, E., Appelbaum, E., O'Donnell, K., O'Shannessy, D.J., Brawner, M., Fornwald, J., Adamou, J., Elshourbagy, N.A., Kaiser, K., Foley, J.J., Schmidt, D.B., Johanson, K., Macphee, C., Moores, K., McNulty, D., Scott, G.F., Schleimer, R.P., Sarau, H.M. J. Leukoc. Biol. (1997) [Pubmed]
  24. Differential regulation of eotaxin expression by IFN-gamma in airway epithelial cells. Matsukura, S., Kokubu, F., Kuga, H., Kawaguchi, M., Ieki, K., Odaka, M., Suzuki, S., Watanabe, S., Takeuchi, H., Adachi, M., Stellato, C., Schleimer, R.P. J. Allergy Clin. Immunol. (2003) [Pubmed]
  25. Backbone dynamics of the human CC chemokine eotaxin: fast motions, slow motions, and implications for receptor binding. Crump, M.P., Spyracopoulos, L., Lavigne, P., Kim, K.S., Clark-lewis, I., Sykes, B.D. Protein Sci. (1999) [Pubmed]
  26. Eotaxin induces a sustained reduction in the functional adhesive state of very late antigen 4 for the connecting segment 1 region of fibronectin. Sung, K.P., Yang, L., Kim, J., Ko, D., Stachnick, G., Castaneda, D., Nayar, J., Broide, D.H. J. Allergy Clin. Immunol. (2000) [Pubmed]
  27. CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3. Struyf, S., Proost, P., Schols, D., De Clercq, E., Opdenakker, G., Lenaerts, J.P., Detheux, M., Parmentier, M., De Meester, I., Scharpé, S., Van Damme, J. J. Immunol. (1999) [Pubmed]
  28. Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Kampen, G.T., Stafford, S., Adachi, T., Jinquan, T., Quan, S., Grant, J.A., Skov, P.S., Poulsen, L.K., Alam, R. Blood (2000) [Pubmed]
  29. Cloning, expression, and characterization of the human eosinophil eotaxin receptor. Daugherty, B.L., Siciliano, S.J., DeMartino, J.A., Malkowitz, L., Sirotina, A., Springer, M.S. J. Exp. Med. (1996) [Pubmed]
  30. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. Uguccioni, M., Loetscher, P., Forssmann, U., Dewald, B., Li, H., Lima, S.H., Li, Y., Kreider, B., Garotta, G., Thelen, M., Baggiolini, M. J. Exp. Med. (1996) [Pubmed]
  31. Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. Forssmann, U., Uguccioni, M., Loetscher, P., Dahinden, C.A., Langen, H., Thelen, M., Baggiolini, M. J. Exp. Med. (1997) [Pubmed]
  32. Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma. Kleinhans, M., Tun-Kyi, A., Gilliet, M., Kadin, M.E., Dummer, R., Burg, G., Nestle, F.O. Blood (2003) [Pubmed]
  33. A novel, selective, and orally available antagonist for CC chemokine receptor 3. Morokata, T., Suzuki, K., Masunaga, Y., Taguchi, K., Morihira, K., Sato, I., Fujii, M., Takizawa, S., Torii, Y., Yamamoto, N., Kaneko, M., Yamada, T., Takahashi, K., Shimizu, Y. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  34. Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils. Ponath, P.D., Qin, S., Post, T.W., Wang, J., Wu, L., Gerard, N.P., Newman, W., Gerard, C., Mackay, C.R. J. Exp. Med. (1996) [Pubmed]
WikiGenes - Universities