Disease relevance of Clidinum

• To determine the effect of a standard meal on colonic myoelectrical and motor activity in the irritable-bowel syndrome and to determine the effect of a single dose of an oral anticholinergic drug (clidinium bromide) on this response, we studied 10 patients [1].

High impact information on Clidinum

• The quarternary ammonium antimuscarinic drugs propantheline bromide and clidinium bromide, given orally at the usual therapeutic doses, delayed gastric emptying of a swallowed radiolabeled liquid meal as measured by a gamma camera [2].

Chemical compound and disease context of Clidinum

• Among 169 patients with irritable bowel syndrome (IBS), standard therapy (with clidinium bromide, chlordiazepoxide and isaphaghulla), a compound Ayurvedic preparation (with Aegle marmelos correa plus Bacopa monniere Linn) along with a matching placebo were given in a double blind randomised trial for 6 wk [3].

Analytical, diagnostic and therapeutic context of Clidinum

• The determination of a degradation product in clidinium bromide drug substance by capillary electrophoresis with indirect UV detection [4].
• Results obtained for the analysis of a clidinium bromide drug substance lot using this CE method and a thin layer chromatography method were compared and found to be in agreement [4].
• The addition of clidinium bromide did not appear to affect gastrointestinal transit time [5].

References