Disease relevance of propantheline

• Nine patients with duodenal ulcer were studied after a low dose (15 mg) and after a near toxic dose (averaging 48 mg) of the anticholinergic, propantheline [1].
• Cimetidine plus propantheline for chronic pancreatitis [2].
• Unilateral mydriasis after use of propantheline bromide in an antiperspirant [3].
• The effect of cimetidine and propantheline on the symptoms of a patient with systemic mastocytosis [4].
• In a prospective, double-blind, randomized crossover design 13 normal subjects were given 30 mg propantheline or placebo 90 min before taking a 113m-indium-labeled liquid test meal, the volume of which was adjusted to body weight [5].

High impact information on propantheline

• Effect of low-dose propantheline on food-stimulated gastric acid secretion: comparison with an "optimal effective dose" and interaction with cimetidine [1].
• Also, peripheral venous vasopressin, propantheline bromide, and glucagon were without effect [6].
• Acute administration of propantheline bromide reduced gastric albumin leakage (-50.7%, p less than 0.05) and concurrently decreased width of tight junctions (p less than 0.05) in all patients [7].
• Propantheline significantly reduced the gastric emptying rate, with a decreased gastric emptying coefficient (p = 0.0007) and an increased gastric half emptying time (p = 0.0168) in all subjects, but no change in the lag phase (p = 0.1214) [8].
• Propantheline bromide tablets have been shown to undergo significant hydrolysis at alkaline pH in vitro [9].

Chemical compound and disease context of propantheline

• Oxybutynin versus propantheline in patients with multiple sclerosis and detrusor hyperreflexia [10].
• Little toxicity was seen at the low dose level with ampicillin, penicillin VK, 8-methoxypsoralen or propantheline bromide [11].
• Penthienate was significantly better than propantheline in improving cystometric capacity (P = 0.03), and reducing the amplitude of unstable detrusor contractions (P = 0.01), and was perceived as more effective by patients for frequency, nocturia and incontinence [12].
• CASE SUMMARIES: Case 1: A 27-year-old quadriplegic man with an American Spinal Injury Association (ASIA) Frankel class C injury to C5/C6 experienced profuse sweating and requested propantheline [13].
• METHODS: A multicenter, double-blind, randomized trial comparing ranitidine (150 mg) plus propantheline bromide 15 mg at bedtime to ranitidine 300 mg alone at bedtime was conducted in 161 patients with endoscopically confirmed uncomplicated duodenal ulcer [14].

Biological context of propantheline

• By contrast, both doses of propantheline increased heart rate and reduced salivary volume significantly (P less than 0.05) [15].
• Oxybutynin has statistically significant effects on subjective symptoms and objective urodynamic parameters in patients with detrusor hyperactivity compared to propantheline [16].
• Unlike atropine, propantheline and methylscopolamine, pirenzepine is effective in preventing gastric erosions at doses much lower than those that affect pupillary reflex [17].
• Food reduces the oral bioavailability of propantheline bromide in healthy subjects [18].
• The only significant differences in AUC were seen when comparing tablets alone versus tablets with cholestyramine (P less than .0005) and tablets with propantheline (P less than .01) [19].

Anatomical context of propantheline

• To test this hypothesis, we compared the response of the lower esophageal sphincter (LES) and esophageal peristaltic contractions to bethanechol in 12 healthy controls after background oral doses of placebo, pirenzepine (50 mg), and propantheline (30 mg) [20].
• Propantheline may reduce the salivary excretion of etoposide and could reduce its toxic effects on the mucosa [21].
• Further, we determined whether treatment with muscarinic drugs that either increase (e.g., pilocarpine) or decrease (e.g., propantheline) saliva secretion affects the submandibular gland taurine content [22].
• Propantheline was also a substrate for P-glycoprotein-mediated secretory transport, but in contrast to verapamil, propantheline secretory transport was expressed in rat ileum [23].
• Therefore, it is suggested that the transport of propantheline across the brush border membrane consists of at least two processes [24].

Associations of propantheline with other chemical compounds

• Clidinium bromide, 5 mg, delayed gastric emptying to the same extent as 15 mg propantheline bromide without the marked suppression of salivary secretion induced by the latter [25].
• Its rate of oral absorption is predominantly dependent on the rate of gastric emptying, being delayed by food, propantheline, pethidine and diamorphine and enhanced by metoclopramide [26].
• Mean grade of improvement (visual analogue scale) was significantly higher with oxybutynin (58.2%) versus propantheline (44.7%) and placebo (43.4%) [16].
• CONCLUSIONS: In an oral lactose tolerance test, delaying gastric emptying with propantheline improved tolerance in lactose maldigesters, as measured by diminished gastrointestinal symptoms and reduced breath hydrogen concentration [27].
• Each patient underwent urodynamic evaluation before and after the parenteral administration of propantheline bromide [28].

Gene context of propantheline

• Enhancement of gastrin release by propantheline was not due to its antisecretory effect since intragastric pH after the meal was held constant at 5.0 by intragastric titration in vivo [15].
• Cystometric response to propantheline in detrusor hyperreflexia: therapeutic implications [28].
• Cortisol and prolactin levels were not changed 12, 16 and 20 hr after propantheline (30 mg) nor 12 hr after propantheline (45 mg) [29].
• We investigated the intestinal transport of verapamil, chlorpromazine, and propantheline, particularly their P-glycoprotein-mediated secretion [23].
• Indications include incontinence despite pharmacologic manipulation, persistent hydroureteronephrosis, vesicoureteral reflux, and propantheline bromide intolerance [30].

Analytical, diagnostic and therapeutic context of propantheline

• Gastric mucosal damage in rats induced by lateral hypothalamic lesions: protection by propantheline, cimetidine, and vagotomy [31].
• Effects of orally-administered pirenzepine and propantheline bromide on food-stimulated gastric acid secretion, serum gastrin concentration, salivary flow and heart rate were compared in 10 duodenal ulcer patients in a placebo-controlled, double-blind study [15].
• Analysis of propantheline bromide in serum by high-performance liquid chromatography [32].
• Propantheline as an adjuvant to weight loss after vertical gastroplasty [33].
• We designed a phase II trial of propantheline in patients receiving high-dose ICE (ifosfamide 20 mg/m2, carboplatin 1.8 g/m2, etoposide 3 g/m2 in divided doses over 6 days) chemotherapy plus autologous hematopoietic stem cell support [34].

References