Disease relevance of Aegle

• Similar to the Aegle marmelos extracts, lupeol was found to stimulate the decoy effect of RA4 DNA sequence, increasing at a high level ERa gene expression in MDA-MB-231 ERalpha-negative breast cancer cells, and also inhibited cell proliferation [1].
• INTRODUCTION: We demonstrate the effect of Aegle marmelos leaf extract (AMLEt) and alpha-tocopherol on plasma lipids, lipid peroxides and marker enzymes in rats with isoproterenol (ISO)-induced myocardial infarction [2].
• The anticancer effect of hydroalcoholic extract of Aegle marmelos (AME) was studied in the Ehrlich ascites carcinoma bearing Swiss albino mice [3].

High impact information on Aegle

• The effect of hydroalcoholic (80% ethanol, 20% water) extract of leaves of Aegle marmelos was examined on carcinogen-metabolizing phase-I and phase-II enzymes, antioxidant enzymes, glutathione content, lactate dehydrogenase and lipid peroxidation, using two doses of dried extract (50 and 100 mg kg(-1) daily for 14 days), in the liver of mice [4].
• A study of hypoglycemic and antioxidant activity of Aegle marmelos in alloxan induced diabetic rats [5].
• Marmenol: a 7-geranyloxycoumarin from the leaves of Aegle marmelos Corr [6].
• Hypoglycaemic effect of water extracts of Aegle marmelos fruits in streptozotocin diabetic rats [7].
• In an effort to test the hypoglycemic activity of Aegle marmelos and Hibiscus rosa sinensis in glucose induced hyperglycemic rats, their alcoholic leaf extracts were studied [8].

Biological context of Aegle

• Oxidative stress produced by alloxan was found to be significantly lowered by the administration of Aegle marmelos extract [9].

Associations of Aegle with chemical compounds

• Kinetic studies of purified malate dehydrogenase in liver of streptozotocin-diabetic rats and the effect of leaf extract of Aegle marmelose (L.) Correa ex Roxb [10].
• Sixteen patients received dried unripe fruit powder of 'bel' (Aegle marmelos), 19 received dried powdered plant of 'thankuni' (Hydrocotyle asiatica), 15 received a similar preparation of 'gandhavadulia' (Paederia foetida), 15 received ampicillin and 17 received a placebo [11].
• All twelve fungi were inhibited by seven oils (aegle, citronella, geranium, lemongrass, orange, palmarosa and patchouli) [12].

References