Disease relevance of allysine

• The major outer membrane proteins from Escherichia coli K-12 are modified to contain alpha-aminoadipic acid delta-semialdehyde (allysine) [1].

Psychiatry related information on allysine

• A time study indicated that allysine levels increased primarily after the bulk of Schiff base synthesis [2].

High impact information on allysine

• It was subsequently shown that the apparent deficiency in lysyl residues was due, at least in part, to the presence of unusually high levels of allysine , a cross-link precursor formed from peptide-bound lysine under the catalytic action of lysyl oxidase [3].
• The elastin incubated with ammonium chloride showed that DESP and IDP levels increased as the allysine content decreased [4].
• Acid hydrolysis followed by amino acid analysis of envelopes either reduced with NaB[3H]4 or labeled with [14C]lysine and reduced with NaBH4 yielded allysine and two labeled fragments with elution profiles and molecular weights (250 and 330) consistent with Schiff base products derived at least in part from allysine [5].
• Oxidative deamination of the epsilon-amino group of lysyl residues to form allysine is the initial reaction in the cross-linking of collagen and elastin in vertebrates [5].
• Several enzymes of the lysine pathway of Saccharomyces cerevisiae were found to respond to an induction mechanism mediated by the product of gene LYS14 in the presence of 2-aminoadipate semialdehyde, an intermediate of this pathway [6].

Chemical compound and disease context of allysine

• Using PDH from E. coli or P. pastoris, the enzymatic process was scale-up to prepare kg quantity of allysine ethylene acetal 5 [7].

Anatomical context of allysine

• Egg shell membrane protein contains significant quantities of the lysine-derived aldehyde, allysine, and its aldol condensation product [8].

Gene context of allysine

• The leaky auxotrophic behaviour of lys14 mutants is explained by the low basal level of expression of LYS9, the structural gene of this enzyme, in the absence of induction by 2-aminoadipate semialdehyde [6].
• The allysine content in rat aorta elastin dramatically increased from 1 week to 2 weeks of age [9].

References