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Chemical Compound Review

2-AMINOADIPIC ACID     2-aminohexanedioic acid

Synonyms: Aminoadipate, a-Aminoadipate, ARONIS020630, CHEMBL433238, AG-K-70498, ...
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Disease relevance of alpha-Aminoadipic acid


High impact information on alpha-Aminoadipic acid


Chemical compound and disease context of alpha-Aminoadipic acid


Biological context of alpha-Aminoadipic acid


Anatomical context of alpha-Aminoadipic acid


Associations of alpha-Aminoadipic acid with other chemical compounds


Gene context of alpha-Aminoadipic acid


Analytical, diagnostic and therapeutic context of alpha-Aminoadipic acid


  1. alpha-Hydroxyglutarate as an intermediate in the catabolism of alpha-aminoadipate by Pseudomonas putida. Kopchick, J.J., Hartline, R.A. J. Biol. Chem. (1979) [Pubmed]
  2. Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8. Sakai, H., Vassylyeva, M.N., Matsuura, T., Sekine, S., Gotoh, K., Nishiyama, M., Terada, T., Shirouzu, M., Kuramitsu, S., Vassylyev, D.G., Yokoyama, S. J. Mol. Biol. (2003) [Pubmed]
  3. Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes. de La Fuente, J.L., Rumbero, A., Martín, J.F., Liras, P. Biochem. J. (1997) [Pubmed]
  4. Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, alpha aminoadipate. McBean, G.J. Br. J. Pharmacol. (1994) [Pubmed]
  5. Metabonomic investigations into hydrazine toxicity in the rat. Nicholls, A.W., Holmes, E., Lindon, J.C., Shockcor, J.P., Farrant, R.D., Haselden, J.N., Damment, S.J., Waterfield, C.J., Nicholson, J.K. Chem. Res. Toxicol. (2001) [Pubmed]
  6. Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses. Li, H., Xu, H., Graham, D.E., White, R.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Characterization and metabolic function of a peroxisomal sarcosine and pipecolate oxidase from Arabidopsis. Goyer, A., Johnson, T.L., Olsen, L.J., Collakova, E., Shachar-Hill, Y., Rhodes, D., Hanson, A.D. J. Biol. Chem. (2004) [Pubmed]
  8. Domain structure characterization of the multifunctional alpha-aminoadipate reductase from Penicillium chrysogenum by limited proteolysis. Activation of alpha-aminoadipate does not require the peptidyl carrier protein box or the reduction domain. Hijarrubia, M.J., Aparicio, J.F., Martín, J.F. J. Biol. Chem. (2003) [Pubmed]
  9. A nonameric core sequence is required upstream of the LYS genes of Saccharomyces cerevisiae for Lys14p-mediated activation and apparent repression by lysine. Becker, B., Feller, A., el Alami, M., Dubois, E., Piérard, A. Mol. Microbiol. (1998) [Pubmed]
  10. The catabolic function of the alpha-aminoadipic acid pathway in plants is associated with unidirectional activity of lysine-oxoglutarate reductase, but not saccharopine dehydrogenase. Zhu, X., Tang, G., Galili, G. Biochem. J. (2000) [Pubmed]
  11. Lysine catabolism in Streptomyces spp. is primarily through cadaverine: beta-lactam producers also make alpha-aminoadipate. Madduri, K., Stuttard, C., Vining, L.C. J. Bacteriol. (1989) [Pubmed]
  12. Aspartate kinase-independent lysine synthesis in an extremely thermophilic bacterium, Thermus thermophilus: lysine is synthesized via alpha-aminoadipic acid not via diaminopimelic acid. Kobashi, N., Nishiyama, M., Tanokura, M. J. Bacteriol. (1999) [Pubmed]
  13. Protein from chromaffin granules promotes survival of mesencephalic dopaminergic neurons by an EGF-receptor ligand-mediated mechanism. Krieglstein, K., Unsicker, K. J. Neurosci. Res. (1997) [Pubmed]
  14. Growth inhibition by alpha-aminoadipate and reversal of the effect by specific amino acid supplements in Saccharomyces cerevisiae. Winston, M.K., Bhattacharjee, J.K. J. Bacteriol. (1982) [Pubmed]
  15. Functional and evolutionary relationship between arginine biosynthesis and prokaryotic lysine biosynthesis through alpha-aminoadipate. Miyazaki, J., Kobashi, N., Nishiyama, M., Yamane, H. J. Bacteriol. (2001) [Pubmed]
  16. Positive and negative selection LYS5MX gene replacement cassettes for use in Saccharomyces cerevisiae. Ito-Harashima, S., McCusker, J.H. Yeast (2004) [Pubmed]
  17. Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosis. Liebmann, B., Mühleisen, T.W., Müller, M., Hecht, M., Weidner, G., Braun, A., Brock, M., Brakhage, A.A. Arch. Microbiol. (2004) [Pubmed]
  18. Selective ablation of astrocytes by intracerebral injections of alpha-aminoadipate. Khurgel, M., Koo, A.C., Ivy, G.O. Glia (1996) [Pubmed]
  19. Effects of alpha-aminoadipate isomers on the morphology of the isolated chick embryo retina. Casper, D.S., Reif-Lehrer, L. Invest. Ophthalmol. Vis. Sci. (1983) [Pubmed]
  20. A comparison of the effects of isomers of alpha-aminoadipic acid and 2-amino-4-phosphonobutyric acid on the light response of the müller glial cell and the electroretinogram. Zimmerman, R.P., Corfman, T.P. Neuroscience (1984) [Pubmed]
  21. Astrocytic regulation of the recovery of extracellular potassium after seizures in vivo. Xiong, Z.Q., Stringer, J.L. Eur. J. Neurosci. (1999) [Pubmed]
  22. Incorporation of 3H from delta-(L-alpha-amino (4,5-3H)adipyl)-L-cysteinyl-D-(4,4-3H)valine into isopenicillin N. O'Sullivan, J., Bleaney, R.C., Huddleston, J.A., Abraham, E.P. Biochem. J. (1979) [Pubmed]
  23. Isolation and nature of intracellular alpha-aminoadipic acid-containing peptides from Paecilomyces persicinus P-10. Eriquez, L.A., Pisano, M.A. Antimicrob. Agents Chemother. (1979) [Pubmed]
  24. Alpha-ketoadipic aciduria: a description of a new metabolic error in lysine-tryptophan degradation. Wilson, R.W., Wilson, C.M., Gates, S.C., Higgins, J.V. Pediatr. Res. (1975) [Pubmed]
  25. Novel posttranslational activation of the LYS2-encoded alpha-aminoadipate reductase for biosynthesis of lysine and site-directed mutational analysis of conserved amino acid residues in the activation domain of Candida albicans. Guo, S., Evans, S.A., Wilkes, M.B., Bhattacharjee, J.K. J. Bacteriol. (2001) [Pubmed]
  26. Functional characterization of 4'-phosphopantetheinyl transferase genes of bacterial and fungal origin by complementation of Saccharomyces cerevisiae lys5. Mootz, H.D., Schörgendorfer, K., Marahiel, M.A. FEMS Microbiol. Lett. (2002) [Pubmed]
  27. A unique fungal lysine biosynthesis enzyme shares a common ancestor with tricarboxylic acid cycle and leucine biosynthetic enzymes found in diverse organisms. Irvin, S.D., Bhattacharjee, J.K. J. Mol. Evol. (1998) [Pubmed]
  28. Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). Goh, D.L., Patel, A., Thomas, G.H., Salomons, G.S., Schor, D.S., Jakobs, C., Geraghty, M.T. Mol. Genet. Metab. (2002) [Pubmed]
  29. Identification of the alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase gene, the human ortholog of the yeast LYS5 gene. Praphanphoj, V., Sacksteder, K.A., Gould, S.J., Thomas, G.H., Geraghty, M.T. Mol. Genet. Metab. (2001) [Pubmed]
  30. Gliotoxic effects of alpha-aminoadipic acid on monolayer cultures of dissociated postnatal mouse cerebellum. Huck, S., Grass, F., Hatten, M.E. Neuroscience (1984) [Pubmed]
  31. Gamma-vinyl GABA: comparison of neurochemical and anticonvulsant effects in mice. Bernasconi, R., Klein, M., Martin, P., Christen, P., Hafner, T., Portet, C., Schmutz, M. J. Neural Transm. (1988) [Pubmed]
  32. Development of the neonatal rabbit retina in organ culture. 1. Comparison with histogenesis in vivo, and the effect of a gliotoxin (alpha-aminoadipic acid). Germer, A., Kühnel, K., Grosche, J., Friedrich, A., Wolburg, H., Price, J., Reichenbach, A., Mack, A.F. Anat. Embryol. (1997) [Pubmed]
  33. Lysine metabolism in the human and the monkey: demonstration of pipecolic acid formation in the brain and other organs. Chang, Y.F. Neurochem. Res. (1982) [Pubmed]
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