Disease relevance of NOOTKATONE

• Toxicity and behavioral effects of nootkatone and two of its derivatives, 1,10-dihydronootkatone and tetrahydronootkatone, to Coptotermes formosanus Shiraki were investigated on workers from two different colonies by using topical application assays, repellency assays, and sand barrier assays [1].

High impact information on NOOTKATONE

• A sesquiterpene nootkatone has no significant effect on P450 activities investigated except for CYP2A6 and CYP2C19 (K(i) = 0.8 and 0.5 microM, respectively) [2].
• Highly efficient production of nootkatone, the grapefruit aroma from valencene, by biotransformation [3].
• Use of nootkatone as a senescence indicator for Rouge La Toma Cv. grapefruit (Citrus paradisi Macf.) [4].
• We found nootkatone, a sesquiterpene ketone, isolated from vetiver oil is a strong repellent and toxicant to Formosan subterranean termites [5].
• From the extract, an insecticidal compound was isolated by bioassay-guided fractionation and identified as nootkatone (1) by GC, GC-MS, and (1)H and (13)C NMR spectroscopy [6].

Biological context of NOOTKATONE

• Therefore, nootkatone appears to be a good indicator of senescence for Rouge La Toma grapefruit [4].

Gene context of NOOTKATONE

• Sand treated with vetiver oil or nootkatone at 100 microg/g substrate were effective barriers to termites [7].

Analytical, diagnostic and therapeutic context of NOOTKATONE

• Four hours after treatment, nootkatone and valencene-13-ol had repellent concentration (RC)50 values of 0.0458 and 0.0712% (wt:vol), respectively; two additional Alaska yellow cedar compounds, nootkatone 1 --> 10 epoxide and carvacrol had reported RC50 values of 0.0858 and 0.112%, respectively [8].

References