Gene Review:
CYP2A6 - cytochrome P450, family 2, subfamily A,...
Homo sapiens
Synonyms:
1,4-cineole 2-exo-monooxygenase, CPA6, CYP2A, CYP2A3, CYPIIA6, ...
Tyndale,
Sellers,
Hecht,
Hochalter,
Villalta,
Murphy,
Oscarson,
McLellan,
Gullstén,
Agúndez,
Benítez,
Rautio,
Raunio,
Pelkonen,
Ingelman-Sundberg,
Nowell,
Sweeney,
Hammons,
Kadlubar,
Lang,
Sellers,
Kaplan,
Tyndale,
Sellers,
Tyndale,
Fernandes,
Kamataki,
Fujita,
Nakayama,
Yamazaki,
Miyamoto,
Ariyoshi,
Kharasch,
Hankins,
Baxter,
Thummel,
- Baculovirus-mediated expression and characterization of rat CYP2A3 and human CYP2a6: role in metabolic activation of nasal toxicants. Liu, C., Zhuo, X., Gonzalez, F.J., Ding, X. Mol. Pharmacol. (1996)
- Role of human cytochrome P450 (CYP) in the metabolic activation of nitrosamine derivatives: application of genetically engineered Salmonella expressing human CYP. Kamataki, T., Fujita, K., Nakayama, K., Yamazaki, Y., Miyamoto, M., Ariyoshi, N. Drug Metab. Rev. (2002)
- Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa. Chen, Y., Liu, Y.Q., Su, T., Ren, X., Shi, L., Liu, D., Gu, J., Zhang, Q.Y., Ding, X. Biochem. Pharmacol. (2003)
- Interaction of heterogeneous nuclear ribonucleoprotein A1 with cytochrome P450 2A6 mRNA: implications for post-transcriptional regulation of the CYP2A6 gene. Christian, K., Lang, M., Maurel, P., Raffalli-Mathieu, F. Mol. Pharmacol. (2004)
- Cytochrome P450 2A6: a new hepatic autoantigen in patients with chronic hepatitis C virus infection. Dalekos, G.N., Obermayer-Straub, P., Bartels, M., Maeda, T., Kayser, A., Braun, S., Loges, S., Schmidt, E., Gershwin, M.E., Manns, M.P. J. Hepatol. (2003)
- Inhibition of cytochrome P450 2A6 increases nicotine's oral bioavailability and decreases smoking. Sellers, E.M., Kaplan, H.L., Tyndale, R.F. Clin. Pharmacol. Ther. (2000)
- Decreasing smoking behaviour and risk through CYP2A6 inhibition. Sellers, E.M., Tyndale, R.F., Fernandes, L.C. Drug Discov. Today (2003)
- CYP2A6 polymorphisms are associated with nicotine dependence and influence withdrawal symptoms in smoking cessation. Kubota, T., Nakajima-Taniguchi, C., Fukuda, T., Funamoto, M., Maeda, M., Tange, E., Ueki, R., Kawashima, K., Hara, H., Fujio, Y., Azuma, J. Pharmacogenomics J. (2006)
- Metabolism and disposition kinetics of nicotine. Hukkanen, J., Jacob, P., Benowitz, N.L. Pharmacol. Rev. (2005)
- Molecular mimicry of human cytochrome P450 by hepatitis C virus at the level of cytotoxic T cell recognition. Kammer, A.R., van der Burg, S.H., Grabscheid, B., Hunziker, I.P., Kwappenberg, K.M., Reichen, J., Melief, C.J., Cerny, A. J. Exp. Med. (1999)
- Genetic variation of CYP2A6, smoking, and risk of cancer. London, S.J., Idle, J.R., Daly, A.K., Coetzee, G.A. Lancet (1999)
- 2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor. Hecht, S.S., Hochalter, J.B., Villalta, P.W., Murphy, S.E. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. Niemelä, O., Parkkila, S., Juvonen, R.O., Viitala, K., Gelboin, H.V., Pasanen, M. J. Hepatol. (2000)
- CYP2A13-catalysed coumarin metabolism: comparison with CYP2A5 and CYP2A6. von Weymarn, L.B., Murphy, S.E. Xenobiotica (2003)
- Quantitative structure-activity relationship analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme. Rahnasto, M., Raunio, H., Poso, A., Wittekindt, C., Juvonen, R.O. J. Med. Chem. (2005)
- CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk. Nowell, S., Sweeney, C., Hammons, G., Kadlubar, F.F., Lang, N.P. Cancer Epidemiol. Biomarkers Prev. (2002)
- Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior. Tyndale, R.F., Sellers, E.M. Therapeutic drug monitoring. (2002)
- A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Fernandez-Salguero, P., Hoffman, S.M., Cholerton, S., Mohrenweiser, H., Raunio, H., Rautio, A., Pelkonen, O., Huang, J.D., Evans, W.E., Idle, J.R. Am. J. Hum. Genet. (1995)
- Human cytochrome P450 CYP2A13: predominant expression in the respiratory tract and its high efficiency metabolic activation of a tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Su, T., Bao, Z., Zhang, Q.Y., Smith, T.J., Hong, J.Y., Ding, X. Cancer Res. (2000)
- Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells. Tiano, H.F., Wang, R.L., Hosokawa, M., Crespi, C., Tindall, K.R., Langenbach, R. Carcinogenesis (1994)
- Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population. Oscarson, M., McLellan, R.A., Gullstén, H., Yue, Q.Y., Lang, M.A., Bernal, M.L., Sinues, B., Hirvonen, A., Raunio, H., Pelkonen, O., Ingelman-Sundberg, M. FEBS Lett. (1999)
- CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism. Godoy, W., Albano, R.M., Moraes, E.G., Pinho, P.R., Nunes, R.A., Saito, E.H., Higa, C., Filho, I.M., Kruel, C.D., Schirmer, C.C., Gurski, R., Lang, M.A., Pinto, L.F. Carcinogenesis (2002)
- Expression and alternative splicing of the cytochrome P-450 CYP2A7. Ding, S., Lake, B.G., Friedberg, T., Wolf, C.R. Biochem. J. (1995)
- Efficient activation of aflatoxin B1 by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract. He, X.Y., Tang, L., Wang, S.L., Cai, Q.S., Wang, J.S., Hong, J.Y. Int. J. Cancer (2006)
- Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Chang, T.K., Weber, G.F., Crespi, C.L., Waxman, D.J. Cancer Res. (1993)
- Single-dose disulfiram does not inhibit CYP2A6 activity. Kharasch, E.D., Hankins, D.C., Baxter, P.J., Thummel, K.E. Clin. Pharmacol. Ther. (1998)
- Induction of Human CYP2A6 Is Mediated by the Pregnane X Receptor with Peroxisome Proliferator-Activated Receptor-{gamma} Coactivator 1{alpha}. Itoh, M., Nakajima, M., Higashi, E., Yoshida, R., Nagata, K., Yamazoe, Y., Yokoi, T. J. Pharmacol. Exp. Ther. (2006)
- CYP2A13 in Human Respiratory Tissues and Lung Cancers: An Immunohistochemical Study with A New Peptide-Specific Antibody. Zhu, L.R., Thomas, P.E., Lu, G., Reuhl, K.R., Yang, G.Y., Wang, L.D., Wang, S.L., Yang, C.S., He, X.Y., Hong, J.Y. Drug Metab. Dispos. (2006)
- Competitive interactions between cytochromes P450 2A6 and 2E1 for NADPH-cytochrome P450 oxidoreductase in the microsomal membranes produced by a baculovirus expression system. Tan, Y., Patten, C.J., Smith, T., Yang, C.S. Arch. Biochem. Biophys. (1997)
- Inhibition of coumarin 7-hydroxylase activity in human liver microsomes. Draper, A.J., Madan, A., Parkinson, A. Arch. Biochem. Biophys. (1997)
- Biosynthesis of new indigoid inhibitors of protein kinases using recombinant cytochrome P450 2A6. Wu, Z.L., Aryal, P., Lozach, O., Meijer, L., Guengerich, F.P. Chem. Biodivers. (2005)
- In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand. Kirby, G.M., Wolf, C.R., Neal, G.E., Judah, D.J., Henderson, C.J., Srivatanakul, P., Wild, C.P. Carcinogenesis (1993)
- Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method. Chen, G.F., Tang, Y.M., Green, B., Lin, D.X., Guengerich, F.P., Daly, A.K., Caporaso, N.E., Kadlubar, F.F. Pharmacogenetics (1999)
- Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells. Crawford, E.L., Weaver, D.A., DeMuth, J.P., Jackson, C.M., Khuder, S.A., Frampton, M.W., Utell, M.J., Thilly, W.G., Willey, J.C. Carcinogenesis (1998)
- Identification and characterisation of novel polymorphisms in the CYP2A locus: implications for nicotine metabolism. Oscarson, M., McLellan, R.A., Gullstén, H., Agúndez, J.A., Benítez, J., Rautio, A., Raunio, H., Pelkonen, O., Ingelman-Sundberg, M. FEBS Lett. (1999)
- High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans. Camus, A.M., Geneste, O., Honkakoski, P., Béréziat, J.C., Henderson, C.J., Wolf, C.R., Bartsch, H., Lang, M.A. Mol. Carcinog. (1993)
- Comparison of cytochrome P450 2A6 polymorphism frequencies in Caucasians and African-Americans using a new one-step PCR-RFLP genotyping method. Paschke, T., Riefler, M., Schuler-Metz, A., Wolz, L., Scherer, G., McBride, C.M., Bepler, G. Toxicology (2001)