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Chemical Compound Review

Arocyte     (2R)-2-propyloctanoic acid

Synonyms: Cereact, Proglia, Arundic acid, Acido arzndico, ONO-2506, ...
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Disease relevance of Arundic acid


High impact information on Arundic acid

  • Here, we probed the putative causal relationship between enhanced astrocytic activation and exacerbation of brain damage in 4/4-KI mice using arundic acid (ONO-2506, Ono Pharmaceutical Co. Ltd), which is known to oppose astrocytic activation through its inhibitory action on S100B synthesis [1].
  • For this purpose, arundic acid (Ono Pharmaceutical Co., Ltd., Mishima, Osaka, Japan), which is known to negatively regulate astrocyte synthesis of S100B, was orally administered to Tg APP(sw) mice for 6 months from 12 months of age, and the effects of the agent on the above parameters were examined [2].
  • The present study showed that the arundic acid had a protective effect against MPTP-induced neuronal damage in the striatum and substantia nigra of mice [4].
  • Pharmacokinetics of arundic Acid, an astrocyte modulating agent, in acute ischemic stroke [3].
  • Arundic acid is an astrocyte modulating agent that improves neurological outcome in experimental acute stroke models [3].

Chemical compound and disease context of Arundic acid


Gene context of Arundic acid


Analytical, diagnostic and therapeutic context of Arundic acid


  1. Modulation of astrocytic activation by arundic acid (ONO-2506) mitigates detrimental effects of the apolipoprotein E4 isoform after permanent focal ischemia in apolipoprotein E knock-in mice. Mori, T., Town, T., Tan, J., Tateishi, N., Asano, T. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  2. Arundic Acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice. Mori, T., Town, T., Tan, J., Yada, N., Horikoshi, Y., Yamamoto, J., Shimoda, T., Kamanaka, Y., Tateishi, N., Asano, T. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  3. Pharmacokinetics of arundic Acid, an astrocyte modulating agent, in acute ischemic stroke. Ishibashi, H., Pettigrew, L.C., Funakoshi, Y., Hiramatsu, M. Journal of clinical pharmacology (2007) [Pubmed]
  4. Neuroprotective effect of arundic acid, an astrocyte-modulating agent, in mouse brain against MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity. Himeda, T., Kadoguchi, N., Kamiyama, Y., Kato, H., Maegawa, H., Araki, T. Neuropharmacology (2006) [Pubmed]
  5. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTP neurotoxicity in mice. Kato, H., Kurosaki, R., Oki, C., Araki, T. Brain Res. (2004) [Pubmed]
  6. Expression of S100 protein and protective effect of arundic acid on the rat brain in chronic cerebral hypoperfusion. Ohtani, R., Tomimoto, H., Wakita, H., Kitaguchi, H., Nakaji, K., Takahashi, R. Brain Res. (2007) [Pubmed]
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