The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AGN-PC-007OHL     3-hydroxyoctanoic acid

Synonyms: AG-D-84960, CHEBI:37098, H3898_SIGMA, HMDB01954, AC1L1BIF, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Poly-3-hydroxyoctanoate

  • phaZPfi, the gene encoding the extracellular poly(3-hydroxyoctanoic acid) depolymerase of Pseudomonas fluorescens GK13, was cloned, sequenced, and characterized [1].
  • Moreover, the polymer accumulated in the recombinant E. coli consisted mainly of 3-hydroxyoctanoate monomers [2].
  • Twenty-five gram-negative bacteria and one gram-positive bacterium capable of growing on poly(3-hydroxyoctanoic acid) [P(3HO)] as the sole source of carbon and energy were isolated from various soils, lake water, and activated sludge [3].
  • This result also provided evidence for the presumption that the Burkholderia strain possesses not only polyhydroxybutyrate synthase genes, but also synthase for medium-chain-length polyhydroxyalkanoates consisting of 3HHx, 3HO and 3HD [4].
  • The kinetic DSC study of PHA granules, which contained mostly 3-hydroxyoctanoate units (PHO), in Pseudomonas putida BM01 cells showed that the polymer within the granules existed in an amorphous state, but it crystallized after dehydration of the cells under freeze-drying condition (below -50 degrees C) followed by annealing at ambient temperature [5].

High impact information on Poly-3-hydroxyoctanoate


Associations of Poly-3-hydroxyoctanoate with other chemical compounds


Gene context of Poly-3-hydroxyoctanoate

  • These included 24% poly-3-hydroxybutyrate (PHB), 41% poly-3-hydroxyvalerate (PHV), 18% poly-3-hydroxyhexanoate (PHH), 10% poly-3-hydroxyoctanoate (PHO), 5% poly-3-hydroxydecanoate (PHD). and 2% poly-3-hydroxydodecanoate (PHDD), indicating that microorganisms could store various PHAs through the different metabolic pathways [10].

Analytical, diagnostic and therapeutic context of Poly-3-hydroxyoctanoate


  1. Molecular characterization of the extracellular poly(3-hydroxyoctanoic acid) [P(3HO)] depolymerase gene of Pseudomonas fluorescens GK13 and of its gene product. Schirmer, A., Jendrossek, D. J. Bacteriol. (1994) [Pubmed]
  2. Production of medium-chain-length poly(3-hydroxyalkanoates) from gluconate by recombinant Escherichia coli. Klinke, S., Ren, Q., Witholt, B., Kessler, B. Appl. Environ. Microbiol. (1999) [Pubmed]
  3. Degradation of poly(3-hydroxyoctanoic acid) [P(3HO)] by bacteria: purification and properties of a P(3HO) depolymerase from Pseudomonas fluorescens GK13. Schirmer, A., Jendrossek, D., Schlegel, H.G. Appl. Environ. Microbiol. (1993) [Pubmed]
  4. PCR cloning of polyhydroxyalkanoate biosynthesis genes from Burkholderia caryophylli and their functional expression in recombinant Escherichia coli. Hang, X., Zhang, G., Wang, G., Zhao, X., Chen, G.Q. FEMS Microbiol. Lett. (2002) [Pubmed]
  5. Differential scanning calorimetric study of poly(3-hydroxyoctanoate) inclusions in bacterial cells. Song, J.J., Yoon, S.C., Yu, S.M., Lenz, R.W. Int. J. Biol. Macromol. (1998) [Pubmed]
  6. Bacterial poly(hydroxyalkanoates) as a source of chiral hydroxyalkanoic acids. Ren, Q., Grubelnik, A., Hoerler, M., Ruth, K., Hartmann, R., Felber, H., Zinn, M. Biomacromolecules (2005) [Pubmed]
  7. Metabolic engineering of Escherichia coli for the production of medium-chain-length polyhydroxyalkanoates rich in specific monomers. Park, S.J., Park, J.P., Lee, S.Y. FEMS Microbiol. Lett. (2002) [Pubmed]
  8. Substrate specificities of poly(hydroxyalkanoate)-degrading bacteria and active site studies on the extracellular poly(3-hydroxyoctanoic acid) depolymerase of Pseudomonas fluorescens GK13. Schirmer, A., Matz, C., Jendrossek, D. Can. J. Microbiol. (1995) [Pubmed]
  9. 3-Hydroxyoctanoic aciduria: identification of a new organic acid in the urine of a patient with non-ketotic hypoglycemia. Kelley, R.I., Morton, D.H. Clin. Chim. Acta (1988) [Pubmed]
  10. Behaviors of intercellular materials and nutrients in biological nutrient removal process supplied with domestic wastewater and food waste. Chae, S.R., Jeong, H.S., Lim, J.L., Kang, S.T., Shin, H.S., Paik, B.C., Youn, J.H. Water Environ. Res. (2004) [Pubmed]
  11. Production of chiral R-3-hydroxyalkanoic acids and R-3-hydroxyalkanoic acid methylesters via hydrolytic degradation of polyhydroxyalkanoate synthesized by pseudomonads. de Roo, G., Kellerhals, M.B., Ren, Q., Witholt, B., Kessler, B. Biotechnol. Bioeng. (2002) [Pubmed]
WikiGenes - Universities