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Chemical Compound Review

AC1NAURY     sodium decanoate

Synonyms: Sodium caprate, ACMC-2097ny, C4151_SIGMA, ANW-14204, LS-59381, ...
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Disease relevance of decanoic acid

 

High impact information on decanoic acid

 

Chemical compound and disease context of decanoic acid

  • Therefore, sodium glycocholate, sodium caprate and n-lauryl-beta-D-maltopyranoside are useful absorption enhancers due to their high absorption enhancing effects and low intestinal toxicity [8].
  • Cultivation of recombinant fadA and/or fadB mutant E. coli strains in LB medium containing 10 g/L of sodium gluconate and 2 g/L of sodium decanoate resulted in the production of PHA copolymer containing a very high fraction of 3HB up to 95 mol% [9].
  • When the fadA and/or fadB mutant E. coli strains harboring the plasmid containing the Pseudomonas sp. 61-3 phaC2 gene and the Ralstonia eutropha phaAB genes were cultured in Luria-Bertani (LB) medium supplemented with 2 g/L of sodium decanoate, all the recombinant E. coli strains synthesized PHAs consisting of C4, C6, C8, and C10 monomer units [9].
 

Biological context of decanoic acid

 

Anatomical context of decanoic acid

 

Associations of decanoic acid with other chemical compounds

 

Gene context of decanoic acid

 

Analytical, diagnostic and therapeutic context of decanoic acid

References

  1. Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn's disease. Söderholm, J.D., Olaison, G., Peterson, K.H., Franzén, L.E., Lindmark, T., Wirén, M., Tagesson, C., Sjödahl, R. Gut (2002) [Pubmed]
  2. Clinically applicable procedure for gene delivery to fetal gut by ultrasound-guided gastric injection: toward prenatal prevention of early-onset intestinal diseases. David, A.L., Peebles, D.M., Gregory, L., Waddington, S.N., Themis, M., Weisz, B., Ruthe, A., Lawrence, L., Cook, T., Rodeck, C.H., Coutelle, C. Hum. Gene Ther. (2006) [Pubmed]
  3. Effects of sodium deoxycholate and sodium caprate on the transport of epirubicin in human intestinal epithelial Caco-2 cell layers and everted gut sacs of rats. Lo, Y.L., Huang, J.D. Biochem. Pharmacol. (2000) [Pubmed]
  4. New FadB homologous enzymes and their use in enhanced biosynthesis of medium-chain-length polyhydroxyalkanoates in FadB mutant Escherichia coli. Park, S.J., Yup Lee, S. Biotechnol. Bioeng. (2004) [Pubmed]
  5. A novel method for the preclinical assessment of rectal irritation. Kinouchi, Y., Takeichi, Y., Yata, N. J. Pharm. Pharmacol. (1996) [Pubmed]
  6. Absorption-enhancing mechanism of sodium caprate and decanoylcarnitine in Caco-2 cells. Tomita, M., Hayashi, M., Awazu, S. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  7. Oral delivery of low-molecular-weight heparin using sodium caprate as absorption enhancer reaches therapeutic levels. Motlekar, N.A., Srivenugopal, K.S., Wachtel, M.S., Youan, B.B. Journal of drug targeting. (2005) [Pubmed]
  8. Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: their intestinal mucosal toxicity and absorption-enhancing mechanism of n-lauryl-beta-D-maltopyranoside. Uchiyama, T., Sugiyama, T., Quan, Y.S., Kotani, A., Okada, N., Fujita, T., Muranishi, S., Yamamoto, A. J. Pharm. Pharmacol. (1999) [Pubmed]
  9. Biosynthesis of poly(3-hydroxybutyrate- co-3-hydroxyalkanoates) by metabolically engineered Escherichia coli strains. Park, S.J., Lee, S.Y. Appl. Biochem. Biotechnol. (2004) [Pubmed]
  10. Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate. Lindmark, T., Söderholm, J.D., Olaison, G., Alván, G., Ocklind, G., Artursson, P. Pharm. Res. (1997) [Pubmed]
  11. Effect of absorption promoters on subcutaneous absorption of human epidermal growth factor in rats. Murakami, T., Misaki, M., Kojima, Y., Yamada, M., Yuki, M., Higashi, Y., Amagase, H., Fuwa, T., Yata, N. Journal of pharmaceutical sciences. (1993) [Pubmed]
  12. Effect of sodium caprate on the intestinal absorption of two modified antisense oligonucleotides in pigs. Raoof, A.A., Ramtoola, Z., McKenna, B., Yu, R.Z., Hardee, G., Geary, R.S. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2002) [Pubmed]
  13. Improvement in the bioavailability of poorly absorbed glycyrrhizin via various non-vascular administration routes in rats. Sasaki, K., Yonebayashi, S., Yoshida, M., Shimizu, K., Aotsuka, T., Takayama, K. International journal of pharmaceutics. (2003) [Pubmed]
  14. Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Anderberg, E.K., Lindmark, T., Artursson, P. Pharm. Res. (1993) [Pubmed]
  15. Absorption-enhancing mechanism of EDTA, caprate, and decanoylcarnitine in Caco-2 cells. Tomita, M., Hayashi, M., Awazu, S. Journal of pharmaceutical sciences. (1996) [Pubmed]
  16. Penetration of engineered antibody fragments into the eye. Thiel, M.A., Coster, D.J., Standfield, S.D., Brereton, H.M., Mavrangelos, C., Zola, H., Taylor, S., Yusim, A., Williams, K.A. Clin. Exp. Immunol. (2002) [Pubmed]
  17. Enhancement of blood-brain barrier permeability by sodium caprate. Ohnishi, T., Aida, K., Awazu, S. J. Pharm. Pharmacol. (1999) [Pubmed]
  18. Physiological mechanism for enhancement of paracellular drug transport. Hayashi, M., Sakai, T., Hasegawa, Y., Nishikawahara, T., Tomioka, H., Iida, A., Shimizu, N., Tomita, M., Awazu, S. Journal of controlled release : official journal of the Controlled Release Society. (1999) [Pubmed]
  19. Cytotoxicity of absorption enhancers in Caco-2 cell monolayers. Sakai, M., Imai, T., Ohtake, H., Otagiri, M. J. Pharm. Pharmacol. (1998) [Pubmed]
  20. The influence of caprate on rectal absorption of phenoxymethylpenicillin: experience from an in-vivo perfusion in humans. Lennernäs, H., Gjellan, K., Hallgren, R., Graffner, C. J. Pharm. Pharmacol. (2002) [Pubmed]
  21. Metabolic engineering of Escherichia coli for the production of medium-chain-length polyhydroxyalkanoates rich in specific monomers. Park, S.J., Park, J.P., Lee, S.Y. FEMS Microbiol. Lett. (2002) [Pubmed]
  22. Studies on the promoting effects of medium chain fatty acid salts on the nasal absorption of insulin in rats. Mishima, M., Wakita, Y., Nakano, M. J. Pharmacobio-dyn. (1987) [Pubmed]
  23. Reversible increase in tight junction permeability to macromolecules in rat ileal mucosa in vitro by sodium caprate, a constituent of milk fat. Söderholm, J.D., Oman, H., Blomquist, L., Veen, J., Lindmark, T., Olaison, G. Dig. Dis. Sci. (1998) [Pubmed]
 
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