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Chemical Compound Review

Dibrommethan     dibromomethane

Synonyms: Methylenbromid, CCRIS 939, AGN-PC-00PNUH, NSC-7293, ACMC-1BD9M, ...
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Disease relevance of dibromomethane

  • We examined the role of the O6-alkylguanine-DNA alkyltransferase encoded by ogt gene in the sensitivity of Escherichia coli to the mutagenic effects of the dibromoalkanes, dibromoethane and dibromomethane, by comparing responses in ogt- bacteria to those in their isogenic ogt+ parental counterparts [1].

High impact information on dibromomethane


Biological context of dibromomethane

  • Analysis of the reduction kinetics showed that CTB and BF were mainly reduced through hydrogenolysis reaction, while over 76% of DBM was reduced through concerted reductive debromination to methane [5].
  • The total DBM mass in the receptor solution and the skin was taken to represent an in vivo body burden [7].

Associations of dibromomethane with other chemical compounds

  • Exposures (DBM: 500 to 10,000 ppm; BCM: 2500 to 40,000 ppm) lasted 4 hr during which time five blood samples were drawn from jugular cannulae for analysis of the parent dihalomethane by gas chromatography [8].


  1. ogt alkyltransferase enhances dibromoalkane mutagenicity in excision repair-deficient Escherichia coli K-12. Abril, N., Luque-Romero, F.L., Prieto-Alamo, M.J., Margison, G.P., Pueyo, C. Mol. Carcinog. (1995) [Pubmed]
  2. Mammalian cells expressing Escherichia coli O6-alkylguanine-DNA alkyltransferases are hypersensitive to dibromoalkanes. Abril, N., Margison, G.P. Chem. Res. Toxicol. (1999) [Pubmed]
  3. Predicting vehicle effects on the dermal absorption of halogenated methanes using physiologically based modeling. Jepson, G.W., McDougal, J.N. Toxicol. Sci. (1999) [Pubmed]
  4. A physiological pharmacokinetic model for dermal absorption of vapors in the rat. McDougal, J.N., Jepson, G.W., Clewell, H.J., MacNaughton, M.G., Andersen, M.E. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
  5. Kinetic and mechanistic examinations of reductive transformation pathways of brominated methanes with nano-scale Fe and Ni/Fe particles. Lim, T.T., Feng, J., Zhu, B.W. Water Res. (2007) [Pubmed]
  6. Molecular interactions in crystalline dibromomethane and diiodomethane, and the stabilities of their high-pressure and low-temperature phases. Podsiad??o, M., Dziubek, K., Szafra??ski, M., Katrusiak, A. Acta Crystallogr., B (2006) [Pubmed]
  7. Short-Term dermal absorption and penetration of chemicals from aqueous solutions: theory and experiment. McDougal, J.N., Jurgens-Whitehead, J.L. Risk Anal. (2001) [Pubmed]
  8. Dermal absorption of dihalomethane vapors. McDougal, J.N., Jepson, G.W., Clewell, H.J., Andersen, M.E. Toxicol. Appl. Pharmacol. (1985) [Pubmed]
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