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Chemical Compound Review

Bromoform     tribromomethane

Synonyms: Bromoforme, Bromoformio, Tribrommethan, Tribromometan, Tribrommethaan, ...
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Disease relevance of Tribromodeuteriomethane


High impact information on Tribromodeuteriomethane


Biological context of Tribromodeuteriomethane


Anatomical context of Tribromodeuteriomethane

  • Free radical intermediates were also detected during the aerobic and anaerobic incubation of isolated hepatocytes with bromoform (CHBr3), and iodoform (CHI3) [16].
  • In the present study, bromoform was tested in the mouse bone marrow micronucleus test in order to reassess the response in this system; all three compounds were evaluated using the rat liver unscheduled DNA synthesis test [15].
  • Hydrophobic nonionic compounds, such as bromoform and chloroform, exhibited a high initial rejection, as a result of both hydrophobic-hydrophobic solute-membrane interactions and steric exclusion, but rejection decreased significantly after 10 hours of operation because of partitioning of solutes through the membranes [17].

Associations of Tribromodeuteriomethane with other chemical compounds

  • GLC determination of PPB levels of citrate by conversion to bromoform [18].
  • At least some of them (bromodichloromethane, bromoform) have been shown to be carcinogenic in laboratory animals [19].
  • Analysis of the reduction kinetics showed that CTB and BF were mainly reduced through hydrogenolysis reaction, while over 76% of DBM was reduced through concerted reductive debromination to methane [20].
  • In vitro studies were conducted using 0.1-0.5 ml whole blood, or an equivalent mixture of water and n-octanol exposed to varying amounts of VOCs (BF, 0.11-11.4 micromol; CB, 0.11-24.6 micromol; CF, 0.11-186.6 micromol; and EB, 0.11-20.2 micromol) in sealed glass vials [21].

Gene context of Tribromodeuteriomethane


Analytical, diagnostic and therapeutic context of Tribromodeuteriomethane

  • A new solvate of griseofulvin wih bromoform was characterized by Raman spectroscopy [23].
  • Bromoform or chloroform was added to the mobile phase in HPLC to compare the difference between bromine and chlorine adducted ions [24].
  • To evaluate this phenomenon in humans, we have examined the genotoxicity of a brominated THM, bromoform (BF), using the Comet assay in human whole blood cultures exposed in vitro [25].


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  4. Absence of potentiation of bromoform hepatotoxicity and lethality by chlordecone. Agarwal, A.K., Mehendale, H.M. Toxicol. Lett. (1983) [Pubmed]
  5. Use of the SOS chromotest, the Ames-fluctuation test and the newt micronucleus test to study the genotoxicity of four trihalomethanes. Le Curieux, F., Gauthier, L., Erb, F., Marzin, D. Mutagenesis (1995) [Pubmed]
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  7. Structural basis for the inhibition of firefly luciferase by a general anesthetic. Franks, N.P., Jenkins, A., Conti, E., Lieb, W.R., Brick, P. Biophys. J. (1998) [Pubmed]
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  9. Molecular volume determines the activity of the halogenated alkane bromoform at wild-type and mutant GABA(A) receptors. Kash, T.L., Jenkins, A., Harrison, N.L. Brain Res. (2003) [Pubmed]
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  11. Field bean protease inhibitor mitigates the sister-chromatid exchanges induced by bromoform and depresses the spontaneous sister-chromatid exchange frequency of human lymphocytes in vitro. Banerji, A.P., Fernandes, A.O. Mutat. Res. (1996) [Pubmed]
  12. Metabolism of haloforms to carbon monoxide. I. In vitro studies. Ahmed, A.E., Kubic, V.L., Anders, M.W. Drug Metab. Dispos. (1977) [Pubmed]
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  15. Assessment of the potential in vivo genotoxicity of three trihalomethanes: chlorodibromomethane, bromodichloromethane and bromoform. Stocker, K.J., Statham, J., Howard, W.R., Proudlock, R.J. Mutagenesis (1997) [Pubmed]
  16. Activation of chloroform and related trihalomethanes to free radical intermediates in isolated hepatocytes and in the rat in vivo as detected by the ESR-spin trapping technique. Tomasi, A., Albano, E., Biasi, F., Slater, T.F., Vannini, V., Dianzani, M.U. Chem. Biol. Interact. (1985) [Pubmed]
  17. Rejection of emerging organic micropollutants in nanofiltration-reverse osmosis membrane applications. Xu, P., Drewes, J.E., Bellona, C., Amy, G., Kim, T.U., Adam, M., Heberer, T. Water Environ. Res. (2005) [Pubmed]
  18. GLC determination of PPB levels of citrate by conversion to bromoform. Bjork, R.G. Anal. Biochem. (1975) [Pubmed]
  19. Experimental cancer studies of chlorinated by-products. Komulainen, H. Toxicology (2004) [Pubmed]
  20. Kinetic and mechanistic examinations of reductive transformation pathways of brominated methanes with nano-scale Fe and Ni/Fe particles. Lim, T.T., Feng, J., Zhu, B.W. Water Res. (2007) [Pubmed]
  21. Concentration dependency of rat blood: air partition coefficients of some volatile organic chemicals. Béliveau, M., Krishnan, K. J. Toxicol. Environ. Health Part A (2000) [Pubmed]
  22. Molecular elimination of Br2 in 248 nm photolysis of bromoform probed by using cavity ring-down absorption spectroscopy. Huang, H.Y., Chuang, W.T., Sharma, R.C., Hsu, C.Y., Lin, K.C., Hu, C.H. The Journal of chemical physics. (2004) [Pubmed]
  23. Laser Raman investigation of pharmaceutical solids: griseofulvin and its solvates. Bolton, B.A., Prasad, P.N. Journal of pharmaceutical sciences. (1981) [Pubmed]
  24. Analysis of beta-lactam antibiotics by high performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry using bromoform. Horimoto, S., Mayumi, T., Aoe, K., Nishimura, N., Sato, T. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
  25. Induction of genetic damage in human lymphocytes and mutations in Salmonella by trihalomethanes: role of red blood cells and GSTT1-1 polymorphism. Landi, S., Hanley, N.M., Warren, S.H., Pegram, R.A., DeMarini, D.M. Mutagenesis (1999) [Pubmed]
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