Disease relevance of Dichlorophen

• The sequences of the complete hepatitis B surface antifen (HBsAg) genes were obtained from 18 coinfected Japanese patients [1].
• Chronic toxicity data were not available for Dichlorophene [2].
• A review has been made of the advances in knowledge on the treatment of tapeworm infections of man and animals from the time of the introduction to dichlorophen in 1956 [3].
• A culture of Pseudomonas aeruginosa, isolated from a cooling water system, was grown in the presence of sub-inhibitory concentrations of 2,2'-methylenebis(4-chlorophenol) (MBC) [4].

High impact information on Dichlorophen

• The hybrid nature of these cells was established by HAT or HAT-ouabain selective procedures, their chromosome number, and, in one case, H-2 surface antifen expression [5].
• Trophozoites of G. lamblia and T. vaginalis could be killed in shorter than 10 min with 0.074 mM dichlorophene and 0.0025 mM hexachlorophene, respectively, in serum-free media [6].
• Sulphation and diglucuronidation as constraints to enterohepatic circulation of dichlorophen in rats [7].
• No reproductive or developmental toxicity data were available for Dichlorophene, but there was some evidence of non-dose-dependent developmental toxicity with Chlorophene in rabbits [2].

Analytical, diagnostic and therapeutic context of Dichlorophen

• This HPLC system was shown to isolate dichlorophen from its major impurity (the trimer) [8].

References