Disease relevance of Cestode Infections

• Intestinal cestode infections respond to treatment with niclosamide and cerebral cysticercosis to praziquantel, but echinococcal hydatid disease still requires surgical intervention in certain cases, although prolonged treatment with mebendazole shows promise [1].
• Anthelmintic drugs of choice include: mebendazole for roundworm, pinworm, whipworm and hookworm infections; niclosamide for tapeworm infections, and thiabendazole for trichinosis [2].

High impact information on Cestode Infections

• Recent emigrants from countries in which T. solium infection is endemic should be screened for tapeworm infection in their stools before they are employed as housekeepers or food handlers [3].
• Niclosamide therapy for tapeworm infections [4].
• If found safe in humans, oxfendazole may prove to be a useful and inexpensive treatment for cestode infections in humans [5].
• Species-specific identification of human tapeworm infections is important for public health purposes, because prompt identification of Taenia solium carriers may prevent further human cysticercosis infections (a major cause of acquired epilepsy) [6].
• Sera from patients either with other cestode infections or with another illness were used as controls [7].

Chemical compound and disease context of Cestode Infections

• Significance of particle size of mebendazole in the treatment of tapeworm infections [8].
• A total of 870 patients, both males and females, from 3 to 79 years old, received either albendazole or a placebo for the treatment of nematode and cestode infections [9].
• Of the tapeworm-secreted compounds tested, only lumenal infusion of guanosine 3',5'-cyclic monophosphate (cGMP) induced contractile patterns that mimic those observed during tapeworm infection [10].
• Regulation of the immune response to cestode infection by progesterone is due to its metabolism to estradiol [11].
• Endogenous and 2-propanol-supported respiration of intact trophozoites of of Entamoeba histolytica (stain HM-1:IMSS) were inhibited by bithionol, an effective chemotherapeutic agent for some trematode and cestode infections in humans [12].

Biological context of Cestode Infections

• The development of highly polymorphic markers such as microsatellites in T. solium can provide the means to examine genetic heterogeneity of tapeworm infection at the household, community and regional level [13].

Gene context of Cestode Infections

• An enzymatic method (phospholipase B) for studies on cestode infection (Hymenolepis nana) and its suppression by chemotherapy [14].
• In primary T. hydatigena infections, host class I and class II MHC antigens were shown, for the first time in cestode infections, to be absorbed onto the surface of the metacestode bladderwall indicating their possible involvement in parasite survival [15].

Analytical, diagnostic and therapeutic context of Cestode Infections

• A diphyllobothriid cestode infection found in a 54-year-old male residing in Oita, Japan, was successfully treated by oral administration of Gastrografin in combination with a intramuscular injection of Vagostigmin [16].

References