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Chemical Compound Review

Dermazin     4-amino-N-pyrimidin-2-yl...

Synonyms: Sildaflo, Dermazine, Silvadene, Sulfargen, Silbertone, ...
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Disease relevance of sulfadiazine

  • Clinical wound infection with Staph, aureus developed in one Silvazine treated patient and five Flamazine treated patients (P = 0.16) [1].
 

High impact information on sulfadiazine

  • A novel intravascular catheter impregnated with the antiseptics silver-sulphadiazine and chlorhexidine was tested in an in-vivo model using implantation of catheters into the internal jugular veins of rats [2].
  • This study also compared the effects of BS and BO with Flamazine cream, which is currently the most popular drug for wound healing in hospitals [3].
  • Seventy-two hour exposure to Silvazine in the present study results in almost no keratinocyte survival at all and a highly statistically significant reduction in cell survival relative to control, Acticoat and Flamazine (P<0.001, P<0.01, P<0.01, respectively) [4].
  • Flamazine is associated with a statistically significant reduction in cell numbers relative to control (P<0.05), but is much less cytotoxic than Silvazine (P<0.005) [4].
  • We performed Minimal Inhibitory Concentration (MIC)-testings of 40 clinical isolates of M. pachydermatis against climbazole (CLIM), clotrimazole (CLOT) and silver-sulphadiazine (SILV) [5].
 

Chemical compound and disease context of sulfadiazine

 

Analytical, diagnostic and therapeutic context of sulfadiazine

References

  1. Prospective comparison of silver sulfadiazine 1 per cent plus chlorhexidine digluconate 0.2 per cent (Silvazine) and silver sulfadiazine 1 per cent (Flamazine) as prophylaxis against burn wound infection. Inman, R.J., Snelling, C.F., Roberts, F.J., Shaw, K., Boyle, J.C. Burns, including thermal injury. (1984) [Pubmed]
  2. Prevention of bacterial colonization of intravenous catheters by antiseptic impregnation of polyurethane polymers. Bach, A., Böhrer, H., Motsch, J., Martin, E., Geiss, H.K., Sonntag, H.G. J. Antimicrob. Chemother. (1994) [Pubmed]
  3. Synergistic effect of bismuth subgallate and borneol, the major components of Sulbogin, on the healing of skin wound. Mai, L.M., Lin, C.Y., Chen, C.Y., Tsai, Y.C. Biomaterials (2003) [Pubmed]
  4. Cytotoxicity of topical antimicrobial agents used in burn wounds in Australasia. Fraser, J.F., Cuttle, L., Kempf, M., Kimble, R.M. ANZ journal of surgery. (2004) [Pubmed]
  5. In vitro activity of climbazole, clotrimazole and silver-sulphadiazine against isolates of Malassezia pachydermatis. Schmidt, A. Zentralblatt Veterinarmedizin Reihe B (1997) [Pubmed]
  6. Pharmacology and clinical use of silver sulfadiazine and related topical antimicrobial agents. Fox, C.L. Pahlavi medical journal. (1977) [Pubmed]
  7. Patch test reactions to Flamazine. Rasmussen, I. Contact Derm. (1984) [Pubmed]
  8. Management of the frostbitten hand. Page, R.E., Robertson, G.A. The Hand. (1983) [Pubmed]
  9. Use of Flamazine cream to reduce infection following skin grafting. Srivastava, S., Wharton, S. British journal of plastic surgery. (2000) [Pubmed]
 
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