Disease relevance of Skin Transplantation

• The findings demonstrate that captopril ingestion enhanced granulomatous inflammation induced by skin transplantation of schistosome egg granulomas and significantly increased isograft takes [1].
• Full-thickness skin grafting of eyelids in a patient with generalized morphea taking thalidomide [2].
• The palmoplantar keratoderma failed to improve with etretinate, but considerable benefit resulted from full-thickness excision of the skin of both palms, followed by skin grafting [3].
• Significant complications included: one case of decubitus ulcers requiring skin-grafting, one episode of mild hypotension in a patient with terminal malignancy, requiring ephedrine and phenylephrine, and one mild toxic reaction on test dosing due to presumed intravascular migration of a lumber sympathetic catheter [4].
• Free, autogenous, full-thickness skin grafting was performed on 10 dogs; 5 dogs were given an iron chelator, deferoxamine-10% hydroxyethyl pentafraction starch (DEF-HES; 50 mg/kg of body weight, IV), and 5 dogs were given 10% hydroxyethyl pentafraction starch (HES) in 0.9% saline solution (5 ml/kg, IV) [5].

High impact information on Skin Transplantation

• We studied antigen-specific T-cell tolerization therapy using skin transplantation across a defined minor histocompatibility antigen difference [6].
• Wachtel and his colleagues proposed that this testis-determining function of the Y is mediated by the male-specific cell-surface antigen H-Y, originally defined by skin grafting [7].
• Spleen cells from mice presensitized in vivo by skin grafting were restimulated in vitro and tested against 51Cr-labeled concanavalin A or lipopolysaccharide blasts [8].
• Spleen cells of control female chimeras primed by grafting and rejection of H-Y (Skn-compatible) B6 male skin failed to incite the Skn-typical cutaneous lesions in (B6 x A)F1 recipients, indicating that these lesions were Skn-specific and not a nonspecific consequence of incompatible skin grafting per se [9].
• In this study, we demonstrated the direct regulatory effects of CD1d-dependent NKT cells using an allogeneic skin transplantation model [10].

Chemical compound and disease context of Skin Transplantation

• Carbon dioxide and argon lasers (HGM Medical Laboratories, Salt Lake City, Utah) and Merocel stenting wicks with split-thickness skin grafting were used to try to improve long-term hearing outcome and decrease postoperative external auditory canal stenosis [11].
• Phenytoin induced rhinophyma treated by excision and full thickness skin grafting [12].
• We report the successful split-thickness skin grafting of a hydroxyurea-related ankle ulceration after preoperative discontinuation of hydroxyurea treatment in a patient with chronic myelogenous leukemia who had previously failed grafting while taking this medication [13].
• This case study suggests that 3M Coban Self-Adherent Wraps were effective in reducing edema in the skin-grafted hand after skin grafting [14].

Biological context of Skin Transplantation

• The possibility that retroviral insertions into the mouse genome resulted in gain or loss mutations at non-H-2 histocompatibility loci was investigated by reciprocal skin grafting between Mov mice and mice from coisogenic, background strains [15].
• Furthermore, from experiments of skin grafting, we demonstrated that tolerance to minor histocompatibility Ag was also achieved in the presence of peripheral hemopoietic chimerism [16].
• Genetics of histocompatibility in mice. II. Survey for interactions between minor (non-H-2) antigens by skin grafting [17].
• Anti-inflammatory cytokine levels of IL-4 were elevated in HIV-infected volunteers compared to healthy volunteers and burn patients (p<0.05).CONCLUSION: Graft survival after split skin grafting of burn wounds in HIV-infected patients is impaired and hospital stay is prolonged [18].
• A single dose of 1 mg per mouse of ZS RNase or 3M-P administered i.p. on day 4 after skin transplantation significantly prolonged graft rejection [19].

Anatomical context of Skin Transplantation

• Although 14 of 17 control mice rejected EGFP.Tg skin grafts within 100 days, 24 of 25 mice receiving EGFP-expressing bone marrow cells accepted their B6-EGFP.Tg grafts out to 200 days after skin grafting, including animals with undetectable levels of EGFP expression in blood cells [20].
• After immunization of C3H mice by skin grafting or by i.p. or footpad injection of F1 hybrid spleen cells, draining lymph nodes show increased responsiveness toward the immunizing histocompatibility determinants for at least 3 months after immunization [21].
• Based on this experience we prefer reconstruction of rigidity by means of a vicryl mesh and of soft tissue coverage by omentum transposition and split skin grafting [22].
• BACKGROUND: Among various surgical therapies for replenishment of melanocytes in recalcitrant and stable vitiligo, punch skin grafting (PSG) and suction blister epidermal grafting (SBEG) are the simplest ones [23].
• However, simple split-thickness skin grafting on full-thickness defects of the skin on the flexor side of the forearm results in deformations, pigmentation, and the adhesion of the graft to the tendons [24].

Associations of Skin Transplantation with chemical compounds

• Skin transplantation in mice and dogs. Effect of cyclosporin A and dihydrocyclosporin C [25].
• 1-Ethyl-1-nitrosourea (ENU) failed to induce de novo MHC mutations in male mice in our skin grafting series [26].
• Very small amounts (0.5 to 2 microliters) of H-2-incompatible blood given 16 days before skin grafting led to the induction of a long-lived unresponsiveness when the mice were given a short postoperative course of alternating doses of procarbazine hydrochloride and antilymphocyte serum [27].
• The levels of TxB2 and PGE2 produced by lymphoid organs were measured in the early/late post-partum periods and immediately before and after skin grafting in B10.S mice (H-2s/I-E-) that had been injected at birth with (B10.S x B10.A)F1 (H-2k/d, I-E+) lymphohematopoietic cells [28].
• Subsequent therapy for the remaining 53 women involved 44 additional superficial photovaporizations, 38 courses of therapeutic 5-FU, four deep laser destructions with skin grafting, and six trials of systemic alpha-interferon [29].

Gene context of Skin Transplantation

• Mice heterozygous for a targeted deletion of IL-2 from the histocompatible C3.129P2(B6)-Il2(tm1Hor) substrain, that produce reduced levels of IL-2, were examined for AA development after grafting skin from AA-affected C3H/HeJ mice [30].
• IL-1Ra increased significantly after debridement and skin transplantation (preoperatively 742 [range 488 to 1506] vs. postoperatively 1431 [range 1286 to 2107] pg/mL; p < .01) [31].
• Of the 52 MRSA patients, 40 had 101 sessions of skin grafting and 33 of them survived [32].
• Using a skin transplantation model, we found that perforin-deficient mice are resistant to the induction of allograft acceptance by agents that block T cell costimulation [33].
• T cell function of "lethargic" mutant mice which exhibit spontaneous thymic involution was evaluated by skin transplantation and graft-versus-host reaction tests [34].

Analytical, diagnostic and therapeutic context of Skin Transplantation

• Other grafts were followed until rejection with donor/third-party skin grafting, adoptive transfer, and interleukin 2 infusion studies in selected recipients [35].
• Although cyclosporine (CsA) is a powerful immunosuppressive agent in organ transplantation, its efficacy in skin transplantation has not been examined completely [36].
• Intradermal injection of epinephrine to decrease blood loss during split-thickness skin grafting [37].
• INTERVENTIONS: Study group studied by sprinkling phenytoin powder and the control group with EUSOL, in both groups the ulcers were addressed daily and followed up for 28 days or until they epithelialised or were ready for skin grafting [38].
• METHODS: Forty patients scheduled for tympanoplasty or skin grafting under sevoflurane anesthesia were assigned to four groups [39].

References