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MeSH Review

Skin Transplantation

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Disease relevance of Skin Transplantation


High impact information on Skin Transplantation

  • We studied antigen-specific T-cell tolerization therapy using skin transplantation across a defined minor histocompatibility antigen difference [6].
  • Wachtel and his colleagues proposed that this testis-determining function of the Y is mediated by the male-specific cell-surface antigen H-Y, originally defined by skin grafting [7].
  • Spleen cells from mice presensitized in vivo by skin grafting were restimulated in vitro and tested against 51Cr-labeled concanavalin A or lipopolysaccharide blasts [8].
  • Spleen cells of control female chimeras primed by grafting and rejection of H-Y (Skn-compatible) B6 male skin failed to incite the Skn-typical cutaneous lesions in (B6 x A)F1 recipients, indicating that these lesions were Skn-specific and not a nonspecific consequence of incompatible skin grafting per se [9].
  • In this study, we demonstrated the direct regulatory effects of CD1d-dependent NKT cells using an allogeneic skin transplantation model [10].

Chemical compound and disease context of Skin Transplantation


Biological context of Skin Transplantation


Anatomical context of Skin Transplantation

  • Although 14 of 17 control mice rejected EGFP.Tg skin grafts within 100 days, 24 of 25 mice receiving EGFP-expressing bone marrow cells accepted their B6-EGFP.Tg grafts out to 200 days after skin grafting, including animals with undetectable levels of EGFP expression in blood cells [20].
  • After immunization of C3H mice by skin grafting or by i.p. or footpad injection of F1 hybrid spleen cells, draining lymph nodes show increased responsiveness toward the immunizing histocompatibility determinants for at least 3 months after immunization [21].
  • Based on this experience we prefer reconstruction of rigidity by means of a vicryl mesh and of soft tissue coverage by omentum transposition and split skin grafting [22].
  • BACKGROUND: Among various surgical therapies for replenishment of melanocytes in recalcitrant and stable vitiligo, punch skin grafting (PSG) and suction blister epidermal grafting (SBEG) are the simplest ones [23].
  • However, simple split-thickness skin grafting on full-thickness defects of the skin on the flexor side of the forearm results in deformations, pigmentation, and the adhesion of the graft to the tendons [24].

Associations of Skin Transplantation with chemical compounds

  • Skin transplantation in mice and dogs. Effect of cyclosporin A and dihydrocyclosporin C [25].
  • 1-Ethyl-1-nitrosourea (ENU) failed to induce de novo MHC mutations in male mice in our skin grafting series [26].
  • Very small amounts (0.5 to 2 microliters) of H-2-incompatible blood given 16 days before skin grafting led to the induction of a long-lived unresponsiveness when the mice were given a short postoperative course of alternating doses of procarbazine hydrochloride and antilymphocyte serum [27].
  • The levels of TxB2 and PGE2 produced by lymphoid organs were measured in the early/late post-partum periods and immediately before and after skin grafting in B10.S mice (H-2s/I-E-) that had been injected at birth with (B10.S x B10.A)F1 (H-2k/d, I-E+) lymphohematopoietic cells [28].
  • Subsequent therapy for the remaining 53 women involved 44 additional superficial photovaporizations, 38 courses of therapeutic 5-FU, four deep laser destructions with skin grafting, and six trials of systemic alpha-interferon [29].

Gene context of Skin Transplantation


Analytical, diagnostic and therapeutic context of Skin Transplantation


  1. Effect of captopril on transplanted schistosome egg granulomas in skin. Epstein, W.L., Higuchi, M., Izaki, S., Fukuyama, K. J. Invest. Dermatol. (1985) [Pubmed]
  2. Full-thickness skin grafting of eyelids in a patient with generalized morphea taking thalidomide. Periman, L.M., Sires, B.S. Arch. Ophthalmol. (2000) [Pubmed]
  3. Mutilating palmoplantar keratoderma with periorificial keratotic plaques (Olmsted's syndrome). Atherton, D.J., Sutton, C., Jones, B.M. Br. J. Dermatol. (1990) [Pubmed]
  4. Regional analgesia on pediatric medical and surgical wards. Berde, C.B., Sethna, N.F., Levin, L., Retik, A., Millis, M., Lillehei, C., Micheli, L. Intensive care medicine. (1989) [Pubmed]
  5. Effect of deferoxamine-hydroxyethyl pentafraction starch on free, autogenous full-thickness skin grafts in dogs. Hosgood, G., Lewis, D.D., Hodgin, E.C., Church, D.F., Lopez, M.K. Am. J. Vet. Res. (1993) [Pubmed]
  6. Antigen persistence and time of T-cell tolerization determine the efficacy of tolerization protocols for prevention of skin graft rejection. Ehl, S., Aichele, P., Ramseier, H., Barchet, W., Hombach, J., Pircher, H., Hengartner, H., Zinkernagel, R.M. Nat. Med. (1998) [Pubmed]
  7. Spermatogenic failure in male mice lacking H-Y antigen. Burgoyne, P.S., Levy, E.R., McLaren, A. Nature (1986) [Pubmed]
  8. Histocompatibility antigens controlled by the I region of the murine H-2 complex. I. Mapping of H-2A and H-2C loci. Klein, J., Geib, R., Chiang, C., Hauptfeld, V. J. Exp. Med. (1976) [Pubmed]
  9. Adoptive transfer of skin-selective autoimmunity induced by Skn alloantigenic disparities. Jackman, S.H., Boyse, E.A., Goldberg, E.H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  10. Direct regulatory role of NKT cells in allogeneic graft survival is dependent on the quantitative strength of antigenicity. Oh, K., Kim, S., Park, S.H., Gu, H., Roopenian, D., Chung, D.H., Kim, Y.S., Lee, D.S. J. Immunol. (2005) [Pubmed]
  11. Surgery of congenital aural atresia. Chandrasekhar, S.S., De la Cruz, A., Garrido, E. The American journal of otology. (1995) [Pubmed]
  12. Phenytoin induced rhinophyma treated by excision and full thickness skin grafting. Jaramillo, M.J., Stewart, K.J., Kolhe, P.S. British journal of plastic surgery. (2000) [Pubmed]
  13. Hydroxyurea-related ankle ulcers in patients with myeloproliferative disorders: a case report and review of the literature. Cox, C., Nowicky, D., Young, R. Annals of plastic surgery. (1997) [Pubmed]
  14. Effect of 3M Coban Self-Adherent Wraps on edema and function of the burned hand: a case study. Lowell, M., Pirc, P., Ward, R.S., Lundy, C., Wilhelm, D.A., Reddy, R., Held, B., Bernard, J. The Journal of burn care & rehabilitation. (2003) [Pubmed]
  15. Endogenous retroviruses lead to the expression of a histocompatibility antigen detectable by skin graft rejection. Colombo, M.P., Jaenisch, R., Wettstein, P.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  16. Role of peripheral hemopoietic chimerism in achieving donor-specific tolerance in adult mice. Maeda, T., Eto, M., Nishimura, Y., Nomoto, K., Kong, Y.Y., Nomoto, K. J. Immunol. (1993) [Pubmed]
  17. Genetics of histocompatibility in mice. II. Survey for interactions between minor (non-H-2) antigens by skin grafting. Johnson, L.L., Bailey, D.W., Mobraaten, L.E. Immunogenetics (1980) [Pubmed]
  18. HIV infection reduces skin graft survival in burn injuries: a prospective study. Mzezewa, S., Jönsson, K., Sibanda, E., Aberg, M., Salemark, L. British journal of plastic surgery. (2003) [Pubmed]
  19. Immunosuppressive effects of bovine seminal fluid fractions with ribonuclease activity. Soucek, J., Hrubá, A., Paluska, E., Chudomel, V., Dostál, J., Matousek, J. Folia Biol. (Praha) (1983) [Pubmed]
  20. Engraftment of retroviral EGFP-transduced bone marrow in mice prevents rejection of EGFP-transgenic skin grafts. Andersson, G., Denaro, M., Johnson, K., Morgan, P., Sullivan, A., Houser, S., Patience, C., White-Scharf, M.E., Down, J.D. Mol. Ther. (2003) [Pubmed]
  21. Local cellular immunity in the draining lymph nodes of mice after immunization with histocompatibility alloantigens. Snow, C., Hilgard, H.R. Transplantation (1981) [Pubmed]
  22. Chest wall resection in the treatment of local recurrence of breast cancer. Zoetmulder, F.A., van Dongen, J.A. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. (1988) [Pubmed]
  23. Suction blister epidermal grafting versus punch skin grafting in recalcitrant and stable vitiligo. Gupta, S., Jain, V.K., Saraswat, P.K. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (1999) [Pubmed]
  24. The use of artificial dermis on the donor defect of the free forearm flap. Tane, N., Aihara, M., Inoue, H. Journal of reconstructive microsurgery. (1996) [Pubmed]
  25. Skin transplantation in mice and dogs. Effect of cyclosporin A and dihydrocyclosporin C. Borel, J.F., Meszaros, J. Transplantation (1980) [Pubmed]
  26. Detection of new MHC mutations in mice by skin grafting, tumor transplantation and monoclonal antibodies: a comparison. Egorov, I.K., Egorov, O.S. Genetics (1988) [Pubmed]
  27. Specific unresponsiveness to skin allografts in mice. VI. Graft survival in mice pretreated with blood. Wood, P., Horsburgh, T., Brent, L. Transplantation (1981) [Pubmed]
  28. Lymphoid organ production of immunomodulatory eicosanoids in mice resistant to neonatal tolerance induction. Nassiri, M., Viciana, A., Padmanabhan, J., Streilein, J.W., Ruiz, P. Transplantation (1994) [Pubmed]
  29. Superficial laser vulvectomy. IV. Extended laser vaporization and adjunctive 5-fluorouracil therapy of human papillomavirus-associated vulvar disease. Reid, R., Greenberg, M.D., Lörincz, A.T., Daoud, Y., Pizzuti, D., Stoler, M. Obstetrics and gynecology. (1990) [Pubmed]
  30. Reduced expression of interleukin-2 decreases the frequency of alopecia areata onset in C3H/HeJ mice. Freyschmidt-Paul, P., McElwee, K.J., Hoffmann, R., Sundberg, J.P., Kissling, S., Hummel, S., Vitacolonna, M., Kopp-Schneider, A., Zöller, M. J. Invest. Dermatol. (2005) [Pubmed]
  31. Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury. Mandrup-Poulsen, T., Wogensen, L.D., Jensen, M., Svensson, P., Nilsson, P., Emdal, T., Mølvig, J., Dinarello, C.A., Nerup, J. Crit. Care Med. (1995) [Pubmed]
  32. Staphylococcal septicaemia in burns. Gang, R.K., Sanyal, S.C., Bang, R.L., Mokaddas, E., Lari, A.R. Burns : journal of the International Society for Burn Injuries. (2000) [Pubmed]
  33. Cutting edge: perforin down-regulates CD4 and CD8 T cell-mediated immune responses to a transplanted organ. Bose, A., Inoue, Y., Kokko, K.E., Lakkis, F.G. J. Immunol. (2003) [Pubmed]
  34. Deficiency in the thymus-dependent immunity in "lethargic" mutant mice. Dung, H.C. Transplantation (1977) [Pubmed]
  35. Antisense oligodeoxynucleotides prevent acute cardiac allograft rejection via a novel, nontoxic, highly efficient transfection method. Poston, R.S., Mann, M.J., Hoyt, E.G., Ennen, M., Dzau, V.J., Robbins, R.C. Transplantation (1999) [Pubmed]
  36. Cyclosporine and experimental skin allografts: long-term survival in rats treated with low maintenance doses. Towpik, E., Kupiec-Weglinski, J.W., Tyler, D.S., Araujo, J.L., Schneider, T.M., Araneda, D., Murphy, G.M., Tilney, N.L. Plast. Reconstr. Surg. (1986) [Pubmed]
  37. Intradermal injection of epinephrine to decrease blood loss during split-thickness skin grafting. Hughes, W.B., DeClement, F.A., Hensell, D.O. The Journal of burn care & rehabilitation. (1996) [Pubmed]
  38. Topical phenytoin versus EUSOL in the treatment of non-malignant chronic leg ulcers. Carneiro, P.M., Nyawawa, E.T. East African medical journal. (2003) [Pubmed]
  39. What is the optimal dose of glucose administration during minor surgery under sevoflurane anesthesia? Terajima, K., Ogawa, R. Journal of anesthesia. (2000) [Pubmed]
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