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Chemical Compound Review

Acide tibrique     2-chloro-5-[[(3S,5R)-3,5- dimethyl-1...

Synonyms: CCRIS 589, Tibric acid, Acido tibrico, SureCN635365, CHEMBL2104748, ...
 
 
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Disease relevance of CCRIS 589

 

High impact information on CCRIS 589

 

Biological context of CCRIS 589

 

Associations of CCRIS 589 with other chemical compounds

 

Analytical, diagnostic and therapeutic context of CCRIS 589

  • This double-blind study compares the effects of tibric acid at four different doses to that of placebo in type IV hyperlipidemic patients [2].
  • Residues from these extracts that contained more than 5 ppm of tibric acid were analyzed by HPLC, whereas GC was required for levels below 5 ppm [8].

References

  1. The hepatic effects of hypolipidemic drugs (clofibrate, nafenopin, tibric acid, and Wy-14,643) on hepatic peroxisomes and peroxisome-associated enzymes. Moody, D.E., Reddy, J.K. Am. J. Pathol. (1978) [Pubmed]
  2. Dose-response to tibric acid: a new hypolipidemic drug in type IV hyperlipoproteinemia. Bielmann, P., Brun, D., Moorjani, S., Gagné, C., Lupien, P., Tétreault, L. Clin. Pharmacol. Ther. (1975) [Pubmed]
  3. Hepatic peroxisome proliferation: induction by two novel compounds structurally unrelated to clofibrate. Reddy, J.K., Krishnakantha, T.P. Science (1975) [Pubmed]
  4. Hypolipidemic drugs are inhibitors of phosphatidylcholine synthesis. Parthasarathy, S., Kritchevsky, D., Baumann, W.J. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  5. The effect of hypolipidemic agents on the hepatic microsomal drug-metabolizing enzyme system of the rat. Induction of cytochrome(s) P-450 with specificity toward terminal hydroxylation of lauric acid. Orton, T.C., Parker, G.L. Drug Metab. Dispos. (1982) [Pubmed]
  6. Saturable binding sites for the coenzyme A ester of nafenopin, a peroxisome proliferator, in rat liver cytosol. Morgan, C., Bronfman, M. Xenobiotica (1995) [Pubmed]
  7. Influence of four agents (tibric acid, DH 990, oxandrolone and Sch 9122) on aspects of lipid metabolism in rats). Kritchevsky, D., Tepper, S.A., Story, J.A. Arzneimittel-Forschung. (1976) [Pubmed]
  8. Determination of tibric acid and clofibrate in animal feed, wastewater and hunan urine. Oller, W.L., Kendall, D.C., Bowman, M.C. Journal of analytical toxicology. (1982) [Pubmed]
 
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