The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Liver


High impact information on Liver

  • These studies indicate that, in man, FFA availability is a major determinant of rates of KB production; insulin does not appear to influence ketogenesis rates by a direct hepatic effect, and glucagon can further augment KB production when FFA concentrations are increased but only in the setting of insulin deficiency [6].
  • Therefore, choline may be an essential nutrient in malnourished cirrhotic patients and its deficiency may be associated with adverse hepatic effects [7].
  • Because the nuclear hormone receptor constitutive androstane receptor (CAR) mediates hepatic effects of this xenobiotic inducer, we hypothesized that CAR could be a regulator of bilirubin clearance [8].
  • Previous studies indicated that insulin does not acutely regulate glucose metabolism by a direct hepatic effect [9].
  • To determine the consequences of their combination, we compared the hepatic effects of moderate ethanol binges in lean and obese ob/ob mice [10].

Chemical compound and disease context of Liver


Biological context of Liver


Anatomical context of Liver


Associations of Liver with chemical compounds


Gene context of Liver


Analytical, diagnostic and therapeutic context of Liver


  1. Insulin delivery rate in response to glucose and arginine infusion in hyperthyroidism. Asano, T., Okumura, M. Diabetologia (1982) [Pubmed]
  2. General anaesthesia for caesarean section in severe pre-eclampsia. Comparison of the renal and hepatic effects of enflurane and halothane. Crowhurst, J.A., Rosen, M. British journal of anaesthesia. (1984) [Pubmed]
  3. Transcription profiling distinguishes dose-dependent effects in the livers of rats treated with clofibrate. Kramer, J.A., Blomme, E.A., Bunch, R.T., Davila, J.C., Jackson, C.J., Jones, P.F., Kolaja, K.L., Curtiss, S.W. Toxicologic pathology. (2003) [Pubmed]
  4. Non-alcoholic steatohepatitis induced by carbamazepine and variegate porphyria. Grieco, A., Alfei, B., Di Rocco, P., Miele, L., Biolcati, G., Griso, D., Vecchio, F.M., Bianco, A., Gasbarrini, G. European journal of gastroenterology & hepatology. (2001) [Pubmed]
  5. Hepatic changes in rats following subchronic administration of FYROL 6, an organophosphorus ester flame retardant. Katz, A.C., Turnier, J.C., Zwicker, G.M., Sprague, G.L. Journal of toxicology and environmental health. (1988) [Pubmed]
  6. Effects of free fatty acid availability, glucagon excess, and insulin deficiency on ketone body production in postabsorptive man. Miles, J.M., Haymond, M.W., Nissen, S.L., Gerich, J.E. J. Clin. Invest. (1983) [Pubmed]
  7. Choline may be an essential nutrient in malnourished patients with cirrhosis. Chawla, R.K., Wolf, D.C., Kutner, M.H., Bonkovsky, H.L. Gastroenterology (1989) [Pubmed]
  8. Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Huang, W., Zhang, J., Chua, S.S., Qatanani, M., Han, Y., Granata, R., Moore, D.D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  9. Insulin exerts metabolic and growth-promoting effects by a direct action on the liver in vivo: clarification of the functional significance of the portal vascular link between the beta cells of the pancreatic islets and the liver. Griffen, S.C., Russell, S.M., Katz, L.S., Nicoll, C.S. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  10. Alcohol increases tumor necrosis factor alpha and decreases nuclear factor-kappab to activate hepatic apoptosis in genetically obese mice. Robin, M.A., Demeilliers, C., Sutton, A., Paradis, V., Maisonneuve, C., Dubois, S., Poirel, O., Lettéron, P., Pessayre, D., Fromenty, B. Hepatology (2005) [Pubmed]
  11. Anesthesia in a patient with undiagnosed salicylate poisoning presenting as intraabdominal sepsis. Chui, P.T. Journal of clinical anesthesia. (1999) [Pubmed]
  12. Hepatic effects of chlorpropamide: inhibition of glucagon-stimulated gluconeogenesis in perfused livers of fasted rats. Blumenthal, S.A., Whitmer, K.R. Diabetes (1979) [Pubmed]
  13. Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma. Donald, S., Verschoyle, R.D., Greaves, P., Colombo, T., Zucchetti, M., Falcioni, C., Zaffaroni, M., D'Incalci, M., Manson, M.M., Jimeno, J., Steward, W.P., Gescher, A.J. Int. J. Cancer (2004) [Pubmed]
  14. Guidelines for the use of antifungal agents in the treatment of invasive Candida and mould infections. Slavin, M.A., Szer, J., Grigg, A.P., Roberts, A.W., Seymour, J.F., Sasadeusz, J., Thursky, K., Chen, S.C., Morrissey, C.O., Heath, C.H., Sorrell, T. Internal medicine journal. (2004) [Pubmed]
  15. Studies of transferrin in serum of workers exposed to organic solvents. Petrén, S., Vesterberg, O. British journal of industrial medicine. (1987) [Pubmed]
  16. The hepatic effects of hypolipidemic drugs (clofibrate, nafenopin, tibric acid, and Wy-14,643) on hepatic peroxisomes and peroxisome-associated enzymes. Moody, D.E., Reddy, J.K. Am. J. Pathol. (1978) [Pubmed]
  17. beta-Agonists and metabolism. Philipson, L.H. J. Allergy Clin. Immunol. (2002) [Pubmed]
  18. Hepatic effects of phthalate esters and related compounds--in vivo and in vitro correlations. Lake, B.G., Gray, T.J., Gangolli, S.D. Environ. Health Perspect. (1986) [Pubmed]
  19. Comparison of hepatic impact of oral and vaginal administration of ethinyl estradiol. Goebelsmann, U., Mashchak, C.A., Mishell, D.R. Am. J. Obstet. Gynecol. (1985) [Pubmed]
  20. Comparison of acute toxic effects of intraperitoneally injected nitromethane and nitroethane in rats. Zitting, A., Nickels, J., Savolainen, H. Toxicol. Lett. (1982) [Pubmed]
  21. Quantitative structure-activity studies on effects of sixteen different steroids on growth and monooxygenases of rat liver. Schulte-Hermann, R., Ochs, H., Bursch, W., Parzefall, W. Cancer Res. (1988) [Pubmed]
  22. Norepinephrine-induced cholestasis in the isolated perfused rat liver is secondary to its hemodynamic effects. Lenzen, R., Funk, A., Kolb-Bachofen, V., Strohmeyer, G. Hepatology (1990) [Pubmed]
  23. Complete protection by high-dose dexamethasone against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the rat. Donald, S., Verschoyle, R.D., Greaves, P., Gant, T.W., Colombo, T., Zaffaroni, M., Frapolli, R., Zucchetti, M., D'Incalci, M., Meco, D., Riccardi, R., Lopez-Lazaro, L., Jimeno, J., Gescher, A.J. Cancer Res. (2003) [Pubmed]
  24. Prostaglandin synthesis inhibitors impair hepatic glucose production in response to glucagon and epinephrine stimulation. Miller, J.D., Ganguli, S., Sperling, M.A. Diabetes (1983) [Pubmed]
  25. The use of biochemical and molecular parameters to estimate dose-response relationships at low levels of exposure. Andersen, M.E., Barton, H.A. Environ. Health Perspect. (1998) [Pubmed]
  26. Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women. Vongpatanasin, W., Tuncel, M., Wang, Z., Arbique, D., Mehrad, B., Jialal, I. J. Am. Coll. Cardiol. (2003) [Pubmed]
  27. Hypoglycemia and resistance to ketoacidosis in a subject without functional insulin receptors. Ogilvy-Stuart, A.L., Soos, M.A., Hands, S.J., Anthony, M.Y., Dunger, D.B., O'Rahilly, S. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  28. Organ-specific effects of tiratricol: a thyroid hormone analog with hepatic, not pituitary, superagonist effects. Sherman, S.I., Ladenson, P.W. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  29. Growth hormone and insulin-like growth factor-I counteracts established steroid catabolism in rats by effects on hepatic amino-N degradation. Grøfte, T., Jensen, D.S., Greisen, J., Tygstrup, N., Vilstrup, H. J. Hepatol. (2001) [Pubmed]
  30. Safety and efficacy of isoniazid chemoprophylaxis administered during liver transplant candidacy for the prevention of posttransplant tuberculosis. Singh, N., Wagener, M.M., Gayowski, T. Transplantation (2002) [Pubmed]
  31. Metabolic and respiratory effects of continuous and discontinuous lipid infusions. Occurrence in excess of resting energy expenditure. Abbott, W.C., Grakauskas, A.M., Bistrian, B.R., Rose, R., Blackburn, G.L. Archives of surgery (Chicago, Ill. : 1960) (1984) [Pubmed]
  32. Chronic toxicity in monkeys with the thiazolidinedione antidiabetic agent troglitazone. Rothwell, C., McGuire, E.J., Altrogge, D.M., Masuda, H., de la Iglesia, F.A. The Journal of toxicological sciences. (2002) [Pubmed]
WikiGenes - Universities